Yilei Mao

3D bioprinted ascites-derived models for gastric cancer patients with peritoneal metastasis

Yuwei Hua, Liwei Du, Hang Sun, Minghao Sun et autres

Gastric cancer with peritoneal metastasis is associated with poor prognosis and marked heterogeneity in treatment response. Reliable patient-derived models for functional drug testing remain limited. This study aimed to develop a malignant ascites-derived three-dimensional bioprinted model and evaluate its utility for drug …

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Exploring clinically anchored therapeutic stratification and tumor-stroma heterogeneity using patient-derived 3D bioprinted primary liver cancer models

Kai Zhang, Liwei Du, Minghao Sun, Yuce Lu et autres

The marked heterogeneity of primary liver cancer (PLC), together with the dynamic influence of the tumor microenvironment (TME), remains a major challenge to precision oncology. As currently available therapies provide limited benefit for many patients and robust preclinical platforms for rapid, patient-specific …

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A 3D-bioprinted osteogenic niche model reveals bone microenvironment-driven malignant phenotypes in prostate cancer

Chengyi Zhong, Mingchang Pang, Hang Sun, Huayu Yang et autres

INTRODUCTION: Prostate cancer (PCa) is one of the most prevalent malignancies in men and frequently progresses to bone metastasis. Understanding the interactions between PCa cells and the bone microenvironment, as well as their impact on therapeutic response, is therefore of critical clinical …

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H2S-mediated protein S-sulfhydration: a novel regulatory module in lipid metabolism

Mingchang Pang, Haoyang Chen, Shuofeng Li, Huayu Yang et autres

H 2 S-mediated protein S-sulfhydration is an emerging post-translational modification that regulates key biological processes via regulating enzyme activities, controlling protein–protein interactions, and modulating signal transduction. Lipid metabolism represents an important target of S-sulfhydration–mediated regulation, which fine-tunes lipid metabolic networks including fatty …

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Multiomics prediction and immunogenic validation of personalized neoantigens in cholangiocarcinoma patients

Baoluhe Zhang, Bao Jin, Xueshuai Wan, Xiao Liu et autres

BACKGROUND: Cholangiocarcinoma (CCA) is an aggressive biliary tract cancer with limited treatment options, underscoring the need for breakthrough precision therapies. Neoantigen-based therapy is a promising novel strategy for cancer treatment. This study investigates the potential of neoantigen peptides in CCA, emphasizing their …

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TOP-145 CBS/HS-Dependent S-Sulfhydration of PREB regulates ApoB-mediated VLDL secretion and hepatic lipid homeostasis

Mingchang Pang, Huayu Yang, Yilei Mao, Yongfa Huang

Abstract 4860: Predicting therapy efficacy and revealing tumor heterogeneity using patient-derived 3D bioprinted ovarian cancer models

Jiangang Zhang, Huiyu Yang, Ying Shan, Z J Zhong et autres

Abstract Ovarian cancer is the most lethal gynecologic malignancy, characterized by tumor heterogeneity and a high recurrence rate. Patient-derived in vitro tumor models offer a promising strategy for individualized drug screening to overcome limitations of systemic therapy. Among existing modeling methodologies, 3D …

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[A case of segmental atrophy of the liver in children].

Y L Qiu, Yilei Mao, C L Lu

回顾性研究1例儿童肝脏巨大的节段性萎缩，采用苏木精-伊红染色、免疫组织化学染色和特殊染色，分析其临床病理表现。结果显示，节段性萎缩位于右半肝S6、S7段，包块边界清晰。镜下见肝细胞萎缩，残留的肝细胞形成岛状结构，无异型性。肝细胞岛周围见小胆管增生及血管生成，伴部分淋巴细胞聚集。可见厚壁血管，部分胆管扩张呈囊性，纤维组织增生伴明显胶原化，靠近中央部间质黏液变性。肝节段性萎缩是一种未被充分认识但需重视的良性假肿瘤性病变，在儿童中极为罕见，可能与局部血管血栓相关。这种病变在影像学和组织学上可以与其他良性或恶性肝肿瘤非常相似，组织学是诊断的金标准。.

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Three-dimensional bioprinting of patient-derived Gastrointestinal stromal tumor: a novel platform for precision oncology and drug response profiling

Liwei Du, Zicheng Zheng, Yanan Wang, Kai Zhang et autres

BACKGROUND: Gastrointestinal stromal tumors (GISTs) exhibit significant heterogeneity, posing substantial challenges for personalized treatment strategies. Patients often display varied responses to different therapeutic agents and dosages. Currently, the absence of robust and physiologically relevant in vitro models for GISTs impedes accurate prediction …

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Rescue of extreme hepatectomy mice by primary hepatocyte-derived 3D bio-printed organ transplantation

Bao Jin, Zhao-Xiong Xie, Yinhan Wang, Lejia Sun et autres

Abstract Three-dimensional (3D) bioprinting is an emerging strategy for constructing tissues and organs in vitro . Here, we achieved long-term expansion of primary mouse hepatocytes using a defined medium and constructed liver tissue using 3D bioprinting. The 3D-printed liver tissue demonstrated several …

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Expert consensus on multidisciplinary collaboration in perioperative immunotherapy for hepatocellular carcinoma (2025 edition)

Zeyang Ding, Chaoyi Yuan, Ying Zhu, Hong Wu et autres

Abstract Immune checkpoint inhibitors (ICIs) have led to substantial advances in immunotherapy for hepatocellular carcinoma (HCC). Moreover, the use of ICI-based combination regimens for perioperative management of HCC has increased. To support clinicians in the rational, effective, and safe use of perioperative …

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Chinese expert consensus on conversion and perioperative therapy of primary liver cancer (2024 edition)

Zheng Wang, Hui‐Chuan Sun, Jian Zhou, Qing Xie et autres

Background: A significant portion of primary liver cancer patients in China are diagnosed at intermediate-to-advanced stages, often making them ineligible for curative surgery. Furthermore, high postoperative recurrence rates, reaching up to 70%, pose a major challenge for long-term survival. The emergence of …

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