Chaoyi Yuan

Targeting SPAK suppresses progression and averts an immune exhaustive microenvironment in hepatocellular carcinoma

Yonglong Pan, Chenglong Zeng, Y L He, Ruizhi Chang et autres

Protein kinases contribute to hepatocellular carcinoma (HCC) development and immune evasion, posing major challenges for HCC management. Here we show STE20/SPS1-related proline/alanine-rich kinase (SPAK) as a candidate immune exhaustion–associated gene identified through a pooled screen of protein kinases. By integrating bioinformatic analyses, …

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Correction: Li et al. Neutrophil Spatiotemporal Regulatory Networks: Dual Roles in Tumor Growth Regulation and Metastasis. Biomedicines 2025, 13, 1473

Pengcheng Li, Feimu Fan, Bixiang Zhang, Chaoyi Yuan et autres

Text Correction [...]

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Expert consensus on multidisciplinary collaboration in perioperative immunotherapy for hepatocellular carcinoma (2025 edition)

Zeyang Ding, Chaoyi Yuan, Ying Zhu, Hong Wu et autres

Abstract Immune checkpoint inhibitors (ICIs) have led to substantial advances in immunotherapy for hepatocellular carcinoma (HCC). Moreover, the use of ICI-based combination regimens for perioperative management of HCC has increased. To support clinicians in the rational, effective, and safe use of perioperative …

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HCC perioperative immunotherapy: Insights from Expert consensus on multidisciplinary collaboration in perioperative immunotherapy for hepatocellular carcinoma (2025 edition)

Chaoyi Yuan, Zeyang Ding, Xiaoping Chen, Lunxiu Qin et autres

1. Introduction Despite substantial advances in systemic immunotherapy for advanced hepatocellular carcinoma (HCC), clinical guidance on its use in the perioperative setting remains limited. The perioperative period, which encompasses the neoadjuvant, intraoperative, and adjuvant phases, offers a unique window to improve long-term …

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Clinical manifestation and pathological changes of serous papillary adenofibroma: A case series

Xiaojing Zhao, Chaoyi Yuan, Xinrun Wang, Yang Liu et autres

Serous papillary adenofibroma (SPAF) is a rare benign tumor in gynecological practice. Most patients have no symptoms and occasionally present with pelvic masses during physical examinations. SPAF consists of both fibrous and epithelial parts, which makes it easy to misdiagnose malignancies on …

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Neutrophil Spatiotemporal Regulatory Networks: Dual Roles in Tumor Growth Regulation and Metastasis

Pengcheng Li, Feimu Fan, Bixiang Zhang, Chaoyi Yuan et autres

Neutrophils, accounting for 50–70% of circulating leukocytes, exhibit remarkable plasticity in tumor biology. Depending on tumor type and microenvironmental cues, they can exert either anti-tumor or pro-tumor effects. During tumor initiation, neutrophils exposed to chronic inflammation secrete cytokines and oncogenic microRNAs that …

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Cancer stem cells and niches: challenges in immunotherapy resistance

Yonglong Pan, Chaoyi Yuan, Chenglong Zeng, Chaoyang Sun et autres

Cancer stem cells (CSCs) are central to tumor progression, metastasis, immune evasion, and therapeutic resistance. Characterized by remarkable self-renewal and adaptability, CSCs can transition dynamically between stem-like and differentiated states in response to external stimuli, a process termed "CSC plasticity." This adaptability …

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The effect of coagulation traits on the risk of retinal vein occlusion: a mendelian randomization study

Chaoyi Yuan, Chao He, Ling Zuo, Baoxing Liu et autres

Retinal vein occlusion (RVO) is the leading cause of vision loss due to an obstruction in the retinal venous system. While RVO is often linked to thrombotic tendencies and coagulation abnormalities, the exact role of coagulation traits in its development is not …

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Secretogranin III: a promising therapeutic target for intraocular neovascular lesions

Chaoyi Yuan, Ling Zuo, Baoxing Liu, Hui Qi

PURPOSE: The purpose of this study is to investigate the role of Secretogranin III (Scg3) in the pathogenesis of intraocular neovascular diseases and assess its potential as a therapeutic target for novel treatment strategies. METHODS: A literature review was conducted to examine …

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CKAP4 in hepatocellular carcinoma: competitive RETREG1/FAM134B binding, reticulophagy regulation, and cancer progression

Jie Mo, Su Chen, Pengcheng Li, Zhenhua Yang et autres

RETREG1/FAM134B is known for its role as a reticulophagy receptor. Our previous study established that RETREG1 is upregulated in hepatocellular carcinoma (HCC) and contributes to disease progression by activating the AKT signaling pathway. However, the specific mechanisms underlying the elevated expression of …

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Regulator of nonsense transcripts 3B is a prognostic biomarker and associated with immune cell infiltration in lung squamous cell and hepatocellular carcinoma

Pengcheng Li, Mi Zhou, Xiaoli Gan, Chaoyi Yuan et autres

PURPOSE: The characteristic of RENT3B in cancer remains ambiguous. We aimed to study the relationship between RENT3B and immune infiltration in liver hepatocellular carcinoma (LIHC) and lung squamous cell carcinoma (LUSC). PATIENTS AND METHODS: We investigated the expression levels of RENT3B using …

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The effect of coagulation traits on the risk of retinal vein occlusion: a mendelian randomization study

Chaoyi Yuan, Chao He, Ling Zuo, Baoxing Liu et autres

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