Joshua C. Doloff

Engineering Lipid Nanoparticles through Integrated Compositional and Ligand Targeting Enhances β Cell-Directed RNA Delivery

Di Yu, Yining Zhu, Arturo Roca-Rivada, Zheng Guo et autres

Beyond their deployment as COVID-19 vaccines, lipid nanoparticles (LNPs) have emerged as versatile vehicles for therapeutic nucleic acid delivery. However, achieving efficient and cell-targeted transfection in extrahepatic tissues, particularly pancreatic β cells, remains a major challenge. Here, we develop a dual-targeting LNP …

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Formulation and assessment of long-acting pharmaceutical co-formulated crystals

Jamie L. Hernandez, Neeti R. Prasad, Jonathan Daniel, Victor M. Quiroz et autres

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Unnecessary Roughness: Why Surface Topography and Host Response Interpretation Matter

Joshua C. Doloff, Mark Warren Clemens, Omid Veiseh

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Data from: Biodegradable acoustic targeting for ultrasound-supported gene therapy (BATUS) in glioblastoma

Gülşah Erel‐Akbaba, Jinyoung Park, Achal Duhoon, Cường Quốc Nguyễn et autres

Glioblastoma (GBM) remains one of the most challenging brain malignancies due to the restrictive nature of the blood–brain barrier (BBB), which severely limits effective drug and gene delivery. To overcome this, we introduce Biodegradable Acoustic Targeting for Ultrasound-Supported Gene Therapy (BATUS), a …

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Biodegradable Acoustic Targeting for Ultrasound‐Supported Gene Therapy (BATUS) in Glioblastoma

Gulsah Erel-Akbaba, Jinyoung Park, Achal Duhoon, Cường Quốc Nguyễn et autres

Glioblastoma (GBM) remains one of the most challenging brain malignancies due to the restrictive nature of the blood-brain barrier (BBB), which severely limits effective drug and gene delivery. To overcome this, we introduce Biodegradable Acoustic Targeting for Ultrasound-Supported Gene Therapy (BATUS), a …

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Intraocular delivery of crystalline sorafenib provides sustained, potent inhibition of wet age-related macular degeneration

Haining Lu, Amanda I. Rakoski, Kaoru Ri, Lingli Zhou et autres

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From Bench to Bedside: Clinical Implications of a 4-Micron Surface-Modulated Immune Response in the Era of Breast Tissue Preservation

M Bradley Calobrace, Brian M. Kinney, Joshua C. Doloff, Omid Veiseh et autres

Breast implant surface topography plays a critical role in modulating host immune responses and long-term clinical outcomes. Although traditional classifications dichotomize implant surfaces as smooth or textured, emerging evidence demonstrates that specific architectural parameters differentially regulate macrophage polarization, T cell recruitment, and …

Synovial metaplasia in capsules of macrotextured and smooth breast implants: A comparative study

Olga Ivanenko, Lara Sforza, Ashish Lobo, Vance V. Soares et autres

BACKGROUND: Synovial metaplasia in periprosthetic breast implant capsules is a clinically relevant but understudied phenomenon, especially at the cellular level. OBJECTIVES: The purpose of this study was to assess the prevalence, severity, histological features, and marker expression characteristics of synovial metaplasia in …

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Immune-competent new approach methodologies for a hybrid future

Vance Soares, Victor M. Quiroz, Martin Trapečar, Deok-Ho Kim et autres

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Immune roles of canonically non-immune cells in biomaterials response

Jessica L. Stelzel, Ian McKnight, Autumn H. Greco, Jamie L. Hernandez et autres

Despite advances in immunology, including recognition of the immune-related functions of cells beyond leukocytes, a disconnect remains between immunology and biomaterials development. Such advances have not been consistently integrated into biomaterials research, and this gap is even more pronounced for these canonically …

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Fibroblast signaling influences macrophage-dependent, biomaterial-induced tissue remodeling

Jessica L. Stelzel, Stuart J. Bauer, B. Ni, Zhi‐Cheng Yao et autres

Abstract The ability to induce tissue regeneration on demand using biomaterials remains a major goal in biomedical research, yet significant challenges persist. Among the most advanced biomaterial models, the nanofiber-hydrogel composite has demonstrated a striking ability to induce soft adipose tissue remodeling …

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Engineering age-adaptive mRNA lipid nanoparticle cancer vaccines via reprogramming systemic gene expression

Yining Zhu, Christine Y. Wei, Jingyao Ma, Di Yu et autres

Lipid nanoparticle (LNP)-based mRNA vaccines have transformed cancer immunotherapy, yet their efficacy in older individuals, who represent the majority of cancer patients, remains poorly understood. Here, we uncover a critical and previously underappreciated barrier to mRNA LNP cancer vaccine performance in aged …

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