2026
conference-abstract
OpenAlex
Reema Baskar, Vairavan Lakshmanan, Dane Bagaoisan, Wilfred Wong et autres
Abstract The tumor microenvironment (TME) orchestrates immune evasion and therapeutic resistance in colorectal cancer (CRC), particularly in microsatellite stable (MSS) tumors that exhibit poor responses to immunotherapy. While the cellular component of the TME has been extensively characterized, the contribution of the …
sg, us
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Accès ouvert
2025
article
OpenAlex
Hadeesha Piyadasa, Benjamin Oberlton, Mikaela Ribi, Ke Xuan Leow et autres
us, it
(code pays fourni par la source)
2025
conference-abstract
OpenAlex
Reema Baskar, Vairavan Lakshmanan, Audrey W. Q. Lee, Wilfred Hing Sang Wong et autres
Abstract Colorectal cancer (CRC) progression is driven by a complex interplay of immunosuppressive and inflammatory mechanisms involving various cell types, functional states, and extracellular milieu. To unravel this intricate relationship, we took a systems biology approach using high resolution spatial distributions of …
sg, us
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
Hadeesha Piyadasa, Benjamin Oberlton, Mikaela Ribi, Jolene S. Ranek et autres
Gliomas are among the most lethal cancers, with limited treatment options. To uncover hallmarks of therapeutic escape and tumor microenvironment (TME) evolution, we applied spatial proteomics, transcriptomics, and glycomics to 670 lesions from 310 adult and pediatric patients. Single-cell analysis shows high …
us, it
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Accès ouvert
2024
erratum
OpenAlex
Sanjay R. Jain, Liming Pei, Jeffrey M. Spraggins, Michael R. Angelo et autres
us, nl, gb
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Accès ouvert
2023
article
OpenAlex
Sanjay R. Jain, Liming Pei, Jeffrey M. Spraggins, Michael R. Angelo et autres
The Human BioMolecular Atlas Program (HuBMAP) aims to create a multi-scale spatial atlas of the healthy human body at single-cell resolution by applying advanced technologies and disseminating resources to the community. As the HuBMAP moves past its first phase, creating ontologies, protocols …
us, nl, gb
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Accès ouvert
2022
article
OpenAlex
A. R. Moore, Nora Vivanco Gonzalez, Katherine A. Plummer, Olivia R. Mitchel et autres
The immune system and placenta have a dynamic relationship across gestation to accommodate fetal growth and development. High-resolution characterization of this maternal-fetal interface is necessary to better understand the immunology of pregnancy and its complications. We developed a single-cell framework to simultaneously …
us, in
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Accès ouvert
2021
preprint
OpenAlex
Marc MB Bosse, Ferda Filiz, Noah F. Greenwald, Christine Camacho et autres
We aim to provide high resolution, high dimensional images of human placenta in early pregnancy by using our multiplexed ion beam imaging methodology for building an atlas of human organs.
2004
conference-abstract
OpenAlex
Ricardo Orlando Castillo, Charles A. Pratt, Ferda Filiz
Introduction: Advances in surgical technique, medical management, immunosuppression and surveillance have resulted in improved outcomes for patients undergoing intestinal transplantation (IT). Although it is known that intestinal absorptive function is not normal after transplant, few studies have been done investigating absorptive function …
us
(code pays fourni par la source)
2004
conference-abstract
OpenAlex
Ricardo Orlando Castillo, Charles A. Pratt, Ferda Filiz
us
(code pays fourni par la source)
2002
article
OpenAlex
Lu Shan, Øyvind Molberg, Isabelle Parrot, Felix Hausch et autres
Celiac Sprue, a widely prevalent autoimmune disease of the small intestine, is induced in genetically susceptible individuals by exposure to dietary gluten. A 33-mer peptide was identified that has several characteristics suggesting it is the primary initiator of the inflammatory response to …
us, no
(code pays fourni par la source)
2002
book-chapter
OpenAlex
Geoffrey T. Manley, Miki Fujimura, Tonghui Ma, Nobuo Noshita et autres
Introduction Abnormalities in brain water balance, such as edema and increased intracranial pressure, play an important role in the pathophysiology of acute head trauma, stroke and a variety of neurological disorders. However, little is known about the molecular mechanisms responsible for these …
us
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