Jong Won Han

Genetic diversity and cultivar identification in Rehmannia glutinosa using morphological traits and genome-wide SNP/InDel variation

Sumin Jeong, Yun Ji Park, Ye Hwan Kang, Yeseul Kim et autres

Rehmannia glutinosa is increasingly recognized as a multifunctional bioresource in health-related industries, including functional foods and cosmetics, driven by its traditional use and rising demand for preventive healthcare. To support its sustainable utilization, numerous cultivars have been developed to improve root yield, …

kr (code pays fourni par la source)

Pathological tau propagation from the brain to the colon via the vagal efferent pathway in Alzheimer’s disease

Hyunjung Choi, Seok Beom Hong, Hui-Wen Liu, Hyeonggyu Song et autres

BACKGROUND: Alzheimer's disease (AD) is a neurodegenerative disorder marked by the accumulation of amyloid-β (Aβ) plaques and tau neurofibrillary tangles, leading to cognitive decline. Recent research has highlighted the involvement of the gut-brain axis (GBA) in AD progression, suggesting that the disease …

kr, Éthiopie, jp (code pays fourni par la source)

Monitoring the Dynamics of Alzheimer's Disease Biomarkers and the APOE–Tau Axis via Human Cerebral Organoids with Immuno‐SERS (Adv. Sci. 35/2025)

Yongjae Jo, Young Jun Kim, Rian Kang, Seho Lee et autres

SERS Unlocks Tau Secretion Profiles in Brain Organoids Label-free and non-invasive monitoring of the Alzheimer's disease biomarker from human cerebral organoids has not yet been accomplished. In article number 2505660, Inki Kim, Luke P. Lee, Jong-Chan Park, and co-workers report a SERS-based …

Comparison of methods for rapid non-destructive and destructive measurement of dry matter and soluble solids content in ‘Zesy002’ kiwifruit

R. Valkenburg, S. Walbran, D. Galbraith, Jong Won Han

Comparison of methods for rapid non-destructive and destructive measurement of dry matter and soluble solids content in ‘Zesy002’ kiwifruit

R. Valkenburg, S. Walbran, D. Galbraith, Jong Won Han

Monitoring the Dynamics of Alzheimer's Disease Biomarkers and the APOE –Tau Axis via Human Cerebral Organoids with Immuno‐SERS

Yongjae Jo, Young Jun Kim, Rian Kang, Seho Lee et autres

Noninvasive monitoring of Alzheimer's disease (AD) biomarkers is essential for early diagnosis and treatment efficacy. However, noninvasive monitoring of tau protein secretion, a key biomarker of AD, across developmental stages, age-related variations, and the interaction between apolipoprotein E (APOE) and the tau …

kr, us (code pays fourni par la source)

Phytochemical and pharmacological profiles of various Salvia miltiorrhiza Bunge cultivars grown in Korea

Samuel Park, Yejin Kim, Jun‐Ho Kim, Hui‐Jeon Jeon et autres

The present study, we investigated the phenolic acid and tanshinone compositions of different cultivars of Salvia miltiorrhiza Bunge grown in Korea and the effects of their ethanolic extracts on inflammation in the cocultures of adipocytes and macrophages. Major phytochemicals in S. miltiorrhiza …

kr (code pays fourni par la source)

Skin benefits of green tea–derived exosomes

Ji‐Seon Hyun, Pomjoo Lee, Ju Mi Hyun, Yeon Jeong Jo et autres

kr (code pays fourni par la source)

Long‐term exposure to excessive norepinephrine in the brain induces tau aggregation, neuronal death, and cognitive deficits in early tau transgenic mice

June‐Hyun Jeong, Dong Kyu Kim, Sunwoo Chung, Jong Won Han et autres

Abstract Alzheimer's disease (AD) is marked by the presence of intraneuronal neurofibrillary tangles (NFTs), which are primarily composed of hyperphosphorylated tau protein. The locus coeruleus (LC), the brain's main source of norepinephrine (NE), is one of the earliest regions to develop NFTs …

kr (code pays fourni par la source)

Complete chloroplast genomes of three Polygala species and indel marker development for identification of authentic polygalae radix (Polygala tenuifolia)

Su‐Min Jeong, Jong Won Han, Yeseul Kim, Kyung‐Ho Ma et autres

kr (code pays fourni par la source)

Differentiating visceral sensory ganglion organoids from induced pluripotent stem cells

Kyusik Ahn, Hwee-Seon Park, Sieun Choi, Ho-Jeong Lee et autres

kr, jp, pr (code pays fourni par la source)

Blockade of STING activation alleviates microglial dysfunction and a broad spectrum of Alzheimer’s disease pathologies

Sunwoo Chung, June‐Hyun Jeong, Jong‐Chan Park, Jong Won Han et autres

Abstract Abnormal glial activation promotes neurodegeneration in Alzheimer’s disease (AD), the most common cause of dementia. Stimulation of the cGAS-STING pathway induces microglial dysfunction and sterile inflammation, which exacerbates AD. We showed that inhibiting STING activation can control microglia and ameliorate a …

kr, pr (code pays fourni par la source)