Chongbo Zhao

Steaming reduces Polygonum multiflorum hepatotoxicity by modulating gut microbiota-bile acid-FXR/NF-κB signaling in the gut-liver axis

Arthur Dong, Ya-Ya Bai, Yang Xiao, Rui-Rui Qiao et autres

cn (code pays fourni par la source)

In‐Depth Profiling Highlights the Effect of Efgartigimod on Peripheral Innate and Adaptive Immune Cells in Myasthenia Gravis

Lei Jin, Dong Liu, Ying Wang, Dingxian He et autres

ABSTRACT Background Myasthenia gravis (MG) is an autoimmune disorder characterized by antibody‐mediated complement activation. Efgartigimod, a neonatal Fc receptor (FcRn) antagonist, is approved for treating generalized MG (gMG). However, its modulatory effects on upstream innate and adaptive immune cells remain largely unexplored. …

cn (code pays fourni par la source)

Rituximab for refractory ocular symptoms in myasthenia gravis with thyroid eye disease: a case report with quantitative MRI assessment

Dingxian He, Xiangwen Li, Baitong Wang, Yaqi Wang et autres

Aims: To report a case with concurrent myasthenia gravis (MG) and thyroid eye disease (TED) showing response to rituximab (RTX) through both clinical evaluation and quantitative MRI assessment. Methods: A 31-year-old female patient with refractory ocular symptoms from concurrent MG and TED …

cn, us (code pays fourni par la source)

Corrigendum to “Pharmacodynamic effects and mechanism of Pueraria lobata-Schisandra chinensis combination in the treatment of alcoholic liver disease” [Fitoterapia 187 (2025) 106873]

Shihao Zhang, Ding Liu, Dongyan Guo, Chongbo Zhao et autres

cn (code pays fourni par la source)

The role of gut microbiota in diarrhea and its alleviation through microbiota-targeted interventions

Rui Tian, Yaya Bai, Ni Chen, Ruirui Qiao et autres

Diarrhea is a common gastrointestinal disease and closely related to the balance of the gut microbiota (GM). In turn, dysregulation of the GM can affect the onset and progression of diarrhea through regulating the metabolism, intestinal immune function, intestinal barrier function and …

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Corydalis rhizoma attenuates primary dysmenorrhea in rats by inhibiting the FAK/PI3K-AKT/NF-κB signaling pathway

Jie Zhang, Ming Dang, Yanan Wu, Arthur Dong et autres

cn (code pays fourni par la source)

A Review on Antifungal Activity of Plant Essential Oils

Kai Li, Jianbo Guo, Ruiping Liang, Xuan Wang et autres

Fungal infections pose a significant threat to human health, crop production, and food safety. Concurrently, traditional antifungal drugs face challenges such as increasing drug resistance and adverse side effects, creating an urgent need for safer and more efficient therapeutic alternatives. Although significant …

cn (code pays fourni par la source)

Arisaema cum Bile Mitigate Febrile Seizure in Rats via Inhibition of Neuroinflammation, Regulation of FXR and GABA Signaling Pathway

Wu Xu, Lian Zhong, Jing Wang, Qiao Zhang et autres

Background: Arisaema cum bile (known as DanNan Xing in Chinese, DNX) is a traditional herbal medicine commonly used to treat febrile seizure (FS), but the underlying mechanism remains unclear. Objective: To evaluate the therapeutic effect of DNX on hot water bath-induced FS …

cn, cz (code pays fourni par la source)

Platycodon grandiflorum Attenuates Non‐Alcoholic Fatty Liver Disease in Rats Through Regulating Inflammatory Response via PPARγ and TLR4/NF‐κB Signaling Pathway

Ming Dang, Jie Zhang, Mingui Fu, Kai Li et autres

Non-alcoholic fatty liver disease (NAFLD) has been considered a main health concern worldwide, and Platycodon grandiflorum (PG) has been traditionally employed in ethnopharmacology for managing hepatic metabolic disorders. This study aimed to elucidate the potential effect of PG on NAFLD in rats, …

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The Phase 3 PREVAIL Study Assessing the Efficacy and Safety of Subcutaneous Gefurulimab in Adults with Generalized Myasthenia Gravis: Trial in Progress (P7-11.021)

James Anthony Howard, Kelly Graham Gwathmey, Chongbo Zhao, Sanjay N. Rakhade et autres

Provide an overview of PREVAIL, which is evaluating the efficacy and safety of gefurulimab in adults with anti-acetylcholine receptor antibody-positive (AChR-Ab+) generalized myasthenia gravis (gMG).

us, cn, br, ch (code pays fourni par la source)

Revealing the optimal traditional processing methods and its protective effects against febrile seizures of Arisaema cum bile

Mengmeng Zhang, Xu Wu, Jing Wang, Ting Zou et autres

Arisaema cum bile (known as Dan Nanxing in Chinese, DNX) is a herbal medicine used for treating febrile seizure (FS), which commonly prepared by using Arisaematis Rhizoma and animal bile. This study was designed to explore the optimal processing time of DNX …

cn (code pays fourni par la source)

Long‐term and low‐dose rituximab treatment for chronic inflammatory demyelinating polyneuropathy

Yongsheng Zheng, Chong Sun, Yanyin Zhao, Quanhua Meng et autres

OBJECTIVE: To evaluate the efficacy and safety of a low-dose, long-term rituximab regimen in the treatment of idiopathic CIDP. METHODS: This study included 15 CIDP patients treated with rituximab. Patients were administered 600 mg of rituximab intravenously every 6 months. Baseline evaluation …

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