Jing Wang

Cryptosporidium parvum protease INS6 plays an important role in parasite proliferation and pathogenicity

Wei He, Zuwei Yang, Jing Wang, Fuxian Yang et autres

BACKGROUND: Cryptosporidium parvum is a common protozoan pathogen responsible for moderate to severe diarrhea in humans and animals. Parasite invasion and egress cause damage to intestinal epithelial cells, which is mediated by a variety of secretory proteins from several unique organelles, such …

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Arisaema cum Bile Mitigate Febrile Seizure in Rats via Inhibition of Neuroinflammation, Regulation of FXR and GABA Signaling Pathway

Wu Xu, Lian Zhong, Jing Wang, Qiao Zhang et autres

Background: Arisaema cum bile (known as DanNan Xing in Chinese, DNX) is a traditional herbal medicine commonly used to treat febrile seizure (FS), but the underlying mechanism remains unclear. Objective: To evaluate the therapeutic effect of DNX on hot water bath-induced FS …

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Platycodon grandiflorum Attenuates Non‐Alcoholic Fatty Liver Disease in Rats Through Regulating Inflammatory Response via PPARγ and TLR4/NF‐κB Signaling Pathway

Ming Dang, Jie Zhang, Mingui Fu, Kai Li et autres

Non-alcoholic fatty liver disease (NAFLD) has been considered a main health concern worldwide, and Platycodon grandiflorum (PG) has been traditionally employed in ethnopharmacology for managing hepatic metabolic disorders. This study aimed to elucidate the potential effect of PG on NAFLD in rats, …

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Circulating inflammatory cytokines and colorectal cancer: New insights from Mendelian randomization

Qinglu Fan, Jing Wang, Miao Tian, Abdulla Sawut et autres

Colorectal cancer (CRC) is one of the most common cancers worldwide and inflammation is believed to play an important role in CRC. In this study, we comprehensively analyzed the causal association between 91 circulating inflammatory cytokines and the risk of CRC using …

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Retention of indoxyl sulfate in different genotypes of ABCC2 may explain variation in tacrolimus pharmacokinetics

Jing Wang, Siqi Huang, Yuanchen Li, Min Wang et autres

Background Microbiota-derived toxins indoxyl sulfate and hippuric acid were previously reported to be associated with altered pharmacokinetics of the immunosuppressant tacrolimus in liver transplant recipients, and ABC transporter proteins are likely to be involved in the transport of such substances, but the …

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Development and application of a physiologically-based pharmacokinetic model for ractopamine in goats

Jing Ai, Yunfeng Gao, Fan Yang, Zhen Zhou Zhao et autres

Physiologically Based Pharmacokinetic (PBPK) models can provide forecasts of the drug residues within the organism. Ractopamine (RAC) is a typical β-agonist. In this study, we developed a PBPK model for RAC in goats. The goal was to predict the distribution of the …

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Mid‐dosing interval concentration is important for polymyxin B exposure and acute kidney injury in critically ill patients

Jing Wang, Yuanchen Li, Siqi Huang, Min Wang et autres

Abstract This study aimed to evaluate the association between polymyxin B (PMB) exposure and acute kidney injury (AKI) and analyze the risk factors for PMB‐induced AKI in critically ill patients. Plasma concentrations of PMB were determined using an ultraperformance liquid chromatography–tandem mass …

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Prediction of 30-Day Mortality Using the Quick Pitt Bacteremia Score in Hospitalized Patients with Klebsiella pneumoniae Infection [Letter]

Huiyan Yang, Shengqi Huang, Jing Wang

Prediction of 30-Day Mortality Using the Quick Pitt Bacteremia Score in Hospitalized Patients with Klebsiella pneumoniae Infection by Su et al 1 in the reputable journal "Infection and Drug Resistance". Firstly, I would like to congratulate the authors and acknowledge their successful …

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Population Pharmacokinetics of Voriconazole and Dose Optimization in Chinese Elderly Patients

Jing Wang, Yue Mao Shen, Zejun Wu, Huaijun Zhu et autres

Objectives: This study aimed to establish a population pharmacokinetic model for elderly individuals receiving intravenous voriconazole, and to assess and optimize the dosing regimens using a simulating approach. Methods: A population pharmacokinetic analysis was conducted using the NONMEN software based on 438 …

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External Evaluation of Population Pharmacokinetic Models to Inform Precision Dosing of Meropenem in Critically Ill Patients

Nan Yang, Jing Wang, Yueliang Xie, Junjie Ding et autres

Routine clinical meropenem therapeutic drug monitoring data can be applied to model-informed precision dosing. The current study aimed to evaluate the adequacy and predictive capabilities of the published models with routine meropenem data and identify the dosing adaptations using a priori and …

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Bailing Capsule combined with α-ketoacid tablets for stage 3 chronic kidney disease

Xiuhong Hu, Jing Wang, Hongjuan Yang, Suhua Ji et autres

BACKGROUND: Chronic kidney disease (CKD) is a progressive and irreversible loss of kidney function. After stage 3, there will be increased risks of hypertension, heart failure, bone disease, anemia, gastrointestinal symptoms, and progression to end-stage kidney failure without proper intervention and treatment. …

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Determination of gamithromycin residues in eggs, milk and edible tissue of food-producing animals by solid phase extraction combined with ultrahigh-performance liquid chromatography-tandem mass spectrometry

Yonghuan Yan, Haichao Zhang, Lianfeng Ai, Weijun Kang et autres

A high throughput method was developed and validated for the quantitation of gamithromycin residues in eggs, milk and animal tissues (leg muscle, kidney, liver and fat) of different species and genera. This was undertaken using ultrahigh-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS). The …