Magdalena Śmiech

Correction to: New CEACAM-targeting 2A3 single-domain antibody-based chimeric antigen receptor T-cells produce anticancer effects in vitro and in vivo

Iga Jancewicz, Magdalena Śmiech, Magdalena Winiarska, Radosław Zagożdżon et autres

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DMRTA2 supports glioma stem-cell mediated neovascularization in glioblastoma

Marta Maleszewska, Kamil Wojnicki, Jakub Mieczkowski, Sylwia Król et autres

Glioblastoma (GBM) is the most common and lethal brain tumor in adults. Due to its fast proliferation, diffusive growth and therapy resistance survival times are less than two years for patients with IDH-wildtype GBM. GBM is noted for the considerable cellular heterogeneity, …

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New CEACAM-targeting 2A3 single-domain antibody-based chimeric antigen receptor T-cells produce anticancer effects in vitro and in vivo

Iga Jancewicz, Magdalena Śmiech, Magdalena Winiarska, Radosław Zagożdżon et autres

Recently, a breakthrough immunotherapeutic strategy of chimeric antigen receptor (CAR) T-cells has been introduced to hematooncology. However, to apply this novel treatment in solid cancers, one must identify suitable molecular targets in the tumors of choice. CEACAM family proteins are involved in …

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Oncogenic Mutation BRAF V600E Changes Phenotypic Behavior of THLE-2 Liver Cells through Alteration of Gene Expression

Magdalena Śmiech, Paweł Leszczyński, Christopher P. Wardell, Piotr Poznański et autres

The accumulation of mutations in cancer driver genes, such as tumor suppressors or proto-oncogenes, affects cellular homeostasis. Disturbances in the mechanism controlling proliferation cause significant augmentation of cell growth and division due to the loss of sensitivity to the regulatory signals. Nowadays, …

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Molecular Characterisation of Uterine Endometrial Proteins during Early Stages of Pregnancy in Pigs by MALDI TOF/TOF

Dorota Pierzchała, Kamila P. Liput, A. Korwin‐Kossakowska, Magdalena Ogłuszka et autres

The molecular mechanism underlying embryonic implantation is vital to understand the correct communications between endometrium and developing conceptus during early stages of pregnancy. This study’s objective was to determine molecular changes in the uterine endometrial proteome during the preimplantation and peri-implantation between …

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NRF2 DLG Domain Mutations Identified in Japanese Liver Cancer Patients Affect the Transcriptional Activity in HCC Cell Lines

Effi Haque, Magdalena Śmiech, Kamila Łuczyńska, Marie France Bouchard et autres

Geographically, East Asia had the highest liver cancer burden in 2017. Besides this, liver cancer-related deaths were high in Japan, accounting for 3.90% of total deaths. The development of liver cancer is influenced by several factors, and genetic alteration is one of …

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Xanthohumol for Human Malignancies: Chemistry, Pharmacokinetics and Molecular Targets

Vancha Harish, Effi Haque, Magdalena Śmiech, Hiroaki Taniguchi et autres

L. (Hop plant). XH is an important ingredient in beer and is considered a significant bioactive agent due to its diverse medicinal applications, which include anti-inflammatory, antimicrobial, antioxidant, immunomodulatory, antiviral, antifungal, antigenotoxic, antiangiogenic, and antimalarial effects as well as strong anticancer activity …

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Emerging Roles of PRDM Factors in Stem Cells and Neuronal System: Cofactor Dependent Regulation of PRDM3/16 and FOG1/2 (Novel PRDM Factors)

Paweł Leszczyński, Magdalena Śmiech, Emil D. Parvanov, Chisato Watanabe et autres

PRDI-BF1 (positive regulatory domain I-binding factor 1) and RIZ1 (retinoblastoma protein-interacting zinc finger gene 1) (PR) homologous domain containing (PRDM) transcription factors are expressed in neuronal and stem cell systems, and they exert multiple functions in a spatiotemporal manner. Therefore, it is …

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Emerging BRAF Mutations in Cancer Progression and Their Possible Effects on Transcriptional Networks

Magdalena Śmiech, Paweł Leszczyński, Hidetoshi Kono, Christopher P. Wardell et autres

Gene mutations can induce cellular alteration and malignant transformation. Development of many types of cancer is associated with mutations in the B-raf proto-oncogene (BRAF) gene. The encoded protein is a component of the mitogen-activated protein kinases/extracellular signal-regulated kinases (MAPK/ERK) signaling pathway, transmitting …

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Deletion of the Prdm3 Gene Causes a Neuronal Differentiation Deficiency in P19 Cells

Paweł Leszczyński, Magdalena Śmiech, Aamir Salam Teeli, Effi Haque et autres

PRDM (PRDI-BF1 (positive regulatory domain I-binding factor 1) and RIZ1 (retinoblastoma protein-interacting zinc finger gene 1) homologous domain-containing) transcription factors are a group of proteins that have a significant impact on organ development. In our study, we assessed the role of Prdm3 …

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Molecular Mechanisms Underlying Hepatocellular Carcinoma Induction by Aberrant NRF2 Activation-Mediated Transcription Networks: Interaction of NRF2-KEAP1 Controls the Fate of Hepatocarcinogenesis

Effi Haque, Md. Rezaul Karim, Aamir Salam Teeli, Magdalena Śmiech et autres

NF-E2-related factor 2 (NRF2) is a basic leucine zipper transcription factor, a master regulator of redox homeostasis regulating a variety of genes for antioxidant and detoxification enzymes. NRF2 was, therefore, initially thought to protect the liver from oxidative stress. Recent studies, however, …

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Sequential changes in histone modifications shape transcriptional responses underlying microglia polarization by glioma

Marta Maleszewska, Aleksandra Steranka, Magdalena Śmiech, Beata Kaza et autres

Microglia, resident myeloid cells of the central nervous system (CNS), act as immune sentinels that contribute to maintenance of physiological homeostasis and respond to any perturbation in CNS. Microglia could be polarized by various stimuli to perform dedicated functions and instigate inflammatory …

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