Joseph Westaby

A case of rapid and extensive cardiac myocyte microcalcification in a patient admitted to intensive care following out-of-hospital cardiac arrest

Gayath Bimal Jayarathna, Joseph Westaby, Mary N. Sheppard

Background: Early myocardial calcification is an uncommon histopathological finding and is usually associated with chronic myocardial injury. Rapid intramyocyte microcalcification following global ischemia is rarely described. Case presentation: A 42-year-old previously healthy male suffered an out-of-hospital cardiac arrest while cycling. Following prolonged …

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Atrial fibrillation and sudden cardiac death, a nested case-control study looking at cardiac pathology

Isaac Chung, Mary N. Sheppard, Joseph Westaby

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Quantitative Histological Insights Into Sudden Arrhythmic Death Syndrome: Findings From a Forensic Autopsy Cohort

Pernille Heimdal Holm, Thomas Hartvig Lindkær Jensen, Joseph Westaby, Mary N. Sheppard et autres

Sudden arrhythmic death syndrome (SADS) is a major cause of sudden cardiac death in young individuals, characterized by structurally normal hearts and negative toxicology. Although guidelines recommend family screening, phenotyping remains challenging. This study applied quantitative histology and deep-learning-based cell segmentation to …

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Antemortem Underdiagnosis of Cardiac Amyloidosis in Sudden Cardiac Death Victims

Giuseppe Ciliberti, Joseph Westaby, Gherardo Finocchiaro, Michael Papadakis et autres

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Sudden perioperative death post aortic valve replacement with autopsy showing hypertrophic cardiomyopathy in elderly female

Zubair Abdul Razak, Joseph Westaby, Mary N. Sheppard

INTRODUCTION: Perioperative death is a catastrophic event for the family and the surgical team. It is in the interest of both that an autopsy is carried out to explain the death. We report a sudden perioperative death post aortic valve replacement in …

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Aortic regurgitation as a cause of sudden cardiac death with aortic and left ventricular remodelling - the role of the bicuspid valve

Lauren Moran, Joseph Westaby, Mary N. Sheppard

BACKGROUND AND OBJECTIVE: Aortic regurgitation (AR) results in blood flow from the aorta back into the left ventricle, which leads to left ventricular hypertrophy and dilation which, in a clinical setting, leads to heart failure and death. However, it is not a …

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Cardiovascular disease reported as modes of death in the Office for National Statistics mortality data: a retrospective observational study

Joseph Westaby, Anne-Marie Gabrawi, Mary N. Sheppard

Objective: A cause of death is a specific disease or injury which directly led to the death whereas a mode of death which is a mechanism such as respiratory failure, cardiac arrest or cardiac failure but does not provide the cause of …

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Sudden Cardiac Death in Childhood: Peaks in Teenagers

Joseph Westaby, Mary N. Sheppard

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Sudden cardiac death during anesthesia in non-cardiac surgery and its link to possible cardiac channelopathies: A case series

Samadhi Dandeniya Arachchi, Joseph Westaby, Mary N. Sheppard

Cardiac arrest with induction of anesthesia in those who appear healthy with no apparent cardiovascular disease is rare and the autopsy is essential to identify any underlying cardiac pathology. A retrospective analysis of the database of sudden cardiac deaths referred to the …

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Transgenic Domestic Pigs for research in Vascular Contributions to Cognitive Impairment and Dementia

Atticus H. Hainsworth, Love Onwuzuruike, M. V. Ramesh, Raimondo Ascione et autres

BACKGROUND: Cardiovascular disease causes vascular dementia and contributes to most clinical dementia. This is embodied in the concept of vascular contributions to cognitive impairment and dementia (VCID). The potent endogenous peptide endothelin-1 (ET1) causes small artery vasoconstriction and fibrosis. ET1 is implicated …

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Insights into the aetiology and temporal trends in cardiac mortality in the young: a 21-year review of national and registry data in the united kingdom

Raghav Bhatia, Tee Joo Yeo, H Maclachlan, Joyee Basu et autres

Abstract Background An accurate representation of the incidence and aetiology of cardiac and sudden cardiac death (SCD) is vital for healthcare policymakers to effectively allocate resources for preventative strategies. Purpose We aimed to report on the incidence and causes of cardiac and …

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2 Insights into the aetiology and temporal trends in cardiac mortality in the young: a 21-year review of national and registry data in england and wales

Raghav Bhatia, Teo Joo Yeo, Hamish MacLachlan, Chitsa Seyani et autres

Background An accurate representation of the incidence and aetiology of cardiac and sudden cardiac death (SCD) is vital for healthcare policymakers to effectively allocate resources for preventative strategies. Aim We aimed to report on the incidence and causes of cardiac and SCD …

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