Chenxia Han

Serine Stabilizes SLC7A11 and Enhances Cystine Influx to Protect Against Acute Pancreatitis

Yan Huang, FU Fei, Lingli Deng, Yiqin Wang et autres

SUMMARY Lethal sterile inflammatory diseases are linked to amino acid metabolism, but the role of serine remains unclear. Here, we show that dysregulated serine metabolism and reduced plasma serine levels correlate with disease severity of acute pancreatitis (AP) in patients and mouse …

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Serine is an endogenous brake on NEDD4-driven SLC7A11 degradation to suppress oxidative stress in sterile inflammation

Yan Huang, FU Fei, Lingli Deng, Yiqin Wang et autres

Chaihu shugan powder ameliorated chronic pancreatitis by reprogramming SMS2-mediated sphingolipid metabolism in M1 macrophages

Xiaoyin Zheng, Yijing Long, Lu Li, Jiawang Li et autres

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Geniposide, a potential therapeutical candidate for acute pancreatitis, inhibited trypsinogen-activated CBS degradation and remodeled transsulfuration metabolic flux

Ji Cheng Gao, Yijing Long, Jiawang Li, Yiqin Wang et autres

Acute pancreatitis (AP) is a potentially fatal condition with no targeted treatment options currently available. The premature activation of trypsinogen within acinar cells constitutes one of the pivotal early pathological events in AP, contributing to oxidative stress and inflammation. Disruption of the …

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Neurokinin 1 receptor inhibition alleviated mitochondrial dysfunction via restoring purine nucleotide cycle disorder driven by substance P in acute pancreatitis

Chenxia Han, Li Lu, Lin Bai, Yaling Wu et autres

Acute pancreatitis (AP) is a life-threatening gastrointestinal disorder for which no effective pharmacological treatments are currently available. One of the pharmacological targets that merits further research is the neurokinin 1 receptor (NK1R), which is found on pancreatic acinar cells and responds to …

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Unveiling the Emerging Role of Xanthine Oxidase in Acute Pancreatitis: Beyond Reactive Oxygen Species

Chenxia Han, Yaling Wu, Juan Rong, Qing Xia et autres

Acute pancreatitis (AP) is a potentially fatal acute digestive disease that is widespread globally. Although significant progress has been made in the previous decade, the study of mechanisms and therapeutic strategies is still far from being completed. Xanthine oxidase (XO) is an …

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TRPV6-mediated Store-operated Ca2+ Entry Participates in Pancreatic Acinar Cell Injury During Acute Pancreatitis

Chenxia Han, Yuncheng Luo, Zhenlu Li, Lu Li et autres

BACKGROUND & AIMS: , and its role in PACs or AP onset remains largely unknown. METHODS: signals identification. Following RNA sequencing, we examined the interaction between TRPV6 and stromal interaction molecule 1 (STIM1) at the junctions between the endoplasmic reticulum (ER) membrane …

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Traditional Chinese medicine formulas alleviated acute pancreatitis via improvement of microcirculation: A systematic review and meta-analysis

Ji Gao, Chenxia Han, Ning Dai, Wen Wang et autres

Objective: Microcirculatory disturbance is pathologically critical to acute pancreatitis (AP), which can be effectively alleviated by traditional Chinese medicine (TCM) formulas that activate blood flow. However, there has been no evidence-based research to date. Therefore, a well-designed systematic review and meta-analysis is …

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Xanthine Oxidase: A Longstanding Target in Acute Pancreatitis with New Ways

Chenxia Han, Yaling Wu, Juan Rong, Qing Xia et autres

Acute pancreatitis (AP) is a potentially fatal organ disease that is widespread globally. Although significant progress has been made in the previous decade, the study of mechanisms and therapeutic strategies is still far from being completed. Xanthine oxidase (XO) is an enzyme …

Role of Sphingosine-1-Phosphate Signaling Pathway in Pancreatic Diseases

Fei Fu, Wanmeng Li, Xiaoyin Zheng, Yaling Wu et autres

Sphingosine-1-phosphate (S1P) is a sphingolipid metabolic product produced via the phosphorylation of sphingosine by sphingosine kinases (SPHKs), serving as a powerful modulator of various cellular processes through its interaction with S1P receptors (S1PRs). Currently, this incompletely understood mechanism in pancreatic diseases including …

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Role of S1P Signaling Pathway in Pancreatic Diseases

Fei Fu, Wanmeng Li, Xiaoyin Zheng, Yaling Wu et autres

Sphingosine-1-phosphate (S1P) is a sphingolipid metabolic product produced via the phosphorylation of sphingosine by sphingosine kinases (SPHKs), serving as a powerful modulator of various cellular processes through its interaction with S1P receptors (S1PRs). Currently, the incompletely understood of mechanism in pancreatic diseases …

Role of S1P Signaling Pathway in Pancreatic Diseases

Fei Fu, Wanmeng Li, Xiaoyin Zheng, Yaling Wu et autres

Sphingosine-1-phosphate (S1P) is a sphingolipid metabolic product produced via the phosphorylation of sphingosine by sphingosine kinases (SPHKs), serving as a powerful modulator of various cellular processes through its interaction with S1P receptors (S1PRs). Currently, the incompletely understood of mechanism in pancreatic diseases …