Accès ouvert
2024
article
OpenAlex
Laura M. Schultz, Alexys Knighton, Guillaume Huguet, Zohra Saci et autres
Copy-number variants (CNVs) have been implicated in a variety of neuropsychiatric and cognitive phenotypes. We found that deleterious CNVs are less prevalent in non-European ancestry groups than they are in European ancestry groups of both the UK Biobank (UKBB) and a US …
us, ca
(code pays fourni par la source)
Accès ouvert
2024
preprint
OpenAlex
Laura M. Schultz, Alexys Knighton, Guillaume Huguet, Zohra Saci et autres
Abstract Copy number variants (CNVs), which are duplicated or deleted genomic segments larger than 1000 base pairs 1 , have been implicated in a variety of neuropsychiatric and cognitive phenotypes 2-4 . In the first large-scale of examination of genome-wide CNV frequencies …
us, ca
(code pays fourni par la source)
Accès ouvert
2022
review
OpenAlex
Alison K. Merikangas, Matthew Shelly, Alexys Knighton, Nicholas Kotler et autres
Schizophrenia is a severe, complex mental disorder characterized by a combination of positive symptoms, negative symptoms, and impaired cognitive function. Schizophrenia is highly heritable (~80%) with multifactorial etiology and complex polygenic genetic architecture. Despite the large number of genetic variants associated with …
us
(code pays fourni par la source)