Pingyuan Ge

Microglia-targeting nanosystems that cooperatively deliver Chinese herbal ingredients alleviate behavioral and cognitive deficits in Alzheimer’s disease model mice

Peng Zhou, Chao Quan, Chen Li, Ningjing Wang et autres

The effective treatment of Alzheimer's disease (AD) is challenging because of its complex and controversial pathological mechanisms. Moreover, multiple barriers, such as the blood-brain barrier (BBB), reduce drug delivery efficiency. Microglia-related neuroinflammation has recently attracted increasing attention as a possible cause of …

cn, us (code pays fourni par la source)

Berbamine targets the FKBP12-rapamycin-binding (FRB) domain of the mTOR complex to promote microglial autophagy and ameliorate neuroinflammation in Alzheimer’s disease

Pingyuan Ge, Siqi Guo, Pingping Wang, Peng Zhou et autres

cn (code pays fourni par la source)

Coptisine improves LPS-induced anxiety-like behaviors by regulating the Warburg effect in microglia via PKM2

Yiyu Qi, Xin Zhao, Weizhen Wu, Ningjing Wang et autres

Neuroinflammation mediated by microglia is considered the primary cause and pathological process of anxiety. Abnormal glycolysis of microglia is observed during microglia activation. However, whether regulating the Warburg effect in microglia can effectively intervene anxiety and its potential mechanisms have not been …

cn, us (code pays fourni par la source)

Coptisine Improves Anxiety-Like Behaviors by Regulating the Warburg Effect in Microglia Via Pkm2

Yiyu Qi, Xin Zhao, Weizhen Wu, Ningjing Wang et autres

cn, us (code pays fourni par la source)

Coptisine Improves Anxiety-Like Behaviors by Regulating the Warburg Effect in Microglia Via Pkm2

Yiyu Qi, Xin Zhao, Weizhen Wu, Ningjing Wang et autres

cn, us (code pays fourni par la source)

An Exosome-Based Therapeutic Strategy Targeting Neuroinflammation in Alzheimer’s Disease with Berberine and Palmatine

Xin Zhao, Pingyuan Ge, Shaohua Lei, Siqi Guo et autres

Introduction: Neuroinflammation is one of the major pathogeneses in Alzheimer's disease (AD) and mainly involves abnormal inflammatory activation of microglia by multiple pathological stimuli. The treatment of AD remains a major challenge due to the multifactorial characterization of AD and the inefficient …

cn (code pays fourni par la source)

Uncovering the Potential Mechanisms of Coptis chinensis Franch. for Serious Mental Illness by Network Pharmacology and Pharmacology-Based Analysis

Yiyu Qi, Sai‐jia Ni, Heng Xia, Shu‐Yue Qu et autres

Yiyu Qi,1 Saijia Ni,2 Xia Heng,1 Shuyue Qu,1 Pingyuan Ge,1 Xin Zhao,1 Zengying Yao,2 Rui Guo,3 Nianyun Yang,1 Qichun Zhang,2 Huaxu Zhu1 1Department of Traditional Chinese Medicine Processing and Preparation, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, People’s Republic of China; 2Department …

cn (code pays fourni par la source)

Potential Mechanism of S. baicalensis on Lipid Metabolism Explored via Network Pharmacology and Untargeted Lipidomics

Pingyuan Ge, Yiyu Qi, Shu‐Yue Qu, Xin Zhao et autres

Background: S. baicalensis , a traditional herb, has great potential in treating diseases associated with aberrant lipid metabolism, such as inflammation, hyperlipidemia, atherosclerosis and Alzheimer’s disease. Aim of the Study: To elucidate the mechanism by which S. baicalensis modulates lipid metabolism and …

cn (code pays fourni par la source)

Analysis of Antidepressant Activity of Huang-Lian Jie-Du Decoction Through Network Pharmacology and Metabolomics

Shu‐Yue Qu, Xiaoyue Li, Heng Xia, Yiyu Qi et autres

Depressive disorder is a common mental disorder characterized by depressed mood and loss of interest or pleasure. As the Herbal medicines are mainly used as complementary and alternative therapy for depression. This study aimed at exploring antidepressant activity of Huang-lian Jie-du Decoction …

cn (code pays fourni par la source)