Siqi Guo

Author Correction: A peptide-centric local stability assay enables proteome-scale identification of the protein targets and binding regions of diverse ligands

Kejia Li, Shijie Chen, Keyun Wang, Yan Wang et autres

cn, de, se (code pays fourni par la source)

Heterostructuring as Gateway to Electron Doping of Nickelate Superconductors

Anonymous, Motoharu Kitatani, Guiwen Jiang, Siqi Guo et autres

Despite enormous expenditures in the research field, the electron-doped side of nickelate superconductors remains uncharted territory. Substituting the trivalent rare-earth cations by a tetravalent one hitherto failed. Here, we demonstrate by first-principles calculations a disorder-free route to electron dope Ruddlesden-Popper nickelates. When …

jp, de, cn, at (code pays fourni par la source)

High-sensitivity pan-cancer AI assessment of lymph node metastasis via uncertainty quantification

Xiaodong Wang, Ying Chen, Xiaohong Liu, Cen Qiu et autres

The histological heterogeneity of primary tumors across the pan-cancer spectrum poses a formidable barrier to accurate lymph node metastasis assessment, often causing AI systems to make "overconfident errors" on rare variants that lead to missed diagnoses. To address this, we present UPATHLN, …

cn (code pays fourni par la source)

Targeting Prolyl 3-hydroxylase 1 inhibits pancreatic cancer progression and macrophage immunity

Panzhu Bai, Chengmin Liu, Changying Fu, Renwei Cai et autres

Pancreatic ductal adenocarcinoma remains one of the most formidable challenges in oncology, with limited treatment options and a poor prognosis. Understanding the key pathways affecting cancer progression is crucial for the development of therapeutic strategies. Here, we reveal a pivotal role of …

cn, us (code pays fourni par la source)

Silicon nitride-enhanced poly(p-phenylene benzobisoxazole) nanofiber film with high thermal conductivity and flame retardancy

Chengzhi Guo, Chaofeng Chen, Siqi Guo, Ziyang Wang et autres

cn (code pays fourni par la source)

Multi-omics profiling reveals cholic acid-mediated immunosuppression driven by peritumoral ductular reactions in hepatocellular carcinoma

Qianhui Xu, Hang Chen, Ganggang Wang, Xiaodong Wang et autres

cn (code pays fourni par la source)

High-Sensitivity Pan-Cancer AI Assessment of Lymph Node Metastasis via Uncertainty Quantification

X Wang, Ying Chen, Xiaohong Liu, Cen Qiu et autres

Abstract The histological heterogeneity of primary tumours across the pan-cancer spectrum poses a formidable barrier to accurate lymph node metastasis assessment, often causing AI systems to make “overconfident errors” on rare variants that lead to missed diagnoses. To address this, we present …

cn (code pays fourni par la source)

Achieving decoupled thermal and electrical transport in BaLiX (X = P, As, Sb, Bi) Zintl phases compounds via anion engineering

Ning Wang, Jincheng Yue, Hui Zhang, Siqi Guo et autres

cn, es (code pays fourni par la source)

Morphological Landscape Mapping Decodes Pathological Heterogeneity and Proteomic Programs in HCC

Xiaodong Wang, Yifei Cheng, Jinda Li, Jing Han et autres

Abstract Background & Aims Intratumour heterogeneity (ITH) drives the clinical trajectory of HCC, yet routine pathology relies on global classifications that often mask local architectural diversity. We developed an unsupervised artificial intelligence framework to deconvolute HCC histology into a comprehensive lexicon of …

cn, us (code pays fourni par la source)

RELA Haploinsufficiency Manifesting as an Atypical Phenotype of Crohn’s Disease

Noa Tal, Liran Baram, Arne Gehlhaar, Weihong Gu et autres

BACKGROUND: Mutations in RELA, a key component of NF-κB signaling, are associated with dysregulated immune responses and inflammatory disorders. While immunodeficiency phenotypes associated with RELA haploinsufficiency have been reported, gastrointestinal manifestations remain poorly described. This study aimed to characterize the clinical, genomic, …

il, de, us, nl (code pays fourni par la source)

Bidirectional optimization of transport properties for thermoelectric performance via hydrostatic pressure in chalcopyrite Ag X Te 2 ( X = In , Ga )

Siqi Guo, Jincheng Yue, Jiongzhi Zheng, Ning Wang et autres

Pressure tuning has emerged as a powerful strategy for manipulating the thermoelectric properties of materials by inducing structural and electronic modifications. Herein, we systematically investigate the transport properties and thermoelectric performance concerning lattice distortions induced by hydrostatic pressure in Ag-based chalcopyrite $\mathrm{Ag}X{\mathrm{Te}}_{2}$ …

cn, us, hk, gb (code pays fourni par la source)

Microglia-targeting nanosystems that cooperatively deliver Chinese herbal ingredients alleviate behavioral and cognitive deficits in Alzheimer’s disease model mice

Peng Zhou, Chao Quan, Chen Li, Ningjing Wang et autres

The effective treatment of Alzheimer's disease (AD) is challenging because of its complex and controversial pathological mechanisms. Moreover, multiple barriers, such as the blood-brain barrier (BBB), reduce drug delivery efficiency. Microglia-related neuroinflammation has recently attracted increasing attention as a possible cause of …

cn, us (code pays fourni par la source)