Nicole Tanenbaum

The human protein SETD3 is required for replication organelle formation during enterovirus infection

Nicole Tanenbaum, Carette, Jan, 1971-, Karla Kirkegaard, Tino Pleiner et autres

A Mixed‐Methods Analysis of a Student‐Led Near‐Peer Mentorship Program for the National Science Foundation Graduate Research Fellowship Program: Findings and a Replicable Framework

Courtney Peña‐Lima, Nicole Tanenbaum, Lily Wen Xu, Crystal M. Botham

Grant writing is a critical skill if pursuing a research career. However, not all PhD students receive formal grant writing training as it can be costly for institutions to develop and maintain. To address this need, we implemented a student-led, near-peer mentorship …

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A community-led initiative to de-risk and advance Parkinson’s disease therapeutic targets

Jonathan Behr, Ryan Birol, Cornelis Blauwendraat, Bradford H. Casey et autres

Identifying effective therapeutic targets for Parkinson's disease (PD) is challenging, with no current disease-modifying therapies available. To address this, The Michael J. Fox Foundation for Parkinson's Research launched the Targets to Therapies (T2T) initiative, uniting experts to prioritize and validate promising targets. …

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Antigenic Characterization of H1N1 Influenza Viruses That Circulated During the 2019–2020 Season in Philadelphia, Pennsylvania

Lydia M. Mendoza, Elizabeth M. Anderson, Ashley Sobel Leonard, Alexander G. McFarland et autres

BACKGROUND: Multiple clades of H1N1 influenza A viruses (IAVs) circulated during the 2019-2020 season. Here, we completed serological assays to determine the specificities of serum antibodies from humans infected with viruses from different H1N1 clades during the 2019-2020 season. METHODS: We collected …

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Author response for "Antigenic Characterization of H1N1 Influenza Viruses That Circulated During the 2019–2020 Season in Philadelphia, Pennsylvania"

Lydia M. Mendoza, Elizabeth M. Anderson, Ashley Sobel Leonard, Alexander G. McFarland et autres

Immunologic Predictors of Vaccine Responsiveness in Patients With Lymphoma and Chronic Lymphocytic Leukemia

Elise A. Chong, Kingsley Gideon Kumashie, Emeline R Chong, Joseph Fabrizio et autres

Patients with B-cell lymphomas have altered cellular components of vaccine responses due to malignancy and therapy, and the optimal timing of vaccination relative to therapy remains unknown. SARS-CoV-2 vaccines created an opportunity for new insights in vaccine timing because patients were challenged …

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Immunologic predictors of vaccine responsiveness in patients with lymphoma and CLL

Elise A. Chong, Kingsley Gideon Kumashie, Emeline R. Chong, Joseph Fabrizio et autres

ABSTRACT Patients with B-cell lymphomas have altered cellular components of vaccine responses due to the malignancies and therapies. The optimal timing of vaccine administration relative to chemotherapy and immunotherapy remains unknown. The SARS-CoV-2 vaccine campaign created a unique opportunity to gather insights …

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Asparagine biosynthesis as a mechanism of increased host lethality induced by Serratia marcescens in simulated microgravity environments

Rachel Gilbert, Nicole Tanenbaum, Sharmila Bhattacharya

While studies have shown an increase in pathogenicity in several microbes during spaceflight and after exposure to simulated microgravity, the mechanisms underlying these changes in phenotype are not understood across different pathogens, particularly in opportunistic pathogens. This study evaluates the mechanism for …

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Efficient recall of Omicron-reactive B cell memory after a third dose of SARS-CoV-2 mRNA vaccine

Rishi R. Goel, Mark M. Painter, Kendall A. Lundgreen, Sokratis A. Apostolidis et autres

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Efficient recall of Omicron-reactive B cell memory after a third dose of SARS-CoV-2 mRNA vaccine

Rishi R. Goel, Mark M. Painter, Kendall A. Lundgreen, Sokratis A. Apostolidis et autres

Abstract Despite a clear role in protective immunity, the durability and quality of antibody and memory B cell responses induced by mRNA vaccination, particularly by a 3 rd dose of vaccine, remains unclear. Here, we examined antibody and memory B cell responses …

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What genes are differentially expressed in individuals with schizophrenia? A systematic review

Alison K. Merikangas, Matthew Shelly, Alexys Knighton, Nicholas Kotler et autres

Schizophrenia is a severe, complex mental disorder characterized by a combination of positive symptoms, negative symptoms, and impaired cognitive function. Schizophrenia is highly heritable (~80%) with multifactorial etiology and complex polygenic genetic architecture. Despite the large number of genetic variants associated with …

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mRNA vaccines induce durable immune memory to SARS-CoV-2 and variants of concern

Rishi R. Goel, Mark M. Painter, Sokratis A. Apostolidis, Divij Mathew et autres

Immune memory after vaccination Vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has proven highly effective at preventing severe COVID-19. However, the evolution of viral variants, and waning antibody levels over time, raise questions regarding the longevity of vaccine-induced immune protection. …

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