Laura Toba

Liraglutida, agonista del receptor de glp-1, regula la expresión de los componentes hepáticos de ras en crías de ratas sometidas perinatalmente a restricción calórica.

Zainab Mastoor, Juan Fandiño, Laura Toba, Lucas C. González-Matías et autres

GLP-1 receptor agonist ameliorates experimental lung fibrosis

Juan Fandiño, Laura Toba, Lucas C. González-Matías, Yolanda Diz-Chaves et autres

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and fatal lung disease. This disease is characterized by an excessive accumulation of extracellular matrix deposition that modify normal lung physiology. Up to date, there are not efficient therapeutic tools to fight IPF. Glucagon-like …

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Perinatal Undernutrition, Metabolic Hormones, and Lung Development

Juan Fandiño, Laura Toba, Lucas C. González-Matías, Yolanda Diz-Chaves et autres

Maternal and perinatal undernutrition affects the lung development of litters and it may produce long-lasting alterations in respiratory health. This can be demonstrated using animal models and epidemiological studies. During pregnancy, maternal diet controls lung development by direct and indirect mechanisms. For …

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Liraglutide Enhances the Activity of the ACE-2/Ang(1–7)/Mas Receptor Pathway in Lungs of Male Pups from Food-Restricted Mothers and Prevents the Reduction of SP-A

Juan Fandiño, A. A. Vaz, Laura Toba, Marina Romaní‐Pérez et autres

In utero growth restriction and being born small for gestational age are risk factors for respiratory morbidity. IUGR (in utero growth retardation) is associated to overall reduction in lung weight, surfactant content and activity, impaired maturation of the alveolar type II cells, …

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The GLP-1 analog, liraglutide prevents the increase of proinflammatory mediators in the hippocampus of male rat pups submitted to maternal perinatal food restriction

Yolanda Diz-Chaves, Laura Toba, Juan Fandiño, Lucas C. González-Matías et autres

BACKGROUND: Perinatal maternal malnutrition is related to altered growth of tissues and organs. The nervous system development is very sensitive to environmental insults, being the hippocampus a vulnerable structure, in which altered number of neurons and granular cells has been observed. Moreover, …

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GLP-1 increases the availability of substrates and prioritizes the use of lipids in muscle metabolism

Laura Toba, Juan Fandiño, Yolanda Diz-Chaves, Lucas Carmelo Gonzalez-Matias et autres

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

Liraglutide treatment prevented the increased expression of proinflammatory cytokines in the hippocampus of male pups in a perinatal stress model of food restriction

Yolanda Diz-Chaves, Laura Toba, Juan Fandiño, Lucas C. González-Matías et autres

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

GLP-1 acutely regulates carbohydrate and lipid metabolic routes in the liver

Laura Toba, Yolanda Diz-Chaves, Juan Fandiño, Hugo Ogando et autres

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

Liraglutide prevents right ventricle hypertrophy by avoiding ACE1 & ACE2 reduction in an experimental model of idiopathic pulmonary fibrosis

Juan Fandiño, Laura Toba, Hugo Ogando, Yolanda Diz et autres

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

Stressing diabetes? The hidden links between insulinotropic peptides and the HPA axis

Yolanda Diz-Chaves, Manuel Gil‐Lozano, Laura Toba, Juan Fandiño et autres

Diabetes mellitus exerts metabolic stress on cells and it provokes a chronic increase in the long-term activity of the hypothalamus-pituitary-adrenocortical (HPA) axis, perhaps thereby contributing to insulin resistance. GLP-1 receptor (GLP-1R) agonists are pleiotropic hormones that not only affect glycaemic and metabolic …

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Liraglutide increases surfactant proteins (SPA & SPB) and angiotensin-converting enzymes (ACE & ACE2) expression in a rat model of acute lung injury by bleomycin

Juan Fandiño, Laura Toba, María González-Núñez, Yolanda Diz-Chaves et autres

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

Emotional behavior is modulated by liragutide in an age and gender manner in rats from food restriction mothers

Laura Toba, Juan Fandiño, María González-Núñez, Lucas C. González-Matías et autres

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)