Colin B. Van Orman

Genetic Testing to Inform Epilepsy Treatment Management From an International Study of Clinical Practice

Dianalee McKnight, Ana Morales, Kathryn E. Hatchell, Sara L. Bristow et autres

Importance: It is currently unknown how often and in which ways a genetic diagnosis given to a patient with epilepsy is associated with clinical management and outcomes. Objective: To evaluate how genetic diagnoses in patients with epilepsy are associated with clinical management …

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Pretreatment behavior and subsequent medication effects in childhood absence epilepsy

Ruth C. Shinnar, Shlomo Shinnar, Avital Cnaan, Peggy O. Clark et autres

OBJECTIVE: To characterize pretreatment behavioral problems and differential effects of initial therapy in children with childhood absence epilepsy (CAE). METHODS: The Child Behavior Checklist (CBCL) was administered at baseline, week 16-20, and month 12 visits of a randomized double-blind trial of ethosuximide, …

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Obesity and overweight as CAE comorbidities and differential drug response modifiers

Ravindra Arya, Catherine W. Gillespie, Avital Cnaan, Mahima Devarajan et autres

OBJECTIVE: This study examined whether overweight and obesity are pretreatment comorbidities and predictors of short-term drug response in newly diagnosed untreated childhood absence epilepsy (CAE). We also examined whether dietary intake accounts for observed pretreatment body mass index (BMI) distribution. METHODS: Pretreatment …

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Long-term outcomes of generalized tonic-clonic seizures in a childhood absence epilepsy trial

Shlomo Shinnar, Avital Cnaan, Fengming Hu, Peggy O. Clark et autres

OBJECTIVE: To determine incidence and early predictors of generalized tonic-clonic seizures (GTCs) in children with childhood absence epilepsy (CAE). METHODS: Occurrence of GTCs was determined in 446 children with CAE who participated in a randomized clinical trial comparing ethosuximide, lamotrigine, and valproate …

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Infant botulism in the age of botulism immune globulin

J. Thompson, Francis Filloux, Colin B. Van Orman, Kathryn J. Swoboda et autres

Infant botulism causes acute bulbar dysfunction, weakness, and respiratory failure in infants living in endemic regions of the United States. Until Food and Drug Administration approval of botulism immune globulin (BIG) in October 2003, management of infant botulism had changed little since …

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Clinicopathological Review: Tumefactive Demyelination in a 12-year-old Girl

Richard C. E. Anderson, E. Sander Connolly, Ricardo J. Komotar, William J. Mack et autres

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Cerebral Sinovenous Thrombosis in Children: Another Reason to Treat Iron Deficiency Anemia

Susan Benedict, Joshua L. Bonkowsky, Joel A. Thompson, Colin B. Van Orman et autres

Iron deficiency anemia is a rare cause of cerebral sinovenous thrombosis in children. We report three cases of cerebral sinovenous thrombosis and iron deficiency anemia treated at Primary Children's Medical Center in Salt Lake City, Utah, between 1998 and 2001. The children …

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Neurologic variant of epidermal nevus syndrome with a facial lipoma

Conleth A. Egan, Kappa P. Meadows, Colin B. Van Orman, Sheryll L. Vanderhooft

A 1-year-old girl presented for evaluation of a linear plaque on her forehead. She was born at 36 weeks' gestation following an uncomplicated pregnancy and delivery. At birth, she was noted to have an enlarged right cheek. She had no seizure history, …

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