William J. Mack

Timing of Middle Meningeal Artery Embolization and Surgery: Analysis of the EMBOLISE Trial

Maxim Mokin, Jared Knopman, Jason M. Davies, Ameer E Hassan et autres

BACKGROUND: The EMBOLISE trial (The Embolization of the Middle Meningeal Artery With Onyx Liquid Embolic System in the Treatment of Subacute and Chronic Subdural Hematoma) demonstrated that middle meningeal artery embolization as an adjunct to surgical drainage reduces recurrence of symptomatic subacute …

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Low Brain Levels of Dietary Polyphenols and Their Conjugates: Reassessing Mechanisms of Alzheimer’s Disease Prevention

Roshni Sharma, Kristina Shkirkova, William J. Mack, Rayudu Gopalakrishna

Dietary polyphenols such as quercetin, resveratrol, and (-)-epigallocatechin-3-gallate (EGCG) have been shown to be neuroprotective in epidemiologic and experimental studies of Alzheimer’s disease (AD), though clinical evidence remains limited. This re-view highlights the importance of studying glucuronide and sulfate conjugates of these …

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Short-term outcomes and hospitalization cost associated with flow diversion versus coil embolization for unruptured aneurysms: A national assessment

Jonathan Dallas, Michelle Lin, David J. Coté, Anadjeet S. Khahera et autres

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Acute air pollution exposure downregulates ferroptosis protection genes causing increases in amyloid peptides and lipid peroxidation

Kristina Shkirkova, Marc Vermulst, Constantinos Sioutas, William J. Mack et autres

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Comorbid depression is associated with non-routine discharge following treatment of unruptured cerebral aneurysms

Jane Han, Jonathan Dallas, Angela M. Tang-Tan, Michelle Lin et autres

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The Role of Diagnostic Spinal Angiography for Thoracoabdominal Aortic Aneurysms: A Clinical Case Series in Patients Undergoing Staged Complex Endovascular Repairs

Michelle Lin, Sarah Sternbach, Keiko M. Kang, Vincent Nguyen et autres

BACKGROUND AND OBJECTIVES: Spinal cord ischemia affects up to 40% of patients undergoing repair of complex thoracoabdominal aortic aneurysms (TAAAs). Preoperative identification of key segmental spinal artery contributors may guide the design of custom fenestrated graft constructs or extra-anatomic bypass. Despite the …

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Surgical and Other Therapeutic Minimalism: Reducing the Risk

Vincent Nguyen, Jonathan Dallas, Saman Sizdahkhani, Alexandra N. Demetriou et autres

This chapter provides an overview of minimally invasive approaches in neurosurgery. It explores the history of minimally invasive techniques and their current state and discusses the authors’ beliefs regarding future advancements. We highlight the transformative impact of minimally invasive approaches, including improved …

Vessel wall imaging-dedicated deep learning (VWI-DL): Toward a 5-min clinically robust MR protocol

Pengcheng Wang, Junzhou Chen, Zhen Wang, Nasim Sheikh‐Bahaei et autres

Motivation: Long scan times (8-12 minutes) in whole-brain MR vessel wall imaging (VWI) cause patient discomfort and motion artifacts, limiting clinical utilization. Faster VWI with preserved image quality is highly desirable. Goal(s): To develop a VWI-dedicated deep learning model to substantially accelerate …

Clinical outcomes and independently adjudicated results of M2 aspiration thrombectomy: a subgroup analysis from the Imperative Trial

Justin Mascitelli, Reade De Leacy, William J. Mack, Raul G. Nogueira et autres

BACKGROUND: The ESCAPE-MeVO (Endovascular Treatment to Improve Outcomes for Medium Vessel Occlusions) and DISTAL (Endovascular Therapy plus Best Medical Treatment vs Best Medical Treatment Alone for Medium Vessel Occlusion Stroke) trials failed to demonstrate the superiority of endovascular thrombectomy over best medical …

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A Bivalent Protease-Activated Receptor-Derived Peptide Mimics Neuronal Anti-Apoptotic Activity of Activated Protein C

Abhay P. Sagare, Youbin Kim, Kassandra Kisler, Ruslan Rust et autres

Activated protein C (APC) exerts anticoagulant and cytoprotective cell signaling activities. APC's cell signaling requires protease-activated receptor (PAR) PAR1 and PAR3, and APC's PAR cleavages generate peptides capable of agonizing biased G-protein coupled receptor (GPCR) cytoprotective signaling, resulting in anti-inflammatory and anti-apoptotic …

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Stroke thrombectomy with a novel reperfusion system including a 0.088′′ aspiration catheter: the Imperative Trial

William J. Mack, Reade De Leacy, Jonathan A Grossberg, Shahram Majidi et autres

BACKGROUND: Mechanical thrombectomy is the standard of care for large vessel occlusion (LVO) stroke, yet most device trials focus on individual technologies rather than complete systems. OBJECTIVE: To evaluate the safety and efficacy of the Zoom Reperfusion System compared with performance goals …

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Semi-automated tortuosity measurements confirm generalizability of IMPERATIVE trial results to real-world patients with acute ischemic stroke undergoing thrombectomy

Maxim Mokin, William J. Mack, Raul G. Nogueira, Jonathan A Grossberg et autres

Background Criticism of clinical trials of endovascular therapy of acute ischemic stroke due to large vessel occlusion includes their lack of generalizability. We aimed to evaluate the impact of vessel tortuosity on the outcomes of large-bore and super-bore aspiration catheters in the …

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