Yuan Chang

Cell Cycle Regulation of Merkel Cell Polyomavirus Replication and Genome Inheritance in Single Cells

Steven W. Smeal, Hongzhao Zhou, Md Musaddaqul Hasib, Bizunesh Abere et autres

Abstract Merkel cell polyomavirus (MCV) establishes a near-ubiquitous, asymptomatic infection in humans but on rare occasions drives Merkel cell carcinoma, an aggressive skin cancer. How MCV replication is coordinated with host cell-cycle progression, and how this coordination shapes infected-cell fate, has remained …

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Pharmacologic reversion of Merkel cell carcinoma via CBP/p300 inhibition

Joseph L. Collura, Kuan Cheok Lei, Mitalee Chandra, Thibault Kervarrec et autres

Merkel cell polyomavirus (MCV) T antigen functions as an oncoprotein that drives the transformation of Merkel cell carcinoma (MCC) cells by activating transcription factors involved in cell proliferation. The viral T antigen promoter requires the activity of the cellular coactivator CREB-binding protein …

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Editing-overexpression coupling system synchronizes photosynthetic enhancement, yield optimization, and abiotic stress tolerance in rice

Suting Wu, Xuean Cui, Yuan Chang, Zhiwei Wang et autres

Source-sink coordination serves as the foundation for improving crop yield. Current research primarily focuses on individual factors, such as increasing the source or expanding the sink, which often leads to disrupted source-sink balance, causing trade-offs among photosynthesis, yield, and stress response. To …

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Mechanism of cancer-associated fibroblast-driven thyroid cancer dedifferentiation via the ZFP57-PKM2 axis-mediated lactate secretion and therapeutic intervention with Resveratrol

Xiaoyu Ji, Chengzhou Lv, Xian Wu, Hongpeng Wu et autres

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The lung pre‐metastatic niche in osteosarcoma: Mechanism and therapeutic intervention

Daqing Wang, Baosheng Yin, Yuan Chang, Pak Hyon‐U et autres

Osteosarcoma (OS), the most common primary malignant bone tumor in children and adolescents, is characterized by its aggressive nature, high metastatic potential, and poor prognosis. The pre-metastatic niche (PMN) plays a crucial role in driving OS metastasis. This review provides an overview …

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Clinicopathological and molecular correlates of clinical benefit from disitamab vedotin (RC48), a HER-2-targeting antibody-drug conjugate, in metastatic urothelial carcinoma: a multi-center, real-world study

Zhaopei Liu, Kaifeng Jin, Zhen-Bin Xu, Han Zeng et autres

INTRODUCTION: Disitamab Vedotin (DV), a HER-2-targeting antibody-drug conjugate, has exhibited substantial clinical advantages in individuals with metastatic urothelial carcinoma (mUC). Nonetheless, the extent of therapeutic efficacy in real-world scenarios for mUC patients and the specific patient profiles with the most benefit from …

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SNX25-mediated regulation of NGF by Periploca sepium periplosides from Xiangjiapi in macrophage-dependent anti-nociception

Yuan Chang, Mengru Guo, Wenlong Yuan, Yong Hu et autres

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A 10-Bit 2-GS/s Voltage–Time-Pipelined Hybrid ADC with One-Hot Background Calibration Scoring > 60-dB SFDR in 28-nm CMOS

Yuan Chang, Chenghao Zhang, Yihang Yang, Maliang Liu et autres

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Pyruvate Dehydrogenase Kinase 4 Underlies the Metabolic Disorder of Cardiomyocytes in Patients With Hypertrophic Cardiomyopathy From Hypertrophy to Heart Failure

Xiumeng Hua, Zhe Sun, Congrui Wang, Hao Cui et autres

Background Hypertrophic cardiomyopathy (HCM), characterized by ventricular hypertrophy and fibrosis, frequently progresses to heart failure. Although metabolic dysregulation is implicated in HCM pathophysiology, the role of PDK4 (pyruvate dehydrogenase kinase 4), a key regulator of cardiac glucose and fatty acid oxidation, in …

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Primary Sequence-Intrinsic Immune Evasion by Viral Proteins Guides CTL-Based Vaccine Strategies

Li Wan, Masahiro Shuda, Yuan Chang, Patrick S. Moore

Viruses use a range of sophisticated strategies to evade detection by cytotoxic T-lymphocytes (CTLs) within host cells. Beyond elaborating dedicated viral proteins that disrupt the MHC class I antigen-presentation machinery, some viruses possess intrinsic, cis-acting genome-encoded elements that interfere with antigen processing …

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Real-Time Dynamics Simulation of the Upper Limb Musculoskeletal Multibody System Based on Semi-Recursive Method*

Yuan Chang, Jianqiao Guo, Qiang Tian

Musculoskeletal biomechanics simulation is crucial for evaluating the risk of muscle fatigue and joint injuries among manual handling workers caused by high-intensity repetitive upper limb operations. This study proposed an inverse dynamics simulation framework for the upper limb musculoskeletal system based on …

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A 40GS/s 8bit Time-Interleaved Time-Domain ADC Featuring SFDR-Enhanced Sample-and-Hold Circuit and Power-Efficient Adaptive Pulse Generator in 28nm CMOS

Chenghao Zhang, Maliang Liu, Yuan Chang, Yihang Yang et autres

This paper reports a 40 GS/s 8b Time-Interleaved (TI) time-domain gated-ring-oscillator analog-to-digital converter (GRO-ADC). The smallest interleaving number of 32 is achieved with a single 8-bit GRO-ADC operating at $1.25 \mathrm{GS} / \mathrm{s}$ in 28 nm CMOS, leading to a low routing …

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