Xiumeng Hua

PPIA-CD147 Interaction Mediates Immune-induced Cardiomyocyte Hypertrophy After Cardiac Xenotransplantation

Yuan Chang, Yixuan Sheng, Renjie Tang, Xiumeng Hua et autres

BACKGROUND: Pathological myocardial hypertrophy constitutes a major impediment to the prolonged survival of heart xenotransplantation. Conventional approaches, including intensive antihypertensive therapy and growth factor receptor knockout, have demonstrated limited efficacy in mitigating this maladaptive remodeling. Immune-mediated injury is the fundamental cause of …

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VCAM-1–targeting peptide assemblies protect vascular endothelium and prolong cardiac xenograft survival

Yijing Li, Haitao Zhang, Zhe Sun, Kai Xing et autres

Cardiac xenotransplantation represents a promising strategy to address the shortage of donor hearts, yet endothelial cell dysfunction remains a major obstacle to long-term graft survival. Using integrated single-cell RNA sequencing in a porcine-to-primate xenotransplantation model, we identified a VCAM-1 + endothelial subpopulation …

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Time-resolved proteolipidomics of the human aorta identifies stage-specific lipid-protein modules across development and aging

H J Cui, Sin Man Lam, Yiqi Zhao, Yuan Chang et autres

An established vascular network is a prerequisite to ensuring an optimal supply of oxygen and nutrients for sustaining developmental events and systemic function. Herein, we construct a time-resolved proteolipidomic atlas of the aorta across the human life cycle. trans-omics integration reveals that …

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TNNT2 Mutation Affects the Progression of Dilated Cardiomyopathy in Children

Shun Liu, Han Mo, Xiao Chen, Hao Cui et autres

BACKGROUND: Genetic mutations play an important role in pediatric cardiomyopathy. However, whether different genetic factors contribute to the rate of disease progression remains unclear. OBJECTIVES: To explore the role of genetic mutations in disease progression in pediatric cardiomyopathy. METHODS: We collected basic …

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Life-span–dependent transcriptional dynamics of the human heart

Hao Jia, Xiao Chen, Yuan Chang, Yifan Wang et autres

The human heart undergoes continuous transcriptional remodeling from development through aging, yet the cellular and regulatory features governing this process remain incompletely defined. Here, we generated a single-nucleus RNA sequencing atlas of 442,239 nuclei from 54 nonfailing myocardial tissues of 29 individuals …

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MYC-Driven Glycolysis in TNFRSF4+ CD4+ T Cells Underlies Heightened Rejection Susceptibility of Cardiac vs. Renal Allografts

Peiyuan Li, Yuan Chang, Xiaofei Zhu, Xiao Chen et autres

BACKGROUND: Cardiac allografts show poorer long-term survival and decreased tolerance compared to renal allografts, but the underlying mechanisms remain unclear. METHODS AND RESULTS: We established heterotopic heart and kidney allotransplantation models in Bama miniature pigs. Single-cell RNA sequencing (scRNA-seq) was performed to …

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End-stage valvular heart disease requiring heart transplantation: risk profile, surgical modifiers, and myocardial pathology

Yifan Wang, Yiqi Zhao, Weiteng Wang, Hao Jia et autres

BACKGROUND: End-stage valvular heart disease (VHD) constitutes a small but high-risk subset of heart transplant (HTx) recipients, and data describing their natural history and determinants of progression to HTx are limited. We aimed to characterize the clinical, genetic, surgical, and pathological substrates …

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The metabolic change trajectory of skeletal muscle during the life cycle: arteriovenous metabolomics

Siyuan Huang, Yu Gu, Guogang Xu, Jing Han et autres

Siyuan Huang, Yuanping Gu, Guogang Xu, Jing Han, Hao Jia, Yifan Wang, Xiao Chen, Ningning Zhang, Xiumeng Hua, Han Mo, Zhe Sun, Fei Dong, Yuan Chang, Hao Cu

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SPP1high fibrogenic macrophages mediate protective fibrotic remodeling and promote vascular stability in hypertension-associated aortic dissection

Shuai Zhao, Xiumeng Hua, Dongxing Zhu, Peiyuan Li et autres

Hypertension-associated aortic dissection (HTN-AD) features intense immune activation and extracellular matrix disruption, yet the cellular programs that promote aortic-wall stabilization remain unclear. We aimed to identify macrophage states associated with vascular integrity and to determine whether these states could be mechanistically or …

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Inhibition of T cell polyamine metabolism promotes transplant acceptance by modulating cytotoxic CD8+ T cell differentiation

Renjie Tang, Yuan Chang, Yuqi An, Dan Shan et autres

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Therapeutic base editing alleviates restrictive cardiomyopathy

Chong Chang, Xiulin Zhang, Xiaoqi Fan, Yuan Chang et autres

Restrictive cardiomyopathy (RCM) is a severe cardiac disorder characterized by impaired ventricular filling and diastolic dysfunction, with mutations in sarcomeric proteins representing major causative factors. Mutations of TNNI3 gene (e.g., p.R192H) constitute major genetic causes of RCM, particularly affecting pediatric patients and …

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Development of early diagnostic strategies by targeting CXCR3 following heart transplantation

Yuan Chang, Peiyuan Li, Zhe Sun, Weiteng Wang et autres

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