Pongsakorn Thawornpan

Aberrant sphingosine-1-phosphate receptor 1 expression on activated naive B cells associated with disease activity and lupus nephritis in systemic lupus erythematosus

Pachara Tianpothong, Piyawan Kochayoo, Thanitta Suangtamai, Sasicha Suksapan et autres

BACKGROUND: Systemic lupus erythematosus (SLE) is characterized by the immune system producing autoantibodies that target the body's own cells and tissues, leading to inflammation and tissue damage. Sphingosine-1-phosphate receptor 1 (S1PR1) plays a crucial role in regulating immune cell trafficking, and its …

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A functional crosstalk between circulating follicular helper 2 T cells and memory B cells drives anti-Plasmodium vivax antibodies

Zulfa Zahra Salsabila, Piyawan Kochayoo, Tipanan Khunsri, Pachara Tianpothong et autres

BACKGROUND: The induction of long-term humoral immune responses depends upon the interaction between T follicular helper (Tfh) and B cells in germinal centers, leading to development of memory B cells (MBCs) and class-switched antibodies. Expansion and activation of circulating Tfh2 (cTfh2) cells …

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Function of follicular helper 17 T cells in driving B cells for anti-DNA autoantibody production in patients with SLE

Tipanan Khunsri, Pachara Tianpothong, Piyawan Kochayoo, Pongsakorn Thawornpan et autres

BACKGROUND: Follicular helper T (TFH) cells play a crucial role in the dysregulated antibody responses in SLE. Circulating TFH17 (cTFH17) subsets are elevated in active lupus, and their frequency is associated with increased disease activity and autoantibody levels, indicating their potential role …

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Correction: Cross-reactive inhibitory antibody and memory B cell responses to variant strains of Duffy binding protein II at post-Plasmodium vivax infection

Pongsakorn Thawornpan, Siriruk Changrob, Piyawan Kochayoo, Kittikorn Wangriatisak et autres

[This corrects the article DOI: 10.1371/journal.pone.0276335.].

Atypical memory B cells from natural malaria infection produced broadly neutralizing antibodies against Plasmodium vivax variants

Piyawan Kochayoo, Saya Moriyama, Ryutaro Kotaki, Pongsakorn Thawornpan et autres

Expansion of atypical memory B cells (aMBCs) was demonstrated in malaria-exposed individuals. To date, the generation of P. vivax-specific aMBCs and their function in protective humoral immune responses is unknown. Here, P. vivax Duffy Binding Protein II (PvDBPII) probes were generated to …

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Polarization toward Tfh2 cell involved in development of MBC and antibody responses against Plasmodium vivax infection

Pongsakorn Thawornpan, Zulfa Zahra Salsabila, Piyawan Kochayoo, Tipanan Khunsri et autres

BACKGROUND: Plasmodium vivax is the dominant Plasmodium spp. causing malaria throughout tropical and sub-tropical countries. Humoral immunity is induced during P. vivax infection. However, data on longevity of antibody and memory B cell (MBC) responses is lacking. Follicular helper T cells (Tfh) …

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Development and longevity of naturally acquired antibody and memory B cell responses against Plasmodium vivax infection

Pongsakorn Thawornpan, Piyawan Kochayoo, Zulfa Zahra Salsabila, Patchanee Chootong

Plasmodium vivax malaria causes significant public health problems in endemic regions. Considering the rapid spread of drug-resistant parasite strains and the development of hypnozoites in the liver with potential for relapse, development of a safe and effective vaccine for preventing, controlling, and …

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Activation of circulating TFH17 cells associated with activated naive and double negative 2 B cell expansion, and disease activity in systemic lupus erythematosus patients

Tipanan Khunsri, Pongsakorn Thawornpan, Pachara Tianpothong, Thanitta Suangtamai et autres

Abstract Background Systemic lupus erythematosus (SLE) is the quintessential autoimmune disease, as it is characterized by hyperactivity of CD4+ T cells and subsequently drives lupus pathology. Follicular helper T (TFH) cells play an important role in B cell maturation and antibody production. …

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Diagonal Chromatography for the Isolation of O -Linked β-N-acetyl-D-Glucosaminylated ( O -GlcNAcylated) Peptides in HeLa Cell Extracts

Pongsakorn Thawornpan, Churat Weeraphan, Supinya Thanapongpichat, Charinrat Saechan et autres

Protein O-linked-N-acetylglucosaminylation (O-GlcNAcylation) is a dynamic post-translational modification process that plays an essential role in biological activities. Growing evidence indicates that aberration of O-GlcNAcylation is associated with various diseases, e.g. diabetes, neurological diseases, and cancers. However, the mechanistic studies of O-GlcNAcylation are …

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Longitudinal analysis of antibody responses to Plasmodium vivax sporozoite antigens following natural infection

Pongsakorn Thawornpan, Justin Nicholas, Chayapat Malee, Piyawan Kochayoo et autres

BACKGROUND: P. vivax malaria is a major global health burden hindering social and economic development throughout many tropical and sub-tropical countries. Pre-erythrocytic (PE) vaccines emerge as an attractive approach for the control and elimination of malaria infection. Therefore, evaluating the magnitude, longevity …

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Naturally acquired antibodies against Plasmodium vivax pre-erythrocytic stage vaccine antigens inhibit sporozoite invasion of human hepatocytes in vitro

Francis Babila Ntumngia, Surendra Kumar Kolli, Pradeep Annamalai Subramani, Samantha J. Barnes et autres

In Plasmodium vivax, the most studied vaccine antigens are aimed at blocking merozoite invasion of erythrocytes and disease development. Very few studies have evaluated pre-erythrocytic (PE) stage antigens. The P. vivax circumsporozoite protein (CSP), is considered the leading PE vaccine candidate, but …

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Preliminary characterization of Plasmodium vivax sporozoite antigens as pre-erythrocytic vaccine candidates

Justin Nicholas, Sai Lata De, Pongsakorn Thawornpan, Awtum Brashear et autres

Plasmodium vivax pre-erythrocytic (PE) vaccine research has lagged far behind efforts to develop Plasmodium falciparum vaccines. There is a critical gap in our knowledge of PE antigen targets that can induce functionally inhibitory neutralizing antibody responses. To overcome this gap and guide …

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