Naturally acquired antibodies against Plasmodium vivax pre-erythrocytic stage vaccine antigens inhibit sporozoite invasion of human hepatocytes in vitro
Rattachement africain : us, th. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
In Plasmodium vivax, the most studied vaccine antigens are aimed at blocking merozoite invasion of erythrocytes and disease development. Very few studies have evaluated pre-erythrocytic (PE) stage antigens. The P. vivax circumsporozoite protein (CSP), is considered the leading PE vaccine candidate, but immunity to CSP is short-lived and variant specific. Thus, there is a need to identify other potential candidates to partner with CSP in a multivalent vaccine to protect against infection and disease. We hypothesize that sporozoite antigens important for host cell infection are considered potential targets. In this study, we evaluated the magnitude and quality of naturally acquired antibody responses to four P. vivax PE antigens: sporozoite surface protein 3 (SSP3), sporozoite protein essential for traversal 1 (SPECT1), cell traversal protein of ookinetes and sporozoites (CelTOS) and CSP in plasma of P. vivax infected patients from Thailand. Naturally acquired antibodies to these antigens were prevalent in the study subjects, but with significant differences in magnitude of IgG antibody responses. About 80% of study participants had antibodies to all four antigens and only 2% did not have antibodies to any of the antigens. Most importantly, these antibodies inhibited sporozoite infection of hepatocytes in vitro. Significant variations in magnitude of antigen-specific inhibitory antibody responses were observed with individual samples. The highest inhibitory responses were observed with anti-CelTOS antibodies, followed by anti-SPECT1, SSP3 and CSP antibodies respectively. These data highlight the vaccine potential of these antigens in protecting against hepatocyte infection and the need for a multi-valent pre-erythrocytic vaccine to prevent liver stage development of P. vivax sporozoites.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Naturally acquired antibodies against Plasmodium vivax pre-erythrocytic stage vaccine antigens inhibit sporozoite invasion of human hepatocytes in vitro
- Date Crossref
- 13/01/2024
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of South Florida Center for Global Health and Interdisciplinary Research pays non établi dans la noticeUniversité ou école supérieure
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Center for Global Health pays non établi dans la noticeOrganisme public
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University of South Florida St. Petersburg pays non établi dans la noticeUniversité ou école supérieure
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College of Marin pays non établi dans la noticeUniversité ou école supérieure
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National Institutes of Health pays non établi dans la noticeOrganisme public
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National Institute of Allergy and Infectious Diseases pays non établi dans la noticeStructure de recherche
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Mahidol University pays non établi dans la noticeUniversité ou école supérieure
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Morsani College of Medicine Department of Molecular Medicine pays non établi dans la noticeUniversité ou école supérieure
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Laboratory of Malaria Immunology and Vaccinology Host Pathogen Interactions and Structural Vaccinology Section pays non établi dans la noticeStructure de recherche
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Faculty of Medical Technology Department of Clinical Microbiology and Applied Technology pays non établi dans la noticeUniversité ou école supérieure
Center for Global Health and Interdisciplinary Research — University of South Florida, Center for Global Health et University of South Florida St. Petersburg, avec 7 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.