Sarah Justesen

The autocrine role of FGF21 in cultured adipocytes

Sarah Justesen, Kirsten V. Haugegaard, Jacob B. Hansen, Harald S. Hansen et autres

Exposure to cold alters glucose and lipid metabolism of white and brown adipose tissue via activation of β-adrenergic receptor (ADRB). Fibroblast growth factor 21 (FGF21) has been shown to be locally released from adipose tissue upon activation of ADRBs and FGF21 increases …

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Lipid-polymer hybrid nanoparticles (LPNs) for efficient pulmonary delivery of nucleic acids: Lessons learnt from quality-by-design based optimization, immunogenicity studies, in vitro release experiments, in vivo biodistribution and efficacy studies

Kaushik Thanki, Aneesh Thakur, Anne Marit de Groot, Antonia Geyer et autres

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Engineering of small interfering RNA-loaded lipidoid-poly( DL -lactic-co-glycolic acid) hybrid nanoparticles for highly efficient and safe gene silencing: A quality by design-based approach

Kaushik Thanki, Xianghui Zeng, Sarah Justesen, Sarah Tejlmann et autres

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Adjuvants Based on Synthetic Mycobacterial Cord Factor Analogues: Biophysical Properties of Neat Glycolipids and Nanoself-Assemblies with DDA

Rie S. Kallerup, Henrik Franzyk, Mikkel Lohmann Schiøth, Sarah Justesen et autres

Synthetic mycobacterial cord factor analogues, e.g., trehalose 6,6'-dibehenate (TDB), are highly promising adjuvants due to their strong immunopotentiating capabilities, but their biophysical properties have remained poorly characterized. Here, we report the synthesis of an array of synthetic TDB analogues varying in acyl …

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Conserved Molecular Superlattices in a Series of Homologous Synthetic Mycobacterial Cell-Wall Lipids Forming Interdigitated Bilayers

Birte Martin-Bertelsen, Anan Yaghmur, Henrik Franzyk, Sarah Justesen et autres

Synthetic analogues of the cell-wall lipid monomycoloyl glycerol (MMG) are promising as next-generation vaccine adjuvants. In the present study, the thermotropic phase behavior of an array of synthetic MMG analogues was examined by using simultaneous small- and wide-angle X-ray scattering under excess …

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Efficient Pulmonary Delivery of siRNA Using Lipid-Polymer Hybrid Nanoparticles (LPNs):Insights into Formulation, Transfection and In Vivo Biodistribution Using NIR-based Spatio-Temporal Tracking.

Kaushik Thanki, A. Geyer, Xianghui Zeng, H. Sami et autres