Nana Tan

A systematic insight into glycycoumarin as potential IL-8/topo I inhibitor from natural products collected in Taibai mountain based on the combination of in silico and bioassay

Nana Tan, Lu Jia, Z. X. Li, Shiping Zhang et autres

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Systematic analysis of natural topoisomerase I inhibitors from Forsythiae Fructus by ultrafiltration-UPLC-ESI-MS/MS, pharmacophore modelling, and molecular dynamics simulation

Tian Wang, Nana Tan, Lu Jia, Z. X. Li et autres

This study conducted a systematic analysis to explore natural DNA topoisomerase I (topo I) inhibitors from Forsythiae Fructus (FF). Crude extract of FF exhibited notable toxic and anti-proliferative effects on A549 cells. A total of 36 components were identified using bioaffinity ultrafiltration …

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Combination of bioaffinity ultrafiltration-UFLC-ESI-Q/TOF-MS/MS, in silico docking and multiple complex networks to explore antitumor mechanism of topoisomerase I inhibitors from Artemisiae Scopariae Herba

Tong Chen, Jingbo Hu, Huan Wang, Nana Tan et autres

BACKGROUND: Artemisiae Scopariae Herba (ASH) has been widely used as plant medicine in East Asia with remarkable antitumor activity. However, the underlying mechanisms have not been fully elucidated. METHODS: This study aimed to construct a multi-disciplinary approach to screen topoisomerase I (topo …

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Integrated analysis of topoisomerase I inhibitors from flavonoids of Scutellaria baicalensis Georgi using bioaffinity ultrafiltration UPLC-TripleTOF MS/MS, molecular docking and target-based multiple complex networks

Nana Tan, Jingbo Hu, Huan Wang, Tong Chen et autres

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Additional file 2 of Combination of bioaffinity ultrafiltration-UFLC-ESI-Q/TOF-MS/MS, in silico docking and multiple complex networks to explore antitumor mechanism of topoisomerase I inhibitors from Artemisiae Scopariae Herba

Tong Chen, Jingbo Hu, Huan Wang, Nana Tan et autres

Additional file 2. Collection of target proteins and pathways for topoisomerase I Inhibitors from ASH extract

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A Study on Self-mentions of Korean and Chinese Linguistics Articles

Nana Tan, Yunghee Hyun

Based on a self-built corpus, this study explores the construction of self-mentions in Korean and Chinese research articles. Finding shows that in Korean articles, non-personal terms were used far more than first personal plural pronoun, while in Chinese articles, two expressions of …

Mesenchymal stem cell therapy for ischemic stroke: Novel insight into the crosstalk with immune cells

Nana Tan, Wenqiang Xin, Min Huang, Yuling Mao

Stroke, a cerebrovascular accident, is prevalent and the second highest cause of death globally across patient populations; it is as a significant cause of morbidity and mortality. Mesenchymal stem cell (MSC) transplantation is emerging as a promising treatment for alleviating neurological deficits, …

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Pathway‐based protein–protein association network to explore mechanism of α ‐glucosidase inhibitors from Scutellaria baicalensis Georgi against type 2 diabetes

Le Wang, Wenbo Diwu, Nana Tan, Huan Wang et autres

Abstract Natural products have been widely used in the treatment of type 2 diabetes (T2D). However, their mechanisms are often obscured due to multi‐components and multi‐targets. The authors constructed a pathway‐based protein–protein association (PPA) network for target proteins of 13 α‐glucosidase inhibitors …

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Antimicrobial activity and biosynthetic potential of cultivable actinomycetes associated with Lichen symbiosis from Qinghai-Tibet Plateau

Yueyu Hei, Hongli Zhang, Nana Tan, Yuhan Zhou et autres

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A systematic analysis of natural α-glucosidase inhibitors from flavonoids of Radix scutellariae using ultrafiltration UPLC-TripleTOF-MS/MS and network pharmacology

Le Wang, Nana Tan, Huan Wang, HU Jing-bo et autres

Abstract Background Flavonoids from plant medicines are supposed to be viable alternatives for the treatment of type 2 diabetes (T2D) as less toxicity and side effects.Radix scutellariae(RS) is a widely used traditional medicine in Asia. It has shown great potential in the …

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The Linguistic Landscape of Korean Town Community in Yiwu

Nana Tan

本文以语言景观的研究方法为基础，实地调查了义乌市韩人社区的语言标牌。研究发现，该社区的语言标牌多为私人标牌，官方标牌数量少，仅有三例；标牌上出现了汉、韩、英三种语言，汉语标牌占据主导地位，韩语标牌紧随其后。本研究利用语言景观构建原则中的权力关系、集体认同、突出自我原则，同时结合语言选择理论阐述了各种语言模式出现的原因。此外，韩人社区语言标牌在翻译、书写方面存在不规范现象，在语言服务管理方面存在一定缺陷，应当对这些问题加以改进，进一步提升城市形象.

Additional file 5 of A systematic analysis of natural α-glucosidase inhibitors from flavonoids of Radix scutellariae using ultrafiltration UPLC-TripleTOF-MS/MS and network pharmacology

Le Wang, Nana Tan, Huan Wang, Jingbo Hu et autres

Additional file 5. Degree values of CTP network, node strength and centrality indices of PPI network.