Martina Spaziante

Dengue Seroprevalence Among Blood Donors in the Lazio Region (Italy): Is There an Iceberg Beneath the Surface?

Martina Spaziante, Luigi Rosa, Francesca Colavita, Ilaria Mussetto et autres

During 2023, dengue virus (DENV) autochthonous circulation was detected in Lazio, Italy. To investigate the magnitude of the phenomenon, anti-DENV serological status of blood donors residing in previously affected Rome municipalities was evaluated. Between December 2024 and April 2025, blood donors consecutively …

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End-of-outbreak determination under seasonal transmission

William S. Hart, Cathal Mills, Mattia Manica, Francesco Menegale et autres

Abstract At the apparent end of an infectious disease outbreak, policymakers must decide when to relax interventions, balancing epidemiological safety and economic efficiency. Here, we extend a renewal equation framework for estimating the risk of additional cases to scenarios with seasonal transmission, …

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Monotherapy vs. combination therapy for Enterococcus faecalis bacteraemia: a target trial emulation

M. Bartoletti, Elena Rosselli Del Turco, Linda Bussini, M. Kingsly Paul et autres

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Clinical utility of the DENOVA score for predicting infective endocarditis in Enterococcus faecalis bacteraemia: external validation with decision curve analysis

Benedetta Varisco, Daniele Piovani, Elena Rosselli Del Turco, Linda Bussini et autres

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Legionnaires’ disease on the rise: moving from the COVID-19 pandemic towards the 2025 Jubilee in Rome. Data from the regional surveillance system of Lazio Region, Italy (2015-2024)

Martina Spaziante, Maurizio D’Amato, Sara Leone, Gabriella De Carli et autres

Abstract Legionnaires’ disease (LD) is an atypical pneumonia sustained by Legionella bacteria. The epidemiological LD scenario in the urban area of Rome (Italy) is unique, moving from facing the COVID-19 pandemic, first capital city in Europe, to the preparation of the 2025 …

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Dengue Virus Dynamic and Persistence in Body Fluids of Infected Patients in Italy, 2018–2023

Giulia Matusali, Mattia Manica, Alessandra D’Abramo, Fabrizio Carletti et autres

Dengue, a mosquito-borne disease caused by the dengue virus (DENV), is constantly expanding worldwide. We investigated the presence and persistence of DENV RNA in the bloodstream and other body fluids to describe the viral kinetics in the human host. We longitudinally collected …

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Post-COVID-19 resurgence of scabies’ cases in the Lazio Region, Italy: a new emerging public health threat?

Martina Spaziante, Alessandro Agresta, Maurizio D’Amato, Gabriella De Carli et autres

Scabies represents a global health issue and in 2017 was added to the World Health Organization's list of neglected tropical diseases. In European and Middle Eastern countries, cases are sporadic while recent surveillance data have pointed out an increasing incidence among vulnerable …

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Interrupted time series analysis to evaluate the impact of COVID-19-pandemic on the incidence of notifiable infectious diseases in the Lazio region, Italy

Martina Spaziante, Sara Leone, Maurizio D’Amato, Gabriella De Carli et autres

BACKGROUND: The coronavirus disease 2019 (COVID-19) emergency has represented a profound upheaval in the dynamics of infectious diseases transmission worldwide. This phenomenon has been at least in part driven by the introduction of non-pharmaceutical interventions (NPIs), implemented to counteract viral transmission. Our …

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Interrupted time series analysis to evaluate the impact of COVID-19-pandemic on the incidence of notifiable infectious diseases in the Lazio region, Italy

Martina Spaziante, Sara Leone, Maurizio D’Amato, Gabriella De Carli et autres

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Genetic and structural characterization of dengue virus involved in the 2023 autochthonous outbreaks in central Italy

Fabrizio Carletti, Gabriella De Carli, Pietro Giorgio Spezia, Cesare Ernesto Maria Gruber et autres

Dengue virus (DENV) has been expanding its range to temperate areas that are not usually affected, where the spread of vectors has been facilitated by global trade and climate change. In Europe, there have been many cases of DENV imported from other …

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Molecular Genotyping of Circulating Enterovirus in the Lazio Region from 2012 to 2023

Martina Rueca, Francesco Vairo, Martina Spaziante, Lavinia Fabeni et autres

Enteroviruses (EVs) are ubiquitous viruses that circulate worldwide, causing sporadic or epidemic infections, typically during the summer and fall. They cause a broad spectrum of illnesses, ranging from an unspecified febrile clinical presentation to a severe illness. EVs are recognized to be …

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Genetic and structural characterization of dengue virus involved in the 2023 autochthonous outbreaks in central Italy

Fabrizio Carletti, Gabriella De Carli, Pietro Giorgio Spezia, Cesare Ernesto Maria Gruber et autres

Dengue virus (DENV) has been expanding its range to temperate areas that are not usually affected, where the spread of vectors has been facilitated by global trade and climate change. In Europe, there have been many cases of DENV imported from other …