Marwa E. Abdelmageed

Fasudil Attenuates Concanavalin A-Induced Autoimmune Hepatitis and Is Associated with Suppression of RhoA/ROCK and TLR4/NF-κB Signaling and Modulation of Immune Responses

Reem A. Alzoubi, Ahmed Awad, Marwa E. Abdelmageed

Background/Objectives: Autoimmune hepatitis (AIH) is a liver injury characterized by the dysregulation of immune responses. Current options for AIH have limitations that highlight the urgent need to investigate alternative or adjunct therapeutic strategies for its management. We aimed to explore the protective …

Égypte (code pays fourni par la source)

Lobenzarit Attenuates DSS-Induced Colitis by Reprogramming Immune Microenvironment and Mitochondrial Homeostasis

Ali Khaled, Manar A. Nader, Marwa E. Abdelmageed

Background: The incidence of inflammatory bowel disease (IBD) is growing in the population. At present, the etiology of inflammatory bowel disease remains unclear, and there is no effective and low-toxic therapeutic drug. This study aimed to investigate the role of Lobenzarit (Lbz) …

Égypte, iq (code pays fourni par la source)

Correction: Empagliflozin attenuates dexamethasone-induced non-alcoholic steatohepatitis by regulation of ferroptosis, inflammation and autophagy

Naif S. Alharbi, Marwa E. Abdelmageed, Manar A. Nader, Marwa S. Serrya

[This corrects the article DOI: 10.3389/fphar.2026.1741926.].

Égypte (code pays fourni par la source)

Ambrisentan Exhibits Hepatoprotective Effects Against NASH-Associated Hepatic Injury in Dexamethasone-Treated Rats Through Regulation of Inflammation, Ferroptosis and Autophagy

Naif S. Alharbi, Manar A. Nader, Marwa S. Serrya, Marwa E. Abdelmageed

Background/Objectives: Non-alcoholic steatohepatitis (NASH) represents a worldwide health challenge with limited currently available effective treatment. The present analysis was designed to examine possible therapeutic advances of Ambrisentan (AMB) targeting multiple features of hepatic damage in dexamethasone (DEXA)-provoked nonalcoholic steatohepatitis (NASH) in rats. …

Égypte, sa (code pays fourni par la source)

Secukinumab Mitigates Cisplatin-Induced Nephrotoxicity and Enhances Cisplatin Cytotoxicity in MCF-7 Cells via IL-17A/NF-κB Axis Modulation

Faiz N. Alenezi, Marwa S. Zaghloul, Manar A. Nader, Marwa E. Abdelmageed

OBJECTIVE: The existing work was designed to appraise whether Secukinumab diminishes acute kidney injury in a Cisplatin- induced rat model and to explore the potential underlying mechanisms for this protective effect. METHODS: In vivo study, rats were distributed haphazardly into five sets …

Égypte (code pays fourni par la source)

Vonoprazan as an adjuvant to cisplatin: enhancing antitumor efficacy while mitigating nephrotoxicity and gastrointestinal adverse effects

Faiz N. Alenezi, Marwa E. Abdelmageed, Manar A. Nader, Marwa S. Zaghloul

Background/Objective Cisplatin is a popular platinum-containing chemotherapeutic agent that has been used clinically since the 1970s to manage a wide range of hematologic and solid tumors. However, its therapeutic purpose is restricted by significant dose-related toxicities, particularly nephrotoxicity and gastrointestinal damage. Therefore, …

Égypte (code pays fourni par la source)

Correction: Empagliflozin attenuates dexamethasone-induced non-alcoholic steatohepatitis by regulation of ferroptosis, inflammation and autophagy

Naif S. Alharbi, Marwa E. Abdelmageed, Manar A. Nader, Marwa S. Serrya

[This corrects the article DOI: 10.3389/fphar.2026.1741926.].

Égypte (code pays fourni par la source)

Empagliflozin attenuates dexamethasone-induced non-alcoholic steatohepatitis by regulation of ferroptosis, inflammation and autophagy

Naif S. Alharbi, Marwa E. Abdelmageed, Manar A. Nader, Marwa S. Serrya

Purpose: rats. Methods: NASH was induced by daily injection of DEXA (8 mg/kg/day, i.p.) from day 8-13. EMPA (10 and 30 mg/kg) was administered orally for 13 days from day 1-13. on day 14, serum and liver tissue were obtained and assessed …

Égypte (code pays fourni par la source)

Ameliorative effect of Tiron against paraquat-induced cerebral and pulmonary injury in rats: involvement of ferroptosis, TLR4/NF-κB and Nrf2/HO-1 signaling pathways

Nourhane M. Elemam, Manar A. Nader, Marwa E. Abdelmageed

Paraquat (PQ) is a herbicide which is used indiscriminately specially in developing countries. The objective of our study is to evaluate the toxicity of PQ on cerebral and pulmonary tissues and the efficacy of Tiron in attenuating such toxicity through focusing in …

Égypte (code pays fourni par la source)

Pirfenidone ameliorates dexamethasone-induced steatohepatitis and vascular resistance in rats

Abdullah Q. Alsaedi, Manar A. Nader, Dalia H. El-Kashef, Marwa E. Abdelmageed

Égypte (code pays fourni par la source)

A pragmatic approach of crosslinked chitosan /polyvinyl alcohol/ alogliptin nanofibrous scaffolds for tackling streptozotocin-induced rat diabetes

Ghada Ahmed El-Emam, Amira Motawea, Marwa E. Abdelmageed, Yousra M. El‐Far et autres

Égypte (code pays fourni par la source)

Ambrisentan ameliorates methotrexate-induced pulmonary injury in rats: involvement of ET-1/ETA, NF-κB, and MMP-9/TIMP-1 pathways

Dina E. Al-Wakeel, Marwa E. Abdelmageed, Mirhan N. Makled, Manar A. Nader

Égypte (code pays fourni par la source)