Yousra M. El‐Far

A pragmatic approach of crosslinked chitosan /polyvinyl alcohol/ alogliptin nanofibrous scaffolds for tackling streptozotocin-induced rat diabetes

Ghada Ahmed El-Emam, Amira Motawea, Marwa E. Abdelmageed, Yousra M. El‐Far et autres

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Ferulic acid lipid nano capsules versus its native form in alleviating diabetic nephropathy induced in rats through TGF-β1/Hippo pathway crosstalk modulation

Mona H. Zohny, Yousra M. El‐Far, Mohamed Fawzi Kabil, Sahar Elsayed El-Swefy et autres

Diabetic nephropathy is one of the most common leading causes of end-stage renal disease with multifactorial pathophysiological mechanisms. TGF-β1 and Hippo pathway have been reported to have significant role in different kidney diseases. In addition, ferulic acid (FA) has been proposed to …

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Citronellal Alleviates Insulin Resistance in High‐Fat Diet/Streptozocin Model: Role of Asprosin/Olfactory Receptor Axis

Aya I. Abdelaziz, Yousra M. El‐Far, Noha Abdel‐Rahman

Ectopic olfactory receptors are expressed in nonolfactory tissues and perform diverse roles including regulation of glucose homeostasis. We explored the effect of citronellal treatment on olfactory receptor 4M1 subtype (OR4M1) signaling in insulin resistance and Type II diabetes in rats. We aimed …

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Tazemetostat decreases β-catenin and CD13 protein expression in HEPG-2 and Hepatitis B virus-transfected HEPG-2 with decreased cell viability

Mohamed N. Amin, Yousra M. El‐Far, Mohammed El‐Mowafy, Abdelaziz Elgaml

Hepatocellular carcinoma (HCC) is one of the global health concerns. Hepatitis B virus (HBV) is one of the major causes of HCC. Poor clinical outcome of HCC patients is attributed to a small population of cancer cells known as cancer stem cells …

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Rapamycin Improves Adipose-Derived Mesenchymal Stem Cells (ADMSCs) Renoprotective Effect against Cisplatin-Induced Acute Nephrotoxicity in Rats by Inhibiting the mTOR/AKT Signaling Pathway

Amira Awadalla, Abdelaziz M. Hussein, Yousra M. El‐Far, Fardous F. El‐Senduny et autres

Objective: Because the poor survival of transplanted cells in a hostile microenvironment limits stem cell therapy, in the current study, we investigated the effect of rapamycin (Rapa)-preactivated autophagy on the survival and homing of transplanted adipose mesenchymal stem cells (ADMSCs) in a …

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Chemopreventive and hepatoprotective effects of genistein via inhibition of oxidative stress and the versican/PDGF/PKC signaling pathway in experimentally induced hepatocellular carcinoma in rats by thioacetamide

Yousra M. El‐Far, Ahmed E. Khodir, Ziad A. Emarah, Mohamed Ayman Ebrahim et autres

OBJECTIVE: Genistein is a recognized isoflavone present in soybeans with antioxidant, anti-inflammatory, antiangiogenic and antitumor activities. This study aimed to test ability of genistein in modulating versican/platelet derived growth factor (PDGF) axis in HCC. METHODS: HCC was experimentally induced in male Sprague-Dawley …

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The prophylactic and therapeutic effects of the phytochemical combination breast safeguard on Ehrlich cell progression

Heba Allah Alwasify, Yousra M. El‐Far, Mohamed Elsaid Abdraboh

2 million new cases in 2019. Phytochemicals have been used in traditional medicine for centuries, however, they recently gained attention in cancer research due to their potent antioxidant, anti-inflammatory, and immunomodulatory effects. This study aimed to elucidate the prophylactic and/or therapeutic effect …

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Novel doxorubicin / folate-targeted trans-ferulic acid-loaded PLGA nanoparticles combination: In-vivo superiority over standard chemotherapeutic regimen for breast cancer treatment

Sahar A Helmy, Saif El-Mofty, Amal M. El Gayar, Ibrahim mohammed El-sherbiny et autres

AIM: Doxorubicin/Cyclophosphamide (AC) is one of the standard adjuvant anthracycline-containing regimens that is still in use for breast cancer treatment. Cancer cell resistance and AC-induced side effects make treatment suboptimal and worsen patients' quality of life. This study aimed to improve trans-ferulic …

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Pevonedistat attenuates cisplatin‐induced nephrotoxicity in mice by downregulating the release of inflammatory mediators

Yousra M. El‐Far, Mohamed El‐Mesery

Pevonedistat (MLN4924) is a specific NEDD8-activating enzyme inhibitor that inactivates cullin-RING ligases involved in ubiquitylation and turnover of different signaling molecules. In the current study, we evaluated the effect of pevonedistat on cisplatin (CIS)-induced nephrotoxicity in mice. Serum creatinine and urea levels …

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Effect of zinc oxide nanoparticles and ferulic acid on renal ischemia/reperfusion injury: possible underlying mechanisms

Amira Awadalla, Abdelaziz M. Hussein, Yousra M. El‐Far, Nashwa M. Barakat et autres

OBJECTIVES: The present study examined the effects of ferulic acid (FA) and Zinc oxide nanoparticles (ZnO-NPs) and a combination of both on renal ischemia/reperfusion injury (IRI) in rats and their possible underlying mechanisms. METHODS: two-hundreds male Sprague Dawley rats were randomly allocated …

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Radio-sensitizing effect of a cocktail of phytochemicals on HepG2 cell proliferation, motility and survival

Mohamed Elsaid Abdraboh, Zaidoon Shaker Essa, Abdelrazek B. Abdelrazzak, Yousra M. El‐Far et autres

Radio-resistance is a major hurdle challenging oncologist worldwide. Despite their anti-cancer characteristics, the implication of phytochemicals in clinical trials is still limited. This study is designed to evaluate the anticancer characteristics and radio-sensitizing effect of a cocktail of seven phytochemicals on HepG2 …

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Fucoidan Ameliorates Hepatocellular Carcinoma Induced in Rats: Effect on miR143 and Inflammation

Yousra M. El‐Far, Ahmed E. Khodir, Ziad A. Emarah, Mohamed Ayman Ebrahim et autres

Fucoidan is sulfated polysaccharide of brown seaweed. It offers various pharmacological actions like anti-inflammatory, anti-bacterial and anti-tumor activities. Therefore, we aimed to investigate the effect of targeting microRNA-143 and inflammatory pathway by Fucoidan on experimentally induced hepatocellular carcinoma (HCC) in rats. HCC …

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