Monica Venere

Cell death pathways and chemotherapy in brain tumors

Upasana Sahu, Monica Venere, Balveen Kaur

H2AX phosphorylation driven by the SET-PP2A axis maintains glioma stem cell properties

Chunhua Han, Na Li, Ananya Tina Banerjee, Linzhou Wang et autres

Glioblastoma harbors a subpopulation of glioma stem cells (GSCs) that drive tumor relapse and invasion. Although GSC properties are known to be regulated by key transcription factors and chromatin remodeling, the mechanisms governing stemness-associated gene expression and the role of histone proteins …

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A Human Neuronal Co-Culture System Reveals Early Tumor-Neuron Communication and Targetable Pathways in Glioblastoma

Ouada Nebie, Niyi Adelakun, Liwen Zhang, Luke Kollin et autres

Glioblastoma (GB) co-opts neuronal circuits to drive tumor progression, yet the earliest neuronal responses that may shape recurrence remain poorly defined. We developed a human iPSC-derived neuronal co-culture model that captures acute communication between neurons and glioblastoma from diverse sources, including serum-adapted …

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Epitranscriptomic analysis reveals clinical and molecular signatures in glioblastoma

G Fernandes, Wesley Wang, Saman Seyed Ahmadian, Daniel Mark Jones et autres

This study characterizes the glioblastoma (GB) epitranscriptomic landscape in patient who evolve to progressive disease (PD) or pseudo-progressive disease (psPD). Novel differences in N6-Methyladenosine (m6A) RNA methylation patterns between these groups are identified in the first biopsy. Retrospective data of patients that …

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A Microfluidic Blood Brain Barrier Model to Study the Influence of Glioblastoma Tumor Cells on BBB Function

Thomas J. DePalma, Marco A. Rodríguez, Luke Kollin, Kennedy Hughes et autres

The blood brain barrier (BBB) plays an essential role in regulating brain function by controlling the transport of nutrients and preventing toxins from moving from the rest of the body's circulation into the brain. Because it is more selective than most other …

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Profiling Magnetically Sorted Glioblastoma Cells Using Extracellular Matrix-Mimicking Integrin-Targeting Probes

Emerie Stagner, Blair L. Rist, Jason Scharenberg, Isabel M Garcı́a et autres

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List of contributors

Rolla Abu-Arja, Jenny K. Adamski, Manish Kumar Aghi, Manmeet Singh Ahluwalia et autres

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Identification of Triapine as a Novel Radiosensitizer in Glioblastoma

Tiantian Cui, Sergio Corrales-Guerrero, Verónica Castro-Aceituno, Sindhu Nair et autres

PP2A B55α inhibits epithelial-mesenchymal transition via regulation of Slug expression in non-small cell lung cancer

Deepika Singh, Zhaojun Qiu, Jonathan M. Spehar, Pengyan Fa et autres

PP2A B55α, encoded by PPP2R2A, acts as a regulatory subunit of the serine/threonine phosphatase PP2A. Despite a frequent loss of heterozygosity of PPP2R2A in cases of non-small cell lung cancer (NSCLC), research on PP2A B55α′s functions remains limited and controversial. To investigate …

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EPEN-04. OVERWHELMING ZFTA-RELA NUCLEAR LOCALIZATION AS A THERAPEUTIC STRATEGY AGAINST EPENDYMOMA

Amir Arabzade, Siri Manasa Ippagunta, Alisha Kardian, Erik Emanus et autres

Abstract BACKGROUND Pediatric ependymoma is a malignant brain tumor without targeted therapies. The 10-year survival is close to 50%, as this relentless tumor often relapses years following initial diagnosis. Over two thirds of supratentorial ependymomas harbor a gene fusion between ZFTA and …

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2100: HMGB2 KD shortens G2/M, reduces cell, proliferation, and radio-sensitizes TP53wt and mutant GBM cells

Aline Paixão Becker, Valesio Becker, Ebin Sebastian, Saikh Jaharul Haque et autres

Burnout and career satisfaction in young neuro-oncology investigators: Results of the Society for Neuro-Oncology Young Investigator Survey

Gilbert Youssef, Alvina A. Acquaye-Mallory, Elizabeth M Vera, Milan G. Chheda et autres

Background: Burnout is a syndrome characterized by emotional exhaustion, depersonalization, and a reduced sense of accomplishment, which commonly arises from chronic workplace stress in the medical field. Given the higher risk of burnout in younger age groups reported in some studies, the …

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