Maximiliano Arce

RNA-seq studies in dabrafenib treated endothelial cells

Maximiliano Arce, Sun Ying, Peetra Ulrica Magnusson

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RNA-seq studies in dabrafenib treated endothelial cells

Maximiliano Arce, Sun Ying, Peetra Ulrica Magnusson

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Protocol for generation of endothelial cells from human-derived iPSCs and integration into mouse brain explants

Iza Erzar, Nora Noll, Roberta Lugano, Anna Dimberg et autres

The rapid and reliable generation of endothelial cells from induced pluripotent stem cells (iPSCs) is a keystone for biomedical research and regenerative medicine. Here, we present a protocol for human iPSC genetic engineering, ETS variant 2 (ETV2)-mediated endothelial differentiation, and subsequent injection …

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KRIT1 heterozygous mutations are sufficient to induce a pathological phenotype in patient-derived iPSC models of cerebral cavernous malformation

Maximiliano Arce, Iza Erzar, Fan Yang, Favour Chinyere Onyeogaziri et autres

Cerebral cavernous malformation (CCM) is a neurovascular disease distinguished by clusters of leaky, mulberry-like blood vessels. KRIT1 bi-allelic loss-of-function mutations in endothelial cells are known to trigger brain cavernomas; however, human preclinical models are needed to unveil the importance of germline KRIT1 …

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Pharmacological blocking of neutrophil extracellular traps attenuates immunothrombosis and neuroinflammation in cerebral cavernous malformation

Favour Chinyere Onyeogaziri, Ross Smith, Maximiliano Arce, Hua Huang et autres

Cerebral cavernous malformation (CCM) is a neurovascular disease with symptoms such as strokes, hemorrhages and neurological deficits. With surgery being the only treatment strategy, understanding the molecular mechanisms of CCM is crucial in finding alternative therapeutic options for CCM. Neutrophil extracellular traps …

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BMI1 Inhibition Improves Lesion Burden in Cerebral Cavernous Malformations

Mariaelena Valentino, Matteo Malinverno, Claudio Maderna, Van-Cuong Pham et autres

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Coronary Artery Disease Risk Variant Dampens the Expression of CALCRL by Reducing HSF Binding to Shear Stress Responsive Enhancer in Endothelial Cells In Vitro

Ilakya Selvarajan, Miika Kiema, Ru‐Ting Huang, Jin Li et autres

BACKGROUND: CALCRL (calcitonin receptor-like) protein is an important mediator of the endothelial fluid shear stress response, which is associated with the genetic risk of coronary artery disease. In this study, we functionally characterized the noncoding regulatory elements carrying coronary artery disease that …

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Dysregulated Hemostasis and Immunothrombosis in Cerebral Cavernous Malformations

Maria Ascención Globisch, Favour Chinyere Onyeogaziri, Ross Smith, Maximiliano Arce et autres

Cerebral cavernous malformation (CCM) is a neurovascular disease that affects 0.5% of the general population. For a long time, CCM research focused on genetic mutations, endothelial junctions and proliferation, but recently, transcriptome and proteome studies have revealed that the hemostatic system and …

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Slow-Closing Clip for the Treatment of Nonsaccular Vertebrobasilar Aneurysms: A Retrospective Case Series

Behnam Rezai Jahromi, Reza Dashti, Oriela Rustemi, João Silva et autres

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Immunothrombosis and vascular heterogeneity in cerebral cavernous malformation

Maria Ascención Globisch, Favour Chinyere Onyeogaziri, Suvi Jauhiainen, Anthony C. Y. Yau et autres

Cerebral cavernous malformation (CCM) is a neurovascular disease that results in various neurological symptoms. Thrombi have been reported in surgically resected CCM patient biopsies, but the molecular signatures of these thrombi remain elusive. Here, we investigated the kinetics of thrombi formation in …

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Propranolol Reduces the Development of Lesions and Rescues Barrier Function in Cerebral Cavernous Malformations

Joppe Oldenburg, Matteo Malinverno, Maria Ascención Globisch, Claudio Maderna et autres

Background and Purpose: Cerebral cavernous malformations (CCM) present as mulberry-like malformations of the microvasculature of the central nervous system. Current medical treatment of CCM lesions is limited to surgical removal of the vascular malformations. It is, therefore, important to identify therapeutic drug …

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Coagulation Factor Xa Promotes Solid Tumor Growth, Experimental Metastasis and Endothelial Cell Activation

Maximiliano Arce, Mauricio P. Pinto, Macarena Galleguillos, Catalina Muñoz et autres

Hypercoagulable state is linked to cancer progression; however, the precise role of the coagulation cascade is poorly described. Herein, we examined the contribution of a hypercoagulative state through the administration of intravenous Coagulation Factor Xa (FXa), on the growth of solid human …

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