Timur I. Khaibullin

Early diagnosis of multiple sclerosis in the context of the 2024 McDonald criteria: from clinically and radiologically isolated syndromes to biological verification of the disease

Farit A Khabirov, Evgenii V. Granatov, Timur I. Khaibullin, A. Ya. Dykhanov

This article examines the evolution of diagnostic criteria for multiple sclerosis (MS), with a focus on the 2024 revision of the McDonald criteria as a milestone in the diagnosis of the disease. A comprehensive analysis of changes in MS diagnostic approaches is …

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Possible Reasons for the Suboptimal Response of the Cladribine Course in Daily Practice: An Independent Analysis of Data from 12 Russian Clinics and the Results of Post-Registration Studies in Other Countries

Alexey Boyко, Valentina Mikhailovna Alifirova, D. V. Pashkovskaya, Ekaterina I. Kuchina et autres

Objectives: The purpose of this study was to analyze the effect of daily intake of cladribine tablets on the course of multiple sclerosis (MS) while monitoring for 1–4 years during and after the course in several neurological clinics from different regions of …

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Results of medical and social research and assessment of quality of life in myasthenia gravis

Ilya V. Vlasov, Yu. A. Merkulov, Valentina Mikhailovna Alifirova, M V Abroskina et autres

Myasthenia gravis (MG) is one of the most common autoimmune diseases of the nervous system. Medical and social analysis of the patient population structure and assessment of their quality of life (QoL) as one of the criteria for the effectiveness of treatment …

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Allogeneic Treg-derived artificial vesicles: A promising therapeutic modality for multiple sclerosis

Irina Ganeeva, Elvina Gilyazova, Artur Khannanov, Mariia Eugenievna Nektorova et autres

Introduction: Tregs, which normally suppress immune responses, exhibit impaired function in MS. Treg-derived extracellular vesicles (EVs) carry immunoregulatory proteins and miRNAs that modulate T-cell activity. However, EVs from MS patients show reduced suppressive capacity, suggesting their dysfunction contributes to MS pathogenesis. This …

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Features of the clinical course of multiple sclerosis as a factor in persistent disability

Farit A Khabirov, Damir Ildarovich Marapov, Timur I. Khaibullin

OBJECTIVE: To study the effect of clinical factors on the disability of multiple sclerosis (MS) patients based on the data from the Republic of Tatarstan. MATERIALS AND METHODS: The study was based on the patient data from the regional register of patients …

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Resveratrol and Its Metabolite as Potential Allosteric Regulators of Monoamine Oxidase A Activity in the Brain and Liver Under Chronic Predator Stress

Jurica Novak, Olga B. Tseilikman, Vladislav A. Shatilov, Maxim S. Zhukov et autres

Background: Resveratrol has been shown to modulate stress-related anxiety by reducing brain monoamine oxidase A (MAO-A) activity. However, the molecular mechanism underlying this neurochemical effect remains unknown. In this study, we employed in silico approaches to investigate the binding affinity of resveratrol …

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DISABILITY FACTORS IN MULTIPLE SCLEROSIS PATIENTS

Damir Ildarovich Marapov, E. R. Sabirova, Timur I. Khaibullin

This study is devoted to the study of the level of disability and factors influencing the disability of patients with multiple sclerosis (MS). The dependence of the incidence of disability in MS patients on various socio-hygienic and biological factors was assessed. The …

Methods of diagnostics and correction of various dissomnic disorders

S. E. Belov, Farit A Khabirov, Timur I. Khaibullin, G. M. SHARAFUTDINOVA

The article presents data on diagnostic and correction methods of various dissomnic disorders. Sleep disorders represent a heterogeneous group of pathologies, their development mechanism being actively studied. Accurate diagnosis of sleep disorders is based on a thorough history collection, physical examination, and …

Experience with the use of cladribine tablets in real-life clinical practice: independent analysis of data from 12 Russian clinical centres

Valentina Mikhailovna Alifirova, D. V. Pashkovskaya, Ekaterina I. Kuchina, Stella A. Sivertseva et autres

Multiple sclerosis (MS) is an autoimmune-inflammatory and neurodegenerative disease of the central nervous system. The article analyses the ability of cladribine, which due to its selective lymphotoxic effect on activated cells and central effect on immunomodulation in brain tissue underwent successful clinical …

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Analysis of the experience with once-weekly intramuscular administration of interferon beta-1a in the Russian population of patients with relapsing-remitting multiple sclerosis

Farit A Khabirov, Evgenii V. Granatov, A. Ya. Dykhanov, Timur I. Khaibullin

SinnoVex is a drug from the group of bioanalogues of interferon beta-1a for intramuscular administration, which has moderate efficacy in reducing clinical exacerbations of multiple sclerosis (MS), which is most pronounced in the initial treatment of relapsing-remitting MS (RRMS) with low or …

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Dissomnic disorders in multiple sclerosis

S. E. Belov, Farit A Khabirov, Timur I. Khaibullin, G. M. SHARAFUTDINOVA

The article presents and summarizes the literature data on sleep disorders in patients with multiple sclerosis (MS). Sleep disorders are four times more common in patients with multiple sclerosis than in the general population. However, in some cases it can be difficult …

Assessment of risk factors for mortality in multiple sclerosis

G. M. SHARAFUTDINOVA, Farit A Khabirov, Timur I. Khaibullin, Д. И. Марапов et autres

The article shows the results of studying the factors influencing mortality in multiple sclerosis. The following risk factors for death were established: male gender, rural population, primary progressive and secondary progressive type of multiple sclerosis, high initial EDSS indicators at the disease …