Rahul Gopalam

Targeting LIPA with ERX-41 Induces ER Stress and Inhibits Tumor Progression in Inflammatory Breast Cancer

Zenaida Fuentes, Gaurav Sharma, Bianca A. Romo, Rahul Gopalam et autres

Approximately 2–4% of all breast cancer cases are inflammatory breast cancer (IBC), an extremely rare and severe subtype of the disease. Current therapies, including chemotherapy, surgery, and radiotherapy, remain insufficient, underscoring the need for novel therapeutic approaches. IBC exhibits elevated basal endoplasmic …

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Therapeutic optimization of LIPA targeting to induce endoplasmic reticulum stress and cell death in ovarian cancer

Suryavathi Viswanadhapalli, Tae-Kyung Lee, Scott Terry Elmore, Gaurav Sharma et autres

Ovarian cancer (OCa) remains the most lethal gynecologic malignancy in the United States, with a five-year survival rate below 20%. Elevated basal levels of endoplasmic reticulum stress (ERS) have recently emerged as a therapeutic vulnerability in OCa. We have previously shown that …

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Abstract 3756: Optimization of the LIPA targeting agent for the treatment of ovarian cancer

Suryavathi Viswanadhapalli, Taekyung Lee, Kara Kassees, Gaurav Sharma et autres

Abstract Background: Ovarian cancer (OCa) is the most lethal form of gynecologic cancer in the United States, with a five-year survival rate below 20%. Tumor resistance to chemotherapy and poor clinical outcomes are driven by intratumoral and intertumoral heterogeneity. There is a …

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Supplementary Table 1 from PELP1 Is a Novel Therapeutic Target in Hepatocellular Carcinoma

Khaled Mohamed Nassar, Xue Yang, Adriana Baker, Rahul Gopalam et autres

Supplementary Table 1. List of all the primers used for RT-qPCR.

Supplementary Figure 1 from PELP1 Is a Novel Therapeutic Target in Hepatocellular Carcinoma

Khaled Mohamed Nassar, Xue Yang, Adriana Baker, Rahul Gopalam et autres

Figure S1. Levels of PELP1 expression in 6 HCC cell lines.

Supplementary Figure 2 from PELP1 Is a Novel Therapeutic Target in Hepatocellular Carcinoma

Khaled Mohamed Nassar, Xue Yang, Adriana Baker, Rahul Gopalam et autres

Figure S2. SMIP34 treatment downregulates liver specific genes, MYC and E2F pathway targeted genes in HCC cells.

Significance of LIF/LIFR Signaling in the Progression of Obesity-Driven Triple-Negative Breast Cancer

Lois Randolph, Jaitri Joshi, Alondra L. Rodriguez Sanchez, Uday P. Pratap et autres

American women with obesity have an increased incidence of triple-negative breast cancer (TNBC). The impact of obesity conditions on the tumor microenvironment is suspected to accelerate TNBC progression; however, the specific mechanism(s) remains elusive. This study explores the hypothesis that obesity upregulates …

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Data from PELP1 Is a Novel Therapeutic Target in Hepatocellular Carcinoma

Khaled Mohamed Nassar, Xue Yang, Adriana Baker, Rahul Gopalam et autres

Abstract Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths in the United States, with a median survival period of approximately 10 months. There is an urgent need for the development of effective targeted therapies for the treatment of …

Figure 3 from PELP1 Is a Novel Therapeutic Target in Hepatocellular Carcinoma

Khaled Mohamed Nassar, Xue Yang, Adriana Baker, Rahul Gopalam et autres

Analysis of global transcriptional changes in PELP1-KD HCC cells. Volcano plot of differentially expressed genes with PELP1-KD in Hep3B cells is displayed (n = 3; A). PELP1-downregulated pathways were identified using differentially expressed gene signature (B). Gene set enrichment analysis plots show …

Figure 1 from PELP1 Is a Novel Therapeutic Target in Hepatocellular Carcinoma

Khaled Mohamed Nassar, Xue Yang, Adriana Baker, Rahul Gopalam et autres

PELP1 expression is upregulated in HCC, and high PELP1 expression is associated with poor survival of patients with HCC. Data obtained from TNMplot shows increased expression of PELP1 in patients with HCC (A). The results from TCGA-UALCAN database show that PELP1 expression …

Figure 5 from PELP1 Is a Novel Therapeutic Target in Hepatocellular Carcinoma

Khaled Mohamed Nassar, Xue Yang, Adriana Baker, Rahul Gopalam et autres

PELP1-KD or SMIP34 treatment suppresses HCC xenograft tumor growth in vivo. Hep3B–control and Hep3B–PELP1-KD model cells were injected subcutaneously into female (A, D, and G) or male SCID mice (B, E, and H). Tumor volumes were assessed at 3 to 5 days …

Supplementary Figure 1 from PELP1 Is a Novel Therapeutic Target in Hepatocellular Carcinoma

Khaled Mohamed Nassar, Xue Yang, Adriana Baker, Rahul Gopalam et autres

Figure S1. Levels of PELP1 expression in 6 HCC cell lines.