Jacques Aubry

Patients treated with vitamin K oral anticoagulants in family practice: a new approach to bleeding risk assessment. An ancillary study by the CACAO prospective general practice cohort

Yoann Gaboreau, Paul Frappé, Céline Vermorel, Alison Foote et autres

BACKGROUND: The ability of bleeding risk scores to predict major bleeding (MB) or clinically relevant nonmajor bleeding (CRNMB) remains a topic of contention, particularly in nonselected patients in family practice. In addition, the capacity to predict bleeding risk using simple variables has …

fr (code pays fourni par la source)

Oral anticoagulant safety in family practice: prognostic accuracy of Bleeding Risk Scores (from the CACAO study)

Yoann Gaboreau, Paul Frappé, Céline Vermorel, Alison Foote et autres

BACKGROUND: To assess bleeding risk of patients treated by oral anticoagulants, several scores have been constructed to assist physicians in the evaluation of the benefit risk. Most of these scores lack a strong enough level of evidence for use in family practice. …

fr (code pays fourni par la source)

Detection of the IS2404 insertion sequence and ketoreductase produced by Mycobacterium ulcerans in the aquatic Heteroptera in the health districts of Dabou and Tiassalé in Côte d’Ivoire

K.L. Konan, J. M. C. Doannio, Naga Coulibaly, Euloge Ekaza et autres

Buruli ulcer (BU) disease, caused by Mycobacterium ulcerans, is a major public health problem in Côte d'Ivoire. Until now, the mode of BU transmission was unknown, but recent studies implicate aquatic Heteroptera in the chain of transmission. This study was launched in …

Côte d’Ivoire, Cameroun, fr (code pays fourni par la source)

Liste des collaborateurs

Marie C. Béné, Christian Drouet, Sylvain Fisson, Estelle Seillès et autres

Inhibition of tumor angiogenesis by globotriaosylceramide immunotargeting

Stéphane Birklé, Ariane Desselle, Tanguy Chaumette, Marie‐Hélène Gaugler et autres

Current antiangiogenic immunotherapeutic strategies mainly focus on the blockade of circulating cytokines or receptors that are overexpressed by endothelial cells. We proposed globotriaosylceramide (Gb3) as a viable alternative target for antiangiogenic therapies. In this setting, we developed an anti-Gb3 antibody and validated …

fr, no (code pays fourni par la source)

Cell cycle arrest and apoptosis induced by O-acetyl-GD2-specific monoclonal antibody 8B6 inhibits tumor growth in vitro and in vivo

Denis Cochonneau, Mickaël Terme, Alexis Michaud, Mylène Dorvillius et autres

fr (code pays fourni par la source)

Anti-Gb3 Monoclonal Antibody Inhibits Angiogenesis and Tumor Development

Ariane Desselle, Tanguy Chaumette, Marie‐Hélène Gaugler, Denis Cochonneau et autres

Inhibiting the growth of tumor vasculature represents one of the relevant strategies against tumor progression. Between all the different pro-angiogenic molecular targets, plasma membrane glycosphingolipids have been under-investigated. In this present study, we explore the anti-angiogenic therapeutic advantage of a tumor immunotherapy …

fr (code pays fourni par la source)

Human antibody response to Lethocerus salivary antigens as a correlate of protection to Buruli ulcer

Christelle Mbondji-Wonje, P Mbondji-Ebongue, Y Kamdem-Simo, EN Tabah et autres

Mycobacterium ulcerans the causative agent of Buruli ulcer, a necrotizing skin disease, is an environmental mycobacterium thought to be transmitted from aquatic niches. It has previously been demonstrated that predatory aquatic insects could be both reservoirs and potential vectors of Mycobacterium ulcerans. …

A Monoclonal Antibody to O-Acetyl-GD2 Ganglioside and Not to GD2 Shows Potent Anti-Tumor Activity without Peripheral Nervous System Cross-Reactivity

Nidia Alvarez-Rueda, Ariane Desselle, Denis Cochonneau, Tanguy Chaumette et autres

BACKGROUND: Monoclonal antibodies (mAb) against GD2 ganglioside have been shown to be effective for the treatment of neuroblastoma. Beneficial actions are, however, associated with generalized pain due to the binding of anti- GD2 mAbs to peripheral nerve fibers followed by complement activation. …

fr (code pays fourni par la source)

Geographic Expansion of Buruli Ulcer Disease, Cameroon

Estelle Marion, Jordi Landier, P. Boisier, Laurent Marsollier et autres

mycobacteriology: a guide for

ir, Cameroun, Bénin, fr (code pays fourni par la source)

[Micronecta sp (Corixidae) and Diplonychus sp (Belostomatidae), two aquatic Hemiptera hosts and/or potential vectors of Mycobacterium ulcerans (pathogenic agent of Buruli ulcer) in Cote d'Ivoire].

J. M. C. Doannio, K.L. Konan, F N Dosso, A. Koné et autres

Buruli ulcer is currently a major public health problem in Côte d'Ivoire. It is a neglected tropical disease closely associated with aquatic environments. Aquatic insects of the Hemiptera order have been implicated in human transmission of Mycobacterium ulcerans, the pathogenic agent of …

Côte d’Ivoire (code pays fourni par la source)

Entomological investigations carried out from 2002 to 2010 into the involvement of water bugs (Heteroptera - Hemiptera) in transmission of Mycobacterium ulcerans to humans in Côte d’Ivoire (West Africa)

J. M. C. Doannio, Kouassi Konan, Nansou Dosso-Fadiga, Diakridia Fofana et autres

International audience

fr, Côte d’Ivoire (code pays fourni par la source)