Denis Cochonneau

Tetraploidy in cancer: Diagnostic and therapeutic perspectives

Aline Lessa, Romain Levergeois, Javier Muños-Garcia, Joshua Mountford et autres

Tetraploidy, defined as a cell state containing four complete sets of chromosomes, is a major event in cancer development and progression. This review first presents the mechanisms of formation of tetraploid cells that involve five main pathways: endoreduplication bypass, DNA re-replication, telomeric …

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Factor VIII restores bone parameters and modulates muscle proteo-metabolome in Factor VIII knockout male mice

Antoine Babuty, Javier Muñoz-García, Olivier D. Christophe, Laurie Fradet et autres

Abstract In addition to its role in hemostasis, Factor VIII (FVIII) has recently been shown to potentially impact angiogenesis, inflammation, osteopenia, and sarcopenia. This was explored here by studying the musculoskeletal development of FVIII knockout ( FVIII -/- ) male mice. These …

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Deciphering the interaction between osteosarcoma and mesenchymal stem cells in a 3D bone-mimetic co-culture model

Giada Bassi, Mohamed Saqawa, Lorenzo Apolloni, Silvia Díaz-Prado et autres

Osteosarcoma (OS) is a highly heterogeneous and aggressive bone malignancy whose complexity is strongly influenced by its Tumor Microenvironment (TME). Within this niche, Mesenchymal Stem Cells (MSCs) play a pivotal role in tumor progression by undergoing phenotypic and functional reprogramming under tumor-derived …

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Cultures cellulaires en trois dimensions : applications à la biologie des cancers

Camille Jubelin, Maxime Golias, Denis Cochonneau, Javier Muñoz-García et autres

Cancer is a multigenic pathology whose dynamic, evolving and heterogeneous nature has led to the development of a variety of models to study it. Traditionally, two-dimensional (2D) cell culture has been used in vitro. However, an accumulated body of data demonstrates the …

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Circulating tumour cells for the prediction of the response to radiation therapy in prostate cancer

Daria Klusa, Denis Cochonneau, Stéphane Supiot, Dominique Heymann

Circulating tumour cells (CTCs) have emerged as a promising biomarker for assessing prognosis and predicting therapeutic efficacy in various cancers, including metastatic prostate cancer. However, predicting patient response to treatment, including radiation therapy (RT), remains a significant clinical challenge. This review explores …

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Osteosarcoma development in Opg -/-mice: deciphering their origin and high metastatic dissemination capacity

Aline Lessa, Romain Levergeois, Javier Muñoz-García, Jorge William Vargas-Franco et autres

International audience

2467 Combining SBRT and durvalumab in hormone-sensitive prostate cancer with oligorecurrent metastases: a randomized phase II trial (POSTCARD GETUG P13)

Laure Hily, Maximilien Rogé, Dominique Heymann, Y. Pointreau et autres

Isolation and Characterization of Circulating Tumor Cells

Daria Klusa, Denis Cochonneau, Emilie Ollivier, Antoine Chalopin et autres

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CIRCUS: CIRCUlating tumour cells in soft tissue Sarcoma - a short report

Robin Young, Joanna E. Chowdry, Denis Cochonneau, Dominique Heymann

Aims: Circulating tumour cells (CTCs) can be detected in peripheral blood using their physical properties (increased size and less deformable than normal circulating blood cells) or using cell surface markers. The study of these CTCs should provide important insights into tumour biology, …

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Interleukin-34 orchestrates bone formation through its binding to Bone Morphogenic Proteins

Dominique Heymann, Frédéric Lézot, Javier Muñoz-García, Jorge William Vargas-Franco et autres

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Identification of MCM4 and PRKDC as new regulators of osteosarcoma cell dormancy based on 3D cell cultures

Camille Jubelin, Javier Muñoz-García, Emilie Ollivier, Denis Cochonneau et autres

Dormancy is a potential way for tumors to develop drug resistance and escape treatment. However, the mechanisms involved in cancer dormancy remain poorly understood. This is mainly because there is no in vitro culture model making it possible to spontaneously induce dormancy. …

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Technical report: liquid overlay technique allows the generation of homogeneous osteosarcoma, glioblastoma, lung and prostate adenocarcinoma spheroids that can be used for drug cytotoxicity measurements

Camille Jubelin, Javier Muñoz-García, Denis Cochonneau, Emilie Ollivier et autres

Introduction: The mechanisms involved in cancer initiation, progression, drug resistance, and disease recurrence are traditionally investigated through in vitro adherent monolayer (2D) cell models. However, solid malignant tumor growth is characterized by progression in three dimensions (3D), and an increasing amount of …

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