Yusuke Kurosawa

Double-stranded RNA impairs epithelial barrier formation by redirecting airway basal cell differentiation

Shinichi Okamoto, Shuichiro Maruoka, Kota Tsuya, Mari Hikichi et autres

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Analysis of blood homocysteine (Hcy) in bronchial asthma patients at our hospital

Yusuke Kurosawa, Shuichiro Maruoka, Yuichiro Takeshita, Masako To et autres

Background: Nitric oxide and reactive oxygen species are released in asthmatic airways, and the interaction between these substances induces oxidative and nitrative stress, which is involved in the intractability of asthma. While FeNO reflects nitrative stress in the airways, there is no …

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Establishment of IL-33 plus TSLP-induced human steroid-resistant asthma model using humanized mice and its potential application in preclinical research

Shiho Yamada, Shuichiro Maruoka, Shota Toyoshima, Yusuke Kurosawa et autres

Background: The mechanism of steroid-resistant asthma remains unclear because of the difficulty of directly analyzing the lungs of patients. We have already established a human asthma model using humanized human (h) IL-3/hGM-CSF/hIL-5 Transgenic NOG mice, which can differentiate into human immune cells …

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Novel Humanized Mouse Model for Steroid‐Resistant Asthma

Shiho Yamada, Shuichiro Maruoka, Shota Toyoshima, Yusuke Kurosawa et autres

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Cigarette Smoke Extract–Induced Necroptosis Causes Mitochondrial DNA Release and Inflammation of Bronchial Epithelial Cells

Kenji Mizumura, Ryosuke Ozoe, Y Nemoto, Naho Furusho et autres

Purpose: Chronic obstructive pulmonary disease (COPD) is characterized by airway inflammation and structural changes in the lungs, including emphysema. Cigarette smoke exposure induces mitochondrial damage, necroptosis-mediated pulmonary epithelial cell death, and emphysematous changes. However, the association between these events and airway inflammation …

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Potential Utility of Combined Presepsin and LDH Tracking for Predicting Therapeutic Efficacy of Steroid Pulse Therapy in Acute Exacerbation of Interstitial Lung Diseases: A Pilot Study

Yuichiro Takeshita, Yasuo To, Masako To, Naho Furusho et autres

Background/Objectives: The usefulness of presepsin, which is released from macrophages, in acute exacerbation of interstitial lung diseases (AE-ILDs) is unknown. We aimed to investigate the utility of monitoring presepsin with other AE-ILD markers before and after steroid pulse therapy in AE-ILDs. Methods: …

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Novel humanized mouse model for steroid-resistant asthma

Shiho Yamada, Shuichiro Maruoka, Shota Toyoshima, Yusuke Kurosawa et autres

Novel humanized mouse model for steroid-resistant asthmaShiho Yamada, MD, PhDa,b,*, Shuichiro Maruoka, MD, PhDa,b,*,**, Shota Toyoshima, PhDa,c, Yusuke Kurosawa, MD, PhDa,b, Ryosuke Ozoea,b , MD, Yutaka Kozu, MD, PhDa,b, Kenji Mizumura, MD, PhDa,b, Yo

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Prognostic significance of oxygen saturation/fraction of inspired oxygen 3 days after initiation of tocilizumab treatment in patients with COVID-19

Yusuke Kurosawa, Yutaka Kozu, K. Soda, Yasunori Itoda et autres

Tocilizumab is effective in treating severe coronavirus disease 2019 (COVID-19). However, the specific time point it acts as a valid indicator of treatment efficacy remains unclear. This study aimed to determine the optimal day for assessing the prognostic value of the oxygen …

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Usefulness of Combined Measurement of Surfactant Protein D, Thrombin–Antithrombin III Complex, D-Dimer, and Plasmin–α2 Plasmin Inhibitor Complex in Acute Exacerbation of Interstitial Lung Disease: A Retrospective Cohort Study

Yuichiro Takeshita, Masako To, Yusuke Kurosawa, Naho Furusho et autres

Background/Objectives: The coagulation cascade due to tissue damage is considered to be one of the causes of poor prognostic outcomes in patients with acute exacerbations of interstitial lung disease (AE-ILD). This study aimed to confirm coagulopathy in AE-ILD by evaluating the differences …

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The Relationship between Leptin Levels and Continuous Positive Airway Pressure Treatment: A Cluster Analysis

Takashi Oki, Yutaka Kozu, Mamiko Hoshi, Yasunori Itoda et autres

Abstract Objective Leptin is an appetite-suppressing hormone released by adipose tissue that plays an important role in severe obstructive sleep apnea syndrome (OSAS). However, it is unclear whether leptin levels are a useful biomarker for this syndrome. The present study aimed to …

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Clinical characteristics and cytokine profiles of adult obese asthma with type2 inflammation

Masako To, Yoshihito Arimoto, Natsue Honda, Yusuke Kurosawa et autres

Obesity-related non-eosinophilic asthma has been identified as a phenotype of asthma. However, mepolizumab and omalizumab improve asthma control in severe asthma with obesity, implying that type-2 cytokines may be involved in the deterioration of control in obese asthma. Despite this, the clinical …

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A possibility of pulmonary intravascular coagulopathy in acute exacerbation of interstitial lung diseases: a retrospective cohort study

Yuichiro Takeshita, Masako To, Yusuke Kurosawa, Toru Kinouchi et autres

Abstract Background Acute exacerbation (AE) of interstitial lung disease (ILD) is a life-threatening condition that can cause idiopathic pulmonary fibrosis (IPF) and non-IPF. One of the causes of the poor prognostic outcomes of AE-ILD is believed to be the coagulation cascade due …

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