Harsh Shah

Success and Failure With the Antidyskinetic Effect of Globus Pallidus Internus Deep Brain Stimulation: A Sweet Spot and Connectivity Analysis in the CSP-468 Cohort

Shawn D’Souza, Harsh Shah, Vikram Seshadri, Jamie Toms et autres

OBJECTIVES: Deep brain stimulation (DBS) of the globus pallidus internus (GPi) can reduce levodopa-induced dyskinesias, yet GPi targeting sometimes fails or worsens them, suggesting distinct prokinetic/antikinetic circuit mechanisms. Using the broad globus pallidus (GP) sampling from the Veteran Affairs Cooperative Study Program …

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Predictors of motor outcome with pallidal stimulation for Parkinson’s disease from the CSP468 cohort

Shawn D’Souza, Aashish Batheja, Jeffrey Chen, Harsh Shah et autres

Deep brain stimulation (DBS) of the globus pallidus interna (GPi) is an effective treatment for medication‑refractory Parkinson’s disease (PD), though outcomes vary widely. The influence of lead location relative to the GPi therapeutic sweetspot has not previously been examined within a multivariable …

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New perspectives on cortical and subcortical mechanisms for visuomotor adaptation and their clinical implications

N Yaghoubi, Harsh Shah, Brian D. Berman, Brooke Dexheimer

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Pallidal Spectral and Phase-Amplitude Coupling Differences in Parkinson’s Disease Locomotor States

J Wallner, Nicholas Druck, Harsh Shah, Leslie J. Cloud et autres

Abstract Background Deep brain stimulation of the subthalamic nucleus or Globus Pallidus internus is an established therapy for Parkinson’s Disease that is sub-optimally managed with medication. While post-operative motor studies have defined neurophysiological signatures of the subthalamic nucleic local field potentials, comparable …

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Axillary Cavernous Hemangioma: A 3D-printed Model

Alyssa Habermann, Elizabeth Bashian, Harsh Shah, Kelsey A. Atkinson et autres

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Quantification of In Situ Ulnar Nerve Strain and Constraint Tension in the Forearm

Mark Carl Miller, Patrick J. Schimoler, Harsh Shah, Alexander Kharlamov et autres

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Retrospective Analysis of accurate position of Different Implant Systems Using Mucosa-Supported Surgical Templates

Shashank Vijapure, Aaquib Nazir, Angel Aghera, Jewel Ipsita Sahani et autres

Background: Accurate implant positioning is critical for long-term success in implant dentistry. Mucosa-supported surgical templates have gained popularity in edentulous cases due to their non-invasive nature and improved patient comfort. However, limited comparative data exist regarding their accuracy across different implant systems. …

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Endoscopic Endonasal C1-C2 Spinal Cord Decompression

Peter Kwak, Srihari Daggumati, Lawrance Lee, Harsh Shah et autres

Endoscopic endonasal approach for resection of the odontoid process was first described by Kassam et al in 2005. Since then, it has gained popularity in carefully selected patients over traditional transoral approaches due to its minimally invasive nature and promising clinical outcomes. …

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Precision targeting in the globus pallidus interna: insights from the multicenter, prospective, blinded VA/NINDS CSP 468 study

Shawn D’Souza, Vikram Seshadri, Jamie Toms, Pierre D’Haese et autres

OBJECTIVE: Deep brain stimulation (DBS) targeting the globus pallidus interna (GPi) has been shown to significantly improve motor symptoms for the treatment of medication-refractory Parkinson's disease. Yet, heterogeneity in clinical outcomes persists, possibly due to suboptimal target identification within the GPi. By …

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Management of rare atlantoaxial synovial cyst case with extension to the cerebellopontine angle: illustrative case

Shawn D’Souza, Vikram Seshadri, Harsh Shah, Jan T. Hachmann et autres

BACKGROUND: Synovial cysts are a common finding in degenerative spine disease, most frequently involving the facet joints of the lumbar spine. Synovial cysts are less common in the cervical spine and rarely involve the atlantoaxial junction. OBSERVATIONS: In this case report, the …

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The Poised Cannula Technique Reduces the Stereotactic Error of the Fiducial-Less Frameless DBS Procedure

Matthew Moser, Paul Koch, Harsh Shah, Alen Docef et autres

BACKGROUND: In this study, we describe a technique of optimizing the accuracy of frameless deep brain stimulation (DBS) lead placement through the use of a cannula poised at the entry to predict the location of the fully inserted device. This allows real-time …

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Therapeutic approaches to cholinergic deficiency in Lewy body diseases

Matthew J. Barrett, Leslie Cloud, Harsh Shah, Kathryn L. Holloway

Introduction: Cortical cholinergic denervation resulting from degeneration of the nucleus basalis of Meynert (NBM) is a primary contributor to cognitive impairment and neuropsychiatric symptoms in the Lewy body diseases Parkinson’s disease (PD), Parkinson’s disease dementia (PDD), and dementia with Lewy bodies (DLB). …

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