Zuxi Jin

Pinnick Oxidation on Scale: Process Development of a BDK Inhibitor

Joel T. Arcari, Catherine Buckley, Leanne M. Buzon, Yongbo Dan et autres

The development of a safe and scalable Pinnick oxidation of an aldehyde to a carboxylic acid in the late-stage synthesis of a BDK inhibitor candidate, PF-07208254, is reported. Extensive process safety testing revealed a large exotherm with significant heat accumulation during oxidant …

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A fast and environment-friendly method for preparing nanopowders Mo through electro- desulfidation of MoS2 in LiCl melt

Haiping Gao, Zuxi Jin, Keyu Hu, Yanguo Zhang et autres

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Demonstration of a Multikilogram-Scale Birch Reduction and Evaluation of Alternative Synthetic Routes to a Ketalized Cyclohexene Derivative

Adam E. Goetz, Joel T. Arcari, Scott W. Bagley, Robert W. Hicklin et autres

We report the successful manufacture of several >50 kg batches of a key intermediate via a Birch reduction that utilized liquified ammonia as well as lithium metal. With an eye toward continued scalability, we explored two alternative procedures to obtain the same …

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ChemInform Abstract: Application of Hantzsch Dihydropyridine in Copper‐Catalyzed [3 + 2] Cycloaddition of Terminal Alkynes with Azides.

Zuxi Jin, Peng Xue, Enqin Fu

Abstract Dihydropyridine Hantzsch ester in combination with CuSO4 represents an efficient catalyst system for the synthesis of 1,4‐disubstituted triazoles (23 examples) via click reactions.

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Synthesis and Structure of a Novel Alkynyl-Containing Disulfide Compound as Cathode Materials for Secondary Lithium Batteries

Zuxi Jin, Yun-guo Lu, Shixi Li, Zaoying Li

A novel alkynyl-containing disulfide compound, 5,8-dihydro-1H,4H-2,3,6,7-tetrathia-anthracen (TMSEDTTA), was synthesized. The structures of the target compound and the intermediates have been identified by 1H NMR, 13C NMR, mass spectrometry, Fourier-transform infrared, Raman spectra, x-ray photoelectron spectroscopy, and elemental analysis. In addition, the structure …

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Application of Hantzsch Dihydropyridine in Copper-Catalyzed [3 + 2] Cycloaddition of Terminal Alkynes with Azides

Zuxi Jin, Peng Xue, Enqin Fu

2,6-Dimethyl-3,5-bis(ethoxycarbonyl)-1,4-dihydropyridine (dihydropyridine Hantzsch ester, DHPHE) and CuSO4 · 5H2O efficiently accelerated azide–alkyne cycloaddition reactions of both aliphatic and aromatic substrates and gave 1,4-disubstituted 1,2,3-triazoles as the only isomer in good to excellent yields at room temperature with 1 mol% of CuSO4 · …

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Synthesis and properties of novel phenylethynyl-containing organodisulfide as cathode material for secondary lithium batteries

Zuxi Jin, Hai Tao Zhong, Shixi Li, Zaoying Li

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A new phosphonamidate as flame retardant additive in electrolytes for lithium ion batteries

Jianlin Hu, Zuxi Jin, Hai Tao Zhong, Hui Zhan et autres

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