Mahavir H. Ghante

Synthesis and Anticancer Activity of Diethyl (((5-(substituted phenyl)-1,3,4-thiadiazol-2-yl)amino)(quinolin-2-yl)methyl)phosphonate

Shailee V. Tiwari, Mahavir H. Ghante, Dattatraya N. Pansare, Nileema S. Gore et autres

Abstract Objective: This study reports the efficient catalysis of a three-component reaction involving 5-(substituted phenyl)-1,3,4-thiadiazol-2-amine (IIIa–IIIq), quinoline-2-carbaldehyde, and triethyl phosphite, using zirconium oxychloride (ZrOCl2) as a catalyst in ethanol under reflux conditions. The reaction yields α-aminophosphonates in good to excellent yields. Notably, …

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Approaches for tight junction opening

Mahavir H. Ghante, Achal Mishra, Ashish Kumar Pandey, S. K. Jain et autres

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List of contributors

Arpit Bhargava, Bindiya, Nagendra S. Chauhan, Sri Pada Datta Chigurupati et autres

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In Silico PASS Predictions and Exploration of Antioxidant and Anti-inflammatory Activity of Citrus Karna Raf. Fruit

Prasad G. Jamkhande, Mahavir H. Ghante, Rajeshwar KSHIRSAGA

Objective: Inflammation and oxidative stress are major factors in the development of many disorders.Natural antioxidants present in plants can interrupt, decrease, or reduce the oxidation of components sensitive to oxidative processes by scavenging free radicals and lowering oxidative stress.Most anti-inflammatory agents used …

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Pharmacological Investigation of Pithecellobium dulce Stem Bark extract for Anti-Depressant Activity on Mice and Rats

Shankar S. Khandare, Rajesh B. Jadhav, Kavita A. Pimpre, A. Munde et autres

Pithecellobium dulce (PD), commonly known as Jangli-jilebi, is a Manila tamarind belonging to the family Leguminosae. P. dulce (PD) is used to treat various diseases like diarrhea, asthma, leprosy, paralysis, inflammatory, anti-bacterial, spermicidal, anti-convulsant, etc. In this paper, we studied the activity …

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In silico PASS prediction and evaluation of antitumor and anti-angiogenic activity of peel extracts of Citrus karna Raf. fruit

Prasad G. Jamkhande, Mahavir H. Ghante

Inhibition of angiogenesis is one of the significant contrivance to suppress the developing tumor.Several previous studies have shown that phytochemicals can modify numerous vital processes of tumor promotion.However, there is no literature evidence of investigation on antitumor and antiangiogenic activity of Citrus …

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Isolation and Characterization of Anti-Inflammatory Compounds from Ficus microcarpa L.f. Stem Bark

Mohan Kalaskar, Vivek Redasani, Muniappan Ayyanar, Mahavir H. Ghante et autres

The anti-inflammatory effect of the ethyl acetate extract of F. microcarpa bark (EAFMB) was investigated in acute and chronic (21 days) inflammation induced in Wistar albino rats. EAFMB (200 mg/kg b.w.) exhibited comparable anti-inflammatory effects to the reference drug, with a reduction …

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Bioactivity-guided Isolation of Phytoconstituents from Saraca asoca Seeds for Anti-asthmatic Potential

Chandrakant P. Rathod, Mahavir H. Ghante

Objectives: It is interesting to consider biologically active substances derived from natural sources as potential novel medications for infectious disorders.Saraca asoca is an indigenous medicinal plant with lots of traditional importance belonging to the family Caesalpinaceae.As these plants have been ethno-pharmacologically claimed …

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Pharmacological screening of mast cell stabilizing, anti-inflammatory and anti-oxidant activity of Calotropis proceraextracts

Chandrakant P. Rathod, Mahavir H. Ghante

Calotropis procera (Ait.) R. Br., a wild growing plant of family Asclepiadaceae, is well knownfor its medicinal properties which is widely used in traditional medicine to treat various diseases.C. procera flowers showed various levels of preliminary phytochemical screening of extract hasrevealed the …

Pharmacological Importance of Saraca asoca: A Review

Chandrakant P. Rathod, Mahavir H. Ghante

Ayurveda is a traditional medicinal system which has been used consistently. Asoka is one of India's most holy and legendary trees. Ashoka, also known as Saraca asoca (Roxb.) Wilde, is an indigenous plant that belongs to the Caesalpiniaceae subfamily of the Legume. …

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Development, Validation of RP-HPLC Method and GC MS Analysis of Desloratadine HCL and IT"s Degradation Products

Ashish B Roge, Sagar N Firke, Shrinivas K. Sarje, Mahavir H. Ghante et autres

Introduction: Efficacy and safety of drug therapy is directly related to the stability of active pharmaceutical ingredient (API) and drug product used. Forced degradation studies (also called stress testing) are performed for better understanding of API and drug product stability. Thus, stress …

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Antimycobacterial, antimicrobial, antioxidant activities and in silico PASS investigations of root fractions and extract of Cordia dichotoma Forst

Prasad G. Jamkhande, Mahavir H. Ghante, Sonal Ramrao Barde, Balaji R. Ajgunde

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