Pharmacological Investigation of Pithecellobium dulce Stem Bark extract for Anti-Depressant Activity on Mice and Rats
Rattachement africain : in. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Pithecellobium dulce (PD), commonly known as Jangli-jilebi, is a Manila tamarind belonging to the family Leguminosae. P. dulce (PD) is used to treat various diseases like diarrhea, asthma, leprosy, paralysis, inflammatory, anti-bacterial, spermicidal, anti-convulsant, etc. In this paper, we studied the activity of P. Dulce for depression, which is a debilitating, life-threatening, and common disease affecting different sections of the community. Chemical and synthetic medications used to treat this disease have significant negative side effects, and only 50–60% of patients fully recover. At the same time, the available scientific information about this species is scarce, and there are no reports related to its possible effects on the central nervous system. In this work, the effects of acetone and methanolic extracts of the stem bark of P. dulce (PD) were evaluated in mice and rats utilizing behavioral assays sensitive to clinically effective anti-depressant compounds. In both the forced swim test and the tail suspension test, the extracts (100 and 200 mg/kg) administered orally were able to shorten the immobility duration of mice and rats in a dose-dependent manner. According to the current study's findings, PD extract may have antidepressant potential and be useful in treating those who suffer from depressive disorders. These findings proved that PD has specifically anti-depressive in vivo effects.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Pharmacological Investigation of Pithecellobium dulce Stem Bark extract for Anti-Depressant Activity on Mice and Rats
- Date Crossref
- 20/02/2024
- Éditeur
- A and V Publications
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
-
Sanskriti Samvardhan Mandal pays non établi dans la noticeInstitution
-
s Indira College of Pharmacy SCES pays non établi dans la noticeUniversité ou école supérieure
-
Raosaheb Patil Danve College of Pharmacy pays non établi dans la noticeUniversité ou école supérieure
-
National Institute of Pharmaceutical Education and Research pays non établi dans la noticeStructure de recherche
-
Nanded Pharmacy College pays non établi dans la noticeUniversité ou école supérieure
Sanskriti Samvardhan Mandal, SCES — s Indira College of Pharmacy et Raosaheb Patil Danve College of Pharmacy, avec 2 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.