Jussara Bianchi Castelli

MM-271: Efficacy of Daratumumab-Based Treatment in Brazilian Patients With Systemic Light Chain Amyloidosis: A Real-World Single-Center Retrospective Study

Moysés Antonio Porto Soares, Juliana Matos Pessoa, Jussara Bianchi Castelli, Fábio R. Kerbauy et autres

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Assessing the consistency of mass spectrometry, a clinical-laboratory model, and immunohistochemistry in amyloid subtyping: a Brazilian experience

Roberta Shcolnik Szor, Jussara Bianchi Castelli, Rodrigo Andrade Schuch, Valdemir Melechco Carvalho et autres

BACKGROUND: Systemic amyloidosis is a potentially fatal protein misfolding disorder usually underdiagnosed in low- and middle-income countries, where limited awareness and restricted access to diagnostic tools contribute to prolonged diagnostic journeys and delayed diagnoses. Accurate identification of the precursor protein is essential …

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Mapping Amyloid Subtypes in Brazil through Mass Spectrometry: Results of a Diagnostic Support Program

Jussara Bianchi Castelli, Roberta Shcolnik Szor, Ana Paula Alves

Objectives: Amyloidosis results of tissue deposition of misfolded proteins aggregates, leading to localized or systemic forms. Over 40 proteins are amyloidogenic, the main 2 being immunoglobulin light chain (AL) and transthyretin (ATTR). Mass spectrometry (MS) is the gold-standard for subtyping amyloid. Despite …

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MAPPING AMYLOID SUBTYPES IN BRAZIL THROUGH MASS SPECTROMETRY: RESULTS OF A DIAGNOSTIC SUPPORT PROGRAM

Jussara Bianchi Castelli, Roberta Shcolnik Szor, Arminda Alves, Analú Egydio Jacomini

Amyloidosis results of tissue deposition of misfolded proteins aggregates, leading to localized or systemic forms. Over 40 proteins are amyloidogenic, the main 2 being immunoglobulin light chain (AL) and transthyretin (ATTR). Mass spectrometry (MS) is the gold-standard for subtyping amyloid. Despite MS …

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Proteomic Analysis of Glomerular Extracellular Matrix Suggests a Potential Role of Complement in the Pathogenesis of Idiopathic Collapsing Glomerulopathy Associated with APOL1 High-Risk Genotypes

Precil Diego Miranda de Menezes Neves, Talita Souza Siqueira, Valkercyo A. Feitosa, Andréia Watanabe et autres

Background: The pathogenesis of collapsing glomerulopathy (CG), a highly aggressive nephropathy, remains largely unclear. While a significant fraction of idiopathic CG (ICG) cases is associated with APOL1 high-risk genotypes (HRG), the differences in pathogenic processes between ICG associated with HRG (ICG+HRG) and …

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new insights into the pathophysiology of rheumatic valve disease based on different genetic and proteomics profiles

A Almeida Valadares, Ana Martins, Jussara Bianchi Castelli, V Melechco et autres

Abstract Introduction Rheumatic heart disease (RHD) pathogenesis is not fully understood. Purpose The protein profile in rheumatic heart disease may have a different fingerprint in the aortic and mitral valves, which results in different evolution in terms of valve damage. Methods To …

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P-309 Diagnostic Challenges in Systemic Amyloidosis: Exploring the Impact of Mass Spectrometry in a Middle-Income Country Cohort

Roberta Shcolnik Szor, Jussara Bianchi Castelli, Rodrigo Andrade Schuch, Valdemir Melechco Carvalho et autres

Beneath HMGA2 alterations in pleomorphic adenomas: Pathological, immunohistochemical, and molecular insights

Ziyad Alsugair, Charles Lépine, Françoise Descôtes, Marie‐Delphine Lanic et autres

AIMS: Most salivary gland neoplasms are distinguished by specific recurrent gene fusions. Recently, a subset of pleomorphic adenomas (PAs) originated from the parotid gland harboring the HMGA2:WIF1 fusion was described with a canalicular adenoma-like morphology and a greater propensity for recurrence and …

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Challenges in Amyloidosis Typing: The Role of Mass Spectrometry in a Middle-Income Country PA74 (#410)

Roberta Shcolnik, Jussara Bianchi Castelli, Valdemir Melechco Carvalho, Vanderson Rocha

An Unusual Journey: From Systemic to Localized AL Amyloidosis PA73 (#407)

Roberta Shcolnik, Jussara Bianchi Castelli, Liliana Cavalcanti

ENDOCARDITE INFECCIOSA POR BARTONELLA. SPP: SERIE DE CASOS EM TRÊS HOSPITAIS UNIVERSITÁRIOS

Juliana Roberta Mottta Ragozzino, Ana Maria Thomaz, Diego Augusto Medeiros Santos, Tânia Mara Varejão Strabelli et autres

Endocardite infecciosa é uma doença grave, com elevada morbidade e mortalidade. O diagnóstico muitas vezes é tardio devido à sua apresentação clínica diversificada. Entre as causas da endocardite infecciosa, a infecção por Bartonella spp. tem sido reconhecida como um importante diagnóstico diferencial, …

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Proteomics by Mass Spectrometry in the Typing of Amyloidosis

Jussara Bianchi Castelli, Valdemir Melechco Carvalho

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