Accès ouvert déclaré
2024
article
Beneath HMGA2 alterations in pleomorphic adenomas: Pathological, immunohistochemical, and molecular insights
Ziyad Alsugair, Charles Lépine, Françoise Descôtes, Marie‐Delphine Lanic, Daniel Pissaloux, Franck Tirode, Jonathan Lopez, Philippe Céruse, Pierre Philouze, M. Fieux, Michel Wassef, A.C. Baglin, Onea Mihaela, Claire Castain, Anne Sudaka, Emmanuelle Uro‐Coste, Anne Champagnac, Valérie Costes‐Martineau, Marick Laé, Nazim Benzerdjeb, C. Ala-Eddine, Karine Aubry, E. Babin, C Bach, Cécile Badoual, Brenda J. Barry, Vianney Bastit, B. Baujat, K. Bénézéry, René‐Jean Bensadoun, Maureen Bernadach, C. Bertolus, A. Biet, Daniel Bodmer, P. Boisselier, Camille Boulagnon‐Rombi, Laurence Bozec, Alexis Bozorg Grayeli, Esteban Brenet, L. Brugel, G. Calais, Valentin Calugaru, Séverine Camby, Odile Casiraghi, E. Cassagnau, Jussara Bianchi Castelli, F. Chabolle, D. Chevalier, O. Choussy, F. Clatot, Jean‐Marc Constans, A. Coste, F Coste, Valérie Costes, Jean‐Philippe Cottier, Alexandre Coutté, J. Cristofari, D. Cupissol, Jean Delgrande, J.P. Delord, B. Devauchelle, L. Digue, G. Dolivet, Monique Doré, Suzy Duflo, X. Dufour, Charles Dupin, E. Eker, Caroline Even, C Evrard, Emily Fabiano, Sandrine Faivre, Nicolas Fakhry, François‐Régis Ferrand, Julien Frandon, D. Franetti, L. de Gabory, Camille Galy, Martin Garcier, R. Garrel, H. Gauthier, L. Gilain, S. Guihard, S. Guillerm, C. Halimi, Stéphane Hans, P. Herman, Aline Houessinon, Muriel Hourseau, F. Huguet, É. Jadaud, R. Jankowski, C. Jeanne, F. Jegoux, M. Juliéron, Rachid Kaci, Marie‐Christine Kaminsky, H. De Kermadec, F. Kolb, S. Kreps, Mouna Laadhari, Jean Lacau Saint Guily, L. Laccoureye, François Lagarde, Aurélie Lagrange, Benjamin Lallemant, Michele Lamuraglia, P Lang, M. Lapeyre, Ariane Lapierre, A.Lasne Cardon, C. Le Tourneau, Guillaume Lefebvre, Marie Lefèvre, Yann Lelonge, Xavier Leroy, Philippe Lesnik, X. Liem, Claude Linassier, P. Maingon, Claire Majoufre, O. Malard, Gabriel G. Malouf, C. Marchand, Jean Pierre Marie, Tristan Maurina, Olivier Mauvais, Jean‐Claude Mérol, J. Michel, G. Mineur, Sonia Mirafzal, H. Mirghani, Adriana Modesto, S. Molinier-Blossier, Erwan de Monès, S. Morinière, F. Mouawad, Antoine Moya‐Plana, Laurent Muller, E. Musat, F. Nguyen, G Noël, F.R. Obongo-Anga, Mihaela Onea, Hélène Orliac, Clive Page, Vincent Patron, J. Pestre, N. Pham Dang, Pierre Philouze, G. Poissonnet, Cristina Pons, Camille Pouliquen, J.-M. Prades, A. Prévost, Catarina Queirós, Arshad Husain Rahmani, Audrey Rambeau, Lionel Ramin, S. Renard, Alena Siegfried, C.A. Righini, Frédéric Rolland, Esma Saâda, F. Sacino, Sébastien Salas, N. Saroul, P. Schultz, Audrey Simonaggio, Olivier Sterkers, V. Strunski, S. Xu-Shan, R. Taouachi, M. Tassart, S. Testelin, J Thariat, M. Timar David, A. Timochenko, B. Toussaint, E. Uro Coste, G Valette, T. Van den Abbele, A. Varoquaux, Élodie Vauléon, S. Vergèz, B. Verillaud, Juliana Villa, Aude Villepelet, M. Volondat, N. Vulquin, I. Wagner, L. Webert, Sze Chuen Cesar Wong
10Citations signalées — pas une note de qualité
19Institutions déclarées
1Pays d’affiliation déclarés
Résumé fourni par la source
AIMS: Most salivary gland neoplasms are distinguished by specific recurrent gene fusions. Recently, a subset of pleomorphic adenomas (PAs) originated from the parotid gland harboring the HMGA2:WIF1 fusion was described with a canalicular adenoma-like morphology and a greater propensity for recurrence and carcinomatous transformation. METHODS AND RESULTS: This study delineates the clinicopathological attributes of 54 cases of PAs exhibiting HMGA2 alterations, predominantly characterized by the HMGA2:WIF1 fusion, alongside a comparative analysis of their morphological and immunohistochemical profiles. The cohort consisted of 23 females and 31 males (n = 54), mean age was 56.7 (25-84), tumors predominantly originated from the parotid gland (94.4%, 51/54), with 3 cases from seromucous glands (5.6%). Mean tumor size was 2.6 cm (0.8-7.5). No clinical difference (demographic, follow-up) was observed among histological subsets (conventional, hybrid, and pure). Complete excision was performed in all cases, with follow-up data available for 41% (22/54) of patients, showing 13.6% of recurrence (3/22) between 5 and 8 months. Various histological growth patterns were identified, with the pure hypercellular monomorphic subset being the most prevalent. The HMGA2:WIF1 gene was identified in all subsets without any particular predominance. Novel gene partners of HMGA2 were identified, comprising NRXN1, INPP4B, MSRB3, PHLDA1, and FLJ41278. CONCLUSIONS: The present study reports that the HMGA2:WIF1 gene fusion was present in all subsets of PAs without significant predominance. However, further investigations are warranted to explore the relationship between histological subsets of PAs and the molecular alterations underlying them.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Beneath HMGA2 alterations in pleomorphic adenomas: Pathological, immunohistochemical, and molecular insights
- Date Crossref
- 01/10/2024
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude et ne compte pas comme une seconde source scientifique indépendante.
Institutions déclarées
Une affiliation ne permet pas de déduire la nationalité d’un auteur.
Sujets associés
Salivary Gland Tumors Diagnosis and TreatmentEar and Head TumorsSalivary Gland Disorders and Functions