Emily J. Lodge

Consensus Pituitary Atlas, a scalable resource for annotation, novel marker discovery and analyses in pituitary gland research

Bence Kövér, Thea L. Willis, Olivia Sherwin, James Kaufman-Cook et autres

Summary Previous single-cell profiling studies of the pituitary gland have yielded minimally reproducible insights largely due to their low statistical power and methodological inconsistencies. To address this problem, we generated a uniformly pre-processed Consensus Pituitary Atlas (CPA) using all existing mouse pituitary …

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Unravelling the core regulatory network controlling stem cell fate in the anterior pituitary

B Kövér, Emily J. Lodge, James Kaufman-Cook, Yasmine Kemkem et autres

SOX2+ sustentacular cells are stem cells of the postnatal adrenal medulla

Alice Santambrogio, Yasmine Kemkem, Thea L. Willis, Ilona Berger et autres

Abstract Renewal of the catecholamine-secreting chromaffin cell population of the adrenal medulla is necessary for physiological homeostasis throughout life. Definitive evidence for the presence or absence of an adrenomedullary stem cell has been enigmatic. In this work, we demonstrate that a subset …

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SOX2 sustentacular cells are stem cells of the postnatal adrenal medulla

Alice Santambrogio, Yasmine Kemkem, Thea L. Willis, Ilona Berger et autres

Renewal of the catecholamine-secreting chromaffin cell population of the adrenal medulla is necessary for physiological homeostasis throughout life. Definitive evidence for the presence or absence of an adrenomedullary stem cell has been enigmatic. In this work, we demonstrate that a subset of …

SOX2 sustentacular cells are stem cells of the postnatal adrenal medulla

Alice Santambrogio, Yasmine Kemkem, Thea L. Willis, Ilona Berger et autres

Renewal of the catecholamine-secreting chromaffin cell population of the adrenal medulla is necessary for physiological homeostasis throughout life. Definitive evidence for the presence or absence of an adrenomedullary stem cell has been enigmatic. In this work, we demonstrate that a subset of …

SOX2 + sustentacular cells are stem cells of the postnatal adrenal medulla

Alice Santambrogio, Yasmine Kemkem, Thea L. Willis, Ilona Berger et autres

Summary Renewal of the catecholamine-secreting chromaffin cell population of the adrenal medulla is necessary for physiological homeostasis throughout life. Definitive evidence for the presence or absence of an adrenomedullary stem cell has been enigmatic. In this work, we demonstrate that a subset …

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The Fuzzy planar cell polarity protein ( FUZ ), necessary for primary cilium formation, is essential for pituitary development

Emily J. Lodge, William B. Barrell, Karen J. Liu, Cynthia L. Andoniadou

Abstract The primary cilium is an essential organelle that is important for normal cell signalling during development and homeostasis but its role in pituitary development has not been reported. The primary cilium facilitates signal transduction for multiple pathways, the best‐characterised being the …

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Generation of novel tools for the study and development of targeted therapeutic approaches for pheochromocytoma and paraganglioma

Yasmine Kemkem, Alice Santambrogio, Bertille Montibus, Thea L. Willis et autres

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

Cellular interactions in the pituitary stem cell niche

Thea L. Willis, Emily J. Lodge, Cynthia L. Andoniadou, Val Yianni

Stem cells in the anterior pituitary gland can give rise to all resident endocrine cells and are integral components for the appropriate development and subsequent maintenance of the organ. Located in discreet niches within the gland, stem cells are involved in bi-directional …

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Generation of novel tools for the study and development of targeted therapeutic approaches for pheochromocytoma and paraganglioma

Yasmine Kemkem, Alice Santambrogio, Bertille Montibus, Sherwell Sanchez Carlos Abascal et autres

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

BRF1-mediated paracrine signalling from pituitary stem cells is required for terminal differentiation of pituitary committed progenitors

Thea L. Willis, Saba Manshaei, Virinder Reen, Husayn Ahmed Pallikonda et autres

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

FUZ is required for SHH-mediated pituitary development

Emily J. Lodge, William B. Barrell, Karen J. Liu, Cynthia L. Andoniadou

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)