Saba Manshaei

OC5.4 - ECE_3532 - Constitutive active expression of ZFP36L1 in anterior pituitary SOX2+ stem cells results in pituitary hypoplasia and a failure of terminal differentiation via a non-cell autonomous mechanism

Olivia Sherwin, Saba Manshaei, Thea Willis, Hiba Hamdi et autres

Abstract SOX2+ pituitary stem cells (PSCs) are a critical source of signalling cues during pituitary development, yet the molecular orchestrators of this paracrine environment remain poorly defined. In this study, we identify ZFP36L1 as a key regulator of secreted factor expression within …

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Restoring Shugoshin 1 reduces chromosome errors in human eggs

Debojit Saha, Saba Manshaei, Tommaso Cavazza, Zuzana Holubcová et autres

Abstract Aneuploidy in human eggs, which rises sharply with age, is a leading cause of infertility, IVF failure, and miscarriage. This age-related aneuploidy is primarily driven by premature sister chromatid separation (PSSC), resulting from loss of the cohesin complex that holds chromatids …

de, cz, Mozambique, gb (code pays fourni par la source)

CP-03. EXTRACELLULAR MATRIX REMODELING REVEALS NON-CELL AUTONOMOUS TUMOR FORMATION MECHANISM IN ADAMANTINOMATOUS CRANIOPHARYNGIOMAS

John Jeang, Danny Jomaa, Dana R. Novikov, Jessica W. Tsai et autres

Abstract Adamantinomatous Craniopharyngioma (ACP) is a rare pituitary tumor of the sellar region, with a bimodal presentation pattern in children and middle-aged adults. ACPs are primarily driven by a mutation in CTNNB1 that prevents beta-catenin from degrading properly, resulting in accumulation in …

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Clearance of senescent macrophages ameliorates tumorigenesis in KRAS-driven lung cancer

Scott Haston, Estela González‐Gualda, Samir Morsli, Jianfeng Ge et autres

The accumulation of senescent cells in the tumor microenvironment can drive tumorigenesis in a paracrine manner through the senescence-associated secretory phenotype (SASP). Using a new p16-FDR mouse line, we show that macrophages and endothelial cells are the predominant senescent cell types in …

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BRF1-Mediated Paracrine Signalling by a Subset of SOX2-Expressing Stem Cells is required for Normal Development of the Stem Cell Compartment and Terminal Differentiation of Pituitary Committed Progenitors

Juan Pedro Martı́nez-Barberá, Saba Manshaei, Thea L. Willis, Virinder Reen et autres

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

RF13 | PMON143 BRF1-Mediated Paracrine Signalling by a Subset of SOX2-Expressing Stem Cells is Required for Normal Development of the Stem Cell Compartment and Terminal Differentiation of Pituitary Committed Progenitors

Saba Manshaei, Thea L. Willis, Virinder Reen, Husayn Ahmed Pallikonda et autres

Abstract Introduction Hormone-producing pituitary cell lineages are derived from a population of embryonic precursors expressing SOX2. These cells maintain multipotency into early postnatal life, acting as the resident population of pituitary stem cells (PSCs) and contributing extensively to all the endocrine cell …

BRF1-mediated paracrine signalling from pituitary stem cells is required for terminal differentiation of pituitary committed progenitors

Thea L. Willis, Saba Manshaei, Virinder Reen, Husayn Ahmed Pallikonda et autres

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

Paracrine Signalling From SOX2-Expressing Pituitary Embryonic Cells Is Required for Terminal Differentiation of Hormone-Producing Cells

Saba Manshaei, Thea L. Willis, Dominic J. Withers, Jesús Gil et autres

Abstract The pituitary gland is the master regulator of the endocrine system, housing six major hormone producing cell types. This gland is derived from Rathke’s Pouch, an invagination of the oral ectoderm. Hormone-producing pituitary cell lineages are derived from a population of …

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Cardiac glycosides are broad-spectrum senolytics

Ana T.G. Guerrero, Nicolás Herranz, Bin Sun, Verena Wagner et autres

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Tumour compartment transcriptomics demonstrates the activation of inflammatory and odontogenic programmes in human adamantinomatous craniopharyngioma and identifies the MAPK/ERK pathway as a novel therapeutic target

John Richard Apps, Gabriela Carreno, José Mario González-Meljem, Scott Haston et autres

Adamantinomatous craniopharyngiomas (ACPs) are clinically challenging tumours, the majority of which have activating mutations in CTNNB1. They are histologically complex, showing cystic and solid components, the latter comprised of different morphological cell types (e.g. β-catenin-accumulating cluster cells and palisading epithelium), surrounded by …

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Stem/progenitor cells in pituitary organ homeostasis and tumourigenesis

Scott Haston, Saba Manshaei, Juan Pedro Martı́nez-Barberá

clonogenicity assays, flow cytometric side population analysis, immunohistochemical analysis and genetic approaches. These cells have been demonstrated to be able to self-renew and undergo multipotent differentiation to give rise to all hormonal lineages of the anterior pituitary. Furthermore, evidence exists for their …

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MAPK pathway activation in the embryonic pituitary results in stem cell compartment expansion, differentiation defects and provides insights into the pathogenesis of papillary craniopharyngioma

Scott Haston, Sara Pozzi, Gabriela Carreno, Saba Manshaei et autres

Despite the importance of the RAS-RAF-MAPK pathway in normal physiology and disease of numerous organs, its role during pituitary development and tumourigenesis remains largely unknown. Here we show that the over-activation of the MAPK pathway, through conditional expression of the gain-of-function alleles …

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