Demetrius M. Maraganore

Duration‐dependent Effects of Diet on Cognition and Gut Microbial Composition in an Aging Rat Model

Rebecca J Solch‐Ottaiano, Madison Prats, Malaika Subramanian, Nicholas Prus et autres

BACKGROUND: Dietary adherence is associated with the risk of cognitive decline and Alzheimer's disease. A Western diet (WD) is associated with increased risk, while a Mediterranean diet (MeDi) is associated with decreased risk. The gut microbiota may play a role in mediating …

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Abstract 4362857: Diet and Fecal Microbiota Transplantation Modulates Measurements of Cardiometabolic Health in Aging Animals: Preliminary Results

Madison Prats, Demetrius M. Maraganore, Rebecca J. Solch-Ottaiano

Background: The Western diet (WD) is associated with the development of diseases such as cardiovascular disease. Shifting from a WD to a health-promoting diet, such as a Mediterranean diet (MeDi), is an established intervention, but there is low adherence. Therefore, targeting the …

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Abstract 4354018: The Joint Effects of Life’s Essential 8 and Genetics on Cognitive Impairment and Dementia Risk in People with Diabetes: Findings from the UK Biobank and All of Us

Yilin Yoshida, Xiu Wu, Yue Zhao, David R. Crosslin et autres

Background: Diabetes is associated with increased risks of cognitive dysfunction and dementia. Although genetic risk for dementia is often seen as deterministic, healthy lifestyles may attenuate its impact. We investigated how Life’s Essential 8 (LE8) and genetic risk for dementia jointly affect …

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Implementation of an Alzheimer’s Disease Blood Test: Adoption Experience by Memory Care Specialists in a Multi-Center Study

Mark Monane, Kim G. Johnson, Darren R. Gitelman, Lawren A. VandeVrede et autres

Background/Objectives: A high-performing blood biomarker (BBM) test for Alzheimer’s disease (AD) represents an accurate, accessible, and scalable tool to aid healthcare professionals (HCPs) evaluating patients presenting with signs or symptoms of mild cognitive impairment (MCI) or dementia. However, implementation of AD blood …

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Comparing Mediterranean and Western Diets: Cognitive and Microbiota Effects in Middle-Aged Rats

Rebecca J. Solch-Ottaiano, C Alex Harper, Madison Prats, Elizabeth B. Engler-Chiurazzi et autres

Background: As the global population continues to age, cognitive decline has emerged as a major area of concern. Modifiable lifestyle factors, such as diet, have been associated with the trajectory of brain aging. Dietary patterns such as the Western diet (WD) have …

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Integrative snRNA‐seq, molecular docking and dynamics simulations identifies Lasmiditan as drug candidate for Alzheimer's disease

Martin C. Nwadiugwu, Md. Selim Reza, Boluwatife Afolabi, Demetrius M. Maraganore et autres

Abstract Background Alzheimer's disease (AD) is a growing healthcare crisis with limited effective therapies. This study aims to identify new candidate drugs that can be repurposed using key transcriptional regulators (DERs) in AD as therapeutic targets. Methods Multi‐cohort single‐nucleus RNA sequencing (snRNA‐seq) …

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Abstract TP46: Longitudinal Effects of Diet on Cognitive Function and Fecal Metabolites in Two Genetically Diverse Wild-type Rat Strains

Rebecca J. Solch-Ottaiano, Madison Prats, Nicholas Prus, Irene S. Yu et autres

Background: Modifiable lifestyle factors such as diet and genetic predisposition influence cognitive aging. The Mediterranean diet (MeDi) is associated with healthy brain aging while the Western diet (WD) is associated with cognitive impairment. Genetics may interact with dietary patterns to further impact …

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Migraine Genetic Susceptibility Does Not Strongly Influence Migraine Characteristics and Outcomes in a Treated, Real-World, Community Cohort

Bruce A. Chase, Roberta Frigerio, Susan E. Rubin, Irene Semenov et autres

Background/Objectives: Migraine is a common neurological disorder with highly variable characteristics. While genome-wide association studies have identified genetic risk factors that implicate underlying pathways, the influence of genetic susceptibility on disease characteristics or treatment response is incompletely understood. We examined the relationships …

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320 Validation of a humanized APOE E4 rat model: preliminary findings

Rebecca J. Solch-Ottaiano, Madison Prats, Nicholas Prus, I-Chen Ivorine Yu et autres

Clinical Utility of an Alzheimer’s Disease Blood Test Among Cognitively Impaired Patients: Results from the Quality Improvement PrecivityAD2 (QUIP II) Clinician Survey Study

Mark Monane, Demetrius M. Maraganore, Kim G. Johnson, David A. Merrill et autres

Objective: The objective of this study was to assess clinical decision-making associated with the use of a multi-analyte blood biomarker (BBM) test among patients presenting with signs or symptoms of mild cognitive impairment or dementia. Methods: The Quality Improvement PrecivityAD2 (QUIP II) …

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Successful Aging Beyond 90 in the US: A Retrospective Cohort Study Leveraging Electronic Health Records and a Computable Phenotype

Jeffrey G. Shaffer, S. Michal Jazwinski, Thomas W. Carton, Stephen Douglas Anton et autres

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Comparison between two divergent diets, Mediterranean and Western, on gut microbiota and cognitive function in young sprague dawley rats

Rebecca J. Solch-Ottaiano, Elizabeth B. Engler-Chiurazzi, C Alex Harper, Savannah Wasson et autres

Clinical studies strongly suggest the importance of diet quality on cognition in youth populations (15-24 years). The Mediterranean diet (MeDi) has been shown to improve cognition in contrast to the commonly consumed Western diet (WD). The gut microbiota may serve as a …

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