Roberta Frigerio

An implantable, intracerebral osmotic pump for convection-enhanced drug delivery in glioblastoma multiforme

Reed Berlet, Azur Azapagic, Daniil P. Aksenov, Jade Bookwalter et autres

Background Glioblastoma multiforme (GBM; WHO Grade 4) is an aggressive brain tumor that invariably recurs after surgical resection, chemoradiation, and adjuvant chemotherapy. Treatment is limited, in part, because the blood-brain barrier (BBB) restricts entry of chemotherapeutic agents to the brain. Introducing drugs …

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Migraine Genetic Susceptibility Does Not Strongly Influence Migraine Characteristics and Outcomes in a Treated, Real-World, Community Cohort

Bruce A. Chase, Roberta Frigerio, Susan Rubin, Irene Semenov et autres

Background/Objectives: Migraine is a common neurological disorder with highly variable characteristics. While genome-wide association studies have identified genetic risk factors that implicate underlying pathways, the influence of genetic susceptibility on disease characteristics or treatment response is incompletely understood. We examined the relationships …

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Lipid trajectories improve risk models for Alzheimer’s disease and mild cognitive impairment

Bruce A. Chase, Roberta Frigerio, Chad J. Yucus, Smita Patel et autres

In this retrospective, case-control study, we tested the hypothesis that blood-lipid concentrations during the decade prior to cognitive symptom onset can inform risk prediction for Alzheimer's disease (AD) and stable mild cognitive impairment (MCI). Clinically well-characterized cases were diagnosed using Diagnostic and …

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An Integrative Migraine Polygenic Risk Score Is Associated with Age at Onset But Not Chronification

Bruce A. Chase, Roberta Frigerio, Susan Rubin, Tiffani Franada et autres

Background/Objective: Genome-wide association studies (GWASs) demonstrate a complex genetic landscape for migraine risk. Migraine polygenic risk scores (PRSs) developed from GWAS data may have utility for predicting disease course. We analyzed the strength of association between an integrative migraine PRS and age …

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Lipid Trajectories Improve Risk Models for Alzheimer’s Disease and Mild Cognitive Impairment

Bruce A. Chase, Roberta Frigerio, Chad J. Yucus, Smita S. Patel et autres

Abstract To assess the relationship between lipids and cognitive dysfunction, we retrospectively analyzed blood-lipid levels in clinically well-characterized individuals with stable mild cognitive impairment (MCI) or Alzheimer’s disease (AD) over the decade prior to first cognitive symptoms. In this case/control cohort study, …

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Characteristics associated with response to subcutaneously administered anti‐CGRP monoclonal antibody medications in a real‐world community cohort of persons living with migraine: A retrospective clinical and genetic study

Bruce A. Chase, Irene Semenov, Susan Rubin, Steven Meyers et autres

OBJECTIVE: To evaluate response to anti-calcitonin gene-related peptide (CGRP) migraine preventives in a real-world community cohort of persons living with migraine and to identify clinical and genetic characteristics associated with efficacious response. BACKGROUND: Erenumab-aooeb, fremanezumab-vrfm, and galcanezumab-gnlm target CGRP or its receptor; …

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Multifactorial assessment of Parkinson’s disease course and outcomes using trajectory modeling in a multiethnic, multisite cohort – extension of the LONG-PD study

Bruce A. Chase, Rejko Krüger, Lukas Pavelka, Sun Ju Chung et autres

Background: The severity, progression, and outcomes of motor and non-motor symptoms in Parkinson's disease (PD) are quite variable. Following PD cohorts holds promise for identifying predictors of disease severity and progression. Methods: = 871) were enrolled at five sites. Enrollment occurred within …

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Mortality risk factors in newly diagnosed diabetic cardiac autonomic neuropathy

Bruce A. Chase, Sylwia Pocica, Roberta Frigerio, Katerina Markopoulou et autres

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Mortality Risk Factors in Patients with Diabetic Autonomic Neuropathy: Insights from a Structured Clinical Documentation Toolkit (P18-1.006)

Alexandru Barboi, Bruce A. Chase, Katerina Markopoulou, Roberta Frigerio et autres

To identify mortality risk factors in patients diagnosed with diabetic autonomic neuropathy (DAN).

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Efficacy of supplemental MCT oil on seizure reduction of adult drug-resistant epilepsy – a single-center open-label pilot study

Emmaline Rasmussen, Vimal Patel, Samuel Tideman, Robert S. Frech et autres

OBJECTIVE: We set out to determine whether adding medium chain triglyceride (MCT) oil as a dietary supplement to standard diet in adult subjects with intractable epilepsy in a U.S. neurology clinical practice was associated with a reduction in number of seizures. We …

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Standardizing Care of Neuro-oncology Patients Using a Customized Electronic Medical Record Toolkit

Ryan Merrell, Kelly Claire Simon, Nina Martinez, Rosa Maria Vazquez et autres

OBJECTIVE: To develop and implement a customized toolkit within the electronic medical record (EMR) to standardize care of patients with brain tumors. PATIENTS AND METHODS: We built a customized structured clinical documentation support toolkit to capture standardized data at office visits. We …

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Variable Effects of PD-Risk Associated SNPs and Variants in Parkinsonism-Associated Genes on Disease Phenotype in a Community-Based Cohort

Katerina Markopoulou, Bruce A. Chase, Ashvini P. Premkumar, Bernadette Schoneburg et autres

Genetic risk factors for Parkinson's disease (PD) risk and progression have been identified from genome-wide association studies (GWAS), as well as studies of familial forms of PD, implicating common variants at more than 90 loci and pathogenic or likely pathogenic variants at …

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