Yee Jie Yeap

APOE4-APP interactions exert early influences on cerebrovascular structure and function: implications for Alzheimer’s disease

Lanboling Guo, Jessica Ruth Gaunt, Calvin Cheah, Albert I. Chen et autres

Background APOE4 and APP are two of the main genetic risk factors for Alzheimer’s disease (AD). Although there have been suggestions that these two factors interact, most of the in vivo evidence for such interactions comes from transgenic mouse models that suffer …

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Role of lipid droplets in neurodegenerative diseases: From pathogenesis to therapeutics

Yubing Kang, Yee Jie Yeap, Jing Yang, Sufang Ma et autres

Neurodegenerative diseases (NDDs) are a series of disorders characterized by the progressive loss of specific neurons, leading to cognitive and locomotor impairment. NDDs affect millions of patients worldwide but lack effective treatments. Dysregulation of lipids, particularly the accumulation of lipid droplets (LDs), …

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Abstract 1338 Visualization of accessible cholesterol in cellular membranes using a GRAM domain-based biosensor

Dylan Hong Zheng Koh, Tomoki Naito, Minyoung Na, Yee Jie Yeap et autres

Cholesterol plays a significant role in maintaining membrane integrity and cell signaling. Dysregulation of the distribution of cellular cholesterol is associated with numerous diseases, including cardiovascular and neurological diseases. While regulated transport of a specific pool of cholesterol, known as “accessible cholesterol” …

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Unravelling the role of BACE2 in Alzheimer's disease using a cerebral organoid model

Yee Jie Yeap

BACE2 is a protease intricately involved in the amyloid processing pathway, crucial to the pathogenesis of Alzheimer’s Disease (AD), yet its role remains contentious due to conflicting evidence suggesting it may be neuroprotective or disease-driving. This thesis hypothesizes that BACE2 deficiency contributes …

Visualization of accessible cholesterol using a GRAM domain-based biosensor

Dylan Hong Zheng Koh, Tomoki Naito, Minyoung Na, Yee Jie Yeap et autres

Cholesterol is important for membrane integrity and cell signaling, and dysregulation of the distribution of cellular cholesterol is associated with numerous diseases, including neurodegenerative disorders. While regulated transport of a specific pool of cholesterol, known as "accessible cholesterol", contributes to the maintenance …

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Dose imbalance of DYRK1A kinase causes systemic progeroid status in Down syndrome by increasing the un-repaired DNA damage and reducing LaminB1 levels

Aoife Murray, Gillian Gough, Ana Cindrić, Frano Vučković et autres

BACKGROUND: People with Down syndrome (DS) show clinical signs of accelerated ageing. Causative mechanisms remain unknown and hypotheses range from the (essentially untreatable) amplified-chromosomal-instability explanation, to potential actions of individual supernumerary chromosome-21 genes. The latter explanation could open a route to therapeutic …

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From 2D to 3D: Development of Monolayer Dopaminergic Neuronal and Midbrain Organoid Cultures for Parkinson’s Disease Modeling and Regenerative Therapy

Yee Jie Yeap, Teddy J. W. Tng, Mok Jung Lee, Micaela J. Goh et autres

Parkinson's Disease (PD) is a prevalent neurodegenerative disorder that is characterized pathologically by the loss of A9-specific dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc) of the midbrain. Despite intensive research, the etiology of PD is currently unresolved, and the …

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BACE2: A Promising Neuroprotective Candidate for Alzheimer’s Disease

Yee Jie Yeap, Nagaendran Kandiah, Dean Nižetić, Kah‐Leong Lim

Alzheimer's disease (AD) is the most common cause of dementia that affects millions of predominantly elderly individuals worldwide. Despite intensive research over several decades, controversies still surround the etiology of AD and the disease remains incurable. Meanwhile, new molecular players of the …

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Correction: Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene dose-sensitive AD suppressor in human brain

Ivan Alić, Pollyanna Agnes Goh, Aoife Murray, Erik Portelius et autres

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Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene dose-sensitive AD suppressor in human brain

Ivan Alić, Pollyanna Agnes Goh, Aoife Murray, Erik Portelius et autres

A population of more than six million people worldwide at high risk of Alzheimer's disease (AD) are those with Down Syndrome (DS, caused by trisomy 21 (T21)), 70% of whom develop dementia during lifetime, caused by an extra copy of β-amyloid-(Aβ)-precursor-protein gene. …

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“Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene-dose-sensitive AD-suppressor in human brain”

Ivan Alić, Pollyanna Agnes Goh, Aoife Murray, Erik Portelius et autres

Abstract A population of >6 million people worldwide at high risk of Alzheimer’s disease (AD) are those with Down Syndrome (DS, caused by trisomy 21 (T21)), 70% of whom develop dementia during lifetime, caused by an extra copy of β-amyloid-(Aβ)-precursor-protein gene. We …

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Modeling Down syndrome in cells: From stem cells to organoids

Gillian Gough, Niamh Louise O’Brien, Ivan Alić, Pollyanna Agnes Goh et autres

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