Elettra Mancuso

Alpha 2-HS glycoprotein increases glucagon synthesis and secretion in cells, mice, and humans

Elettra Mancuso, Carolina Averta, Mariangela Rubino, Rita Citraro et autres

Alpha-2-HS-glycoprotein (Fet-A), a hepatocyte-derived glycoprotein, is known to influence insulin resistance and inflammation, but its impact on pancreatic alpha cell function and glucagon secretion is not well understood. To unravel the molecular mechanisms underlying Fet-A action on glucagon synthesis, we used pancreatic …

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Sex differences in the association of uric acid to HDL-cholesterol ratio (UHR) with subclinical cardiovascular damage

Mariangela Rubino, Angela Palummo, Mattia Massimino, Carolina Averta et autres

Abstract Background Cardiovascular diseases remain the leading cause of global mortality, with risk increasing significantly in women post-menopause. Identifying accessible biomarkers for subclinical risk stratification is a clinical priority. The uric acid to HDL-cholesterol ratio (UHR) has emerged as a composite marker …

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Palmitoylethanolamide in Human and Animal Obesity

Clara Naccari, Elettra Mancuso, Eugenio Donato Di Paola, Giovambattista De Sarro

Background: With the increase in the middle-aged population and sedentary lifestyle, a high incidence of obesity has been observed in humans and in animals. Obesity is consequent or correlated to multiple diseases, such as metabolic-dysfunction-associated fatty liver disease (MASLD), diabetes, dyslipidemia, etc. …

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Circulating uric acid is independently associated with MASLD prevalence and non-invasive advanced fibrosis risk stratification in a Caucasian T2DM cohort

Mattia Massimino, Angela Palummo, Mariangela Rubino, Carolina Averta et autres

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a primary cause of chronic liver disease, affecting over half of individuals with Type 2 Diabetes Mellitus (T2DM). Although uric acid (UA) is linked to metabolic risk factors, its independent association with MASLD presence and …

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Modulation of mitochondrial DNA copy number: therapeutic potential of phytochemicals and plant extracts—a comprehensive review

Maria Rosaria Perri, Annamaria Cerantonio, Maria Grazia Cipriani, Ida Manna et autres

Mitochondrial DNA copy number (mtDNA-CN) is a critical marker of mitochondrial health and plays a key role in cellular bioenergetics. Alterations in mtDNA-CN have been associated with aging, metabolic disorders and neurodegenerative diseases. Recent studies have revealed that various plant-derived extracts, as …

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Nerve Growth Factor in Diabetes Mellitus: Pathophysiological Mechanisms, Biomarkers and Therapeutic Opportunities

Mattia Massimino, Mariangela Rubino, Maria Resilde Natale, Luca Salerno et autres

Background: Type 2 diabetes mellitus represents a global health challenge, with chronic hyperglycemia leading to a spectrum of microvascular and macrovascular complications. This narrative review provides a comprehensive and integrated analysis of the nerve growth factor (NGF) axis as a key, yet …

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Association between gut microbiota composition and physical functioning in patients with knee osteoarthritis: a machine learning study

Alessandro de Sire, Elettra Mancuso, Nicola Marotta, Mattia Massimino et autres

Gut dysbiosis and systemic inflammation are increasingly recognized in the pathogenesis of knee osteoarthritis (OA). While altered gut microbiota profiles have been reported, the link between specific microbial taxa and physical functioning in OA patients remains understudied. This study investigated the association …

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Cathepsin K: a novel association with glucose intolerance, insulin resistance, and subclinical atherosclerosis in T2DM

Carolina Averta, Mariangela Rubino, Elettra Mancuso, Mattia Massimino et autres

BACKGROUND: Cathepsin K (CatK) contributes to vessel collagene remodelling and high CatK concentrations have been found in atherosclerotic lesions. CatK ablation in a murine model determined an amelioration of diabetes-induced hyperglycemia and cardiovascular structural/functional abnormalities. To date, it is unknown whether glucose …

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Serum uric acid to HDL-Chol ratio (UHR) is associated with insulin resistance/sensitivity in individuals without diabetes

Mariangela Rubino, Mattia Massimino, Elettra Mancuso, Carolina Averta et autres

BACKGROUND: The uric acid-to-HDL cholesterol ratio (UHR) is a promising non-insulin-based marker for metabolic risk, associated with type 2 diabetes, hypertension, hepatic steatosis, and cardiovascular disease. However, its utility in individuals with altered glucose tolerance remains unclear. METHODS: We investigated the relationship …

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An Ascaris lumbricoides infection diagnosed by colonoscopy: A case report and a brief literature review

Simona Gigliotti, Elettra Mancuso, Marta Pantanella, Michele Manno et autres

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Glucagon kinetics assessed by mathematical modelling during oral glucose administration in people spanning from normal glucose tolerance to type 2 diabetes

Francesco Andreozzi, Elettra Mancuso, Mariangela Rubino, Benedetta Salvatori et autres

Background/Objectives Glucagon is important in the maintenance of glucose homeostasis, with also effects on lipids. In this study, we aimed to apply a recently developed model of glucagon kinetics to determine the sensitivity of glucagon variations (especially, glucagon inhibition) to insulin levels …

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One‐hour post‐load glucose levels are associated with hepatic steatosis assessed by transient elastography

Francesco Andreozzi, Elettra Mancuso, Elisa Mazza, Gaia Chiara Mannino et autres

AIM: To examine the association between 1-hour plasma glucose (PG) concentration and markers of non-alcoholic fatty liver disease (NAFLD) assessed by transient elastography (TE). METHODS: We performed TE in 107 metabolically well-characterized non-diabetic White individuals. Controlled attenuation parameter (CAP) was used to …

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