Mattia Massimino

Alpha 2-HS glycoprotein increases glucagon synthesis and secretion in cells, mice, and humans

Elettra Mancuso, Carolina Averta, Mariangela Rubino, Rita Citraro et autres

Alpha-2-HS-glycoprotein (Fet-A), a hepatocyte-derived glycoprotein, is known to influence insulin resistance and inflammation, but its impact on pancreatic alpha cell function and glucagon secretion is not well understood. To unravel the molecular mechanisms underlying Fet-A action on glucagon synthesis, we used pancreatic …

it (code pays fourni par la source)

Sex differences in the association of uric acid to HDL-cholesterol ratio (UHR) with subclinical cardiovascular damage

Mariangela Rubino, Angela Palummo, Mattia Massimino, Carolina Averta et autres

Abstract Background Cardiovascular diseases remain the leading cause of global mortality, with risk increasing significantly in women post-menopause. Identifying accessible biomarkers for subclinical risk stratification is a clinical priority. The uric acid to HDL-cholesterol ratio (UHR) has emerged as a composite marker …

it (code pays fourni par la source)

Circulating uric acid is independently associated with MASLD prevalence and non-invasive advanced fibrosis risk stratification in a Caucasian T2DM cohort

Mattia Massimino, Angela Palummo, Mariangela Rubino, Carolina Averta et autres

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a primary cause of chronic liver disease, affecting over half of individuals with Type 2 Diabetes Mellitus (T2DM). Although uric acid (UA) is linked to metabolic risk factors, its independent association with MASLD presence and …

it (code pays fourni par la source)

Nerve Growth Factor in Diabetes Mellitus: Pathophysiological Mechanisms, Biomarkers and Therapeutic Opportunities

Mattia Massimino, Mariangela Rubino, Maria Resilde Natale, Luca Salerno et autres

Background: Type 2 diabetes mellitus represents a global health challenge, with chronic hyperglycemia leading to a spectrum of microvascular and macrovascular complications. This narrative review provides a comprehensive and integrated analysis of the nerve growth factor (NGF) axis as a key, yet …

it (code pays fourni par la source)

Association between gut microbiota composition and physical functioning in patients with knee osteoarthritis: a machine learning study

Alessandro de Sire, Elettra Mancuso, Nicola Marotta, Mattia Massimino et autres

Gut dysbiosis and systemic inflammation are increasingly recognized in the pathogenesis of knee osteoarthritis (OA). While altered gut microbiota profiles have been reported, the link between specific microbial taxa and physical functioning in OA patients remains understudied. This study investigated the association …

it (code pays fourni par la source)

Cathepsin K: a novel association with glucose intolerance, insulin resistance, and subclinical atherosclerosis in T2DM

Carolina Averta, Mariangela Rubino, Elettra Mancuso, Mattia Massimino et autres

BACKGROUND: Cathepsin K (CatK) contributes to vessel collagene remodelling and high CatK concentrations have been found in atherosclerotic lesions. CatK ablation in a murine model determined an amelioration of diabetes-induced hyperglycemia and cardiovascular structural/functional abnormalities. To date, it is unknown whether glucose …

it (code pays fourni par la source)

Serum uric acid to HDL-Chol ratio (UHR) is associated with insulin resistance/sensitivity in individuals without diabetes

Mariangela Rubino, Mattia Massimino, Elettra Mancuso, Carolina Averta et autres

BACKGROUND: The uric acid-to-HDL cholesterol ratio (UHR) is a promising non-insulin-based marker for metabolic risk, associated with type 2 diabetes, hypertension, hepatic steatosis, and cardiovascular disease. However, its utility in individuals with altered glucose tolerance remains unclear. METHODS: We investigated the relationship …

it (code pays fourni par la source)

Ruolo del microbiota intestinale nel diabete mellito di tipo 2: nuove prospettive terapeutiche

Federica Catalano, Mattia Massimino, Marta Letizia Hribal

Recent evidence suggests that intestinal microbiota may have a role in pathogenesis of type 2 diabetes (T2DM), throughout the modulation of glucose homeostasis, insulin sensitivity, and chronic inflammation. Despite some contradictory results, it has been possible to identify several features associated with …

Evaluation of the intestinal microbiota and correlation with functioning in patients suffering from knee osteoarthritis: a cross-sectional study

Roberta Zito, Nicola Marotta, Isabella Bartalotta, Maria Sgro et autres

Purpose: The aim of this study was to evaluate the composition and metabolic activity of the gut microbiota (GM) in a cohort of patients suffering from knee osteoarthritis (OA) and its impact on their functional status. Methods: We recruited patients with a …

it (code pays fourni par la source)

Compromised cardiac autonomic function in non-diabetic subjects with 1 h post-load hyperglycemia: a cross-sectional study

Giuseppe Monea, Raffaele Jiritano, Luca Salerno, Mariangela Rubino et autres

BACKGROUND: A compromised cardiac autonomic function has been found in subjects with insulin resistance related disorders such as obesity, impaired glucose tolerance (IGT) and type 2 diabetes and confers an increased risk of adverse cardiovascular outcomes. Growing evidence indicate that 1 h …

it (code pays fourni par la source)

Sex-specific differences in myocardial glucose metabolic rate in non-diabetic, pre-diabetic and type 2 diabetic subjects

Elena Succurro, Patrizia Vizza, Francesco Cicone, Velia Cassano et autres

BACKGROUND: Evidence has shown that women with type 2 diabetes (T2DM) have a higher excess risk for cardiovascular disease (CVD) than men with T2DM. Subjects with either T2DM or prediabetes exhibit myocardial insulin resistance, but it is still unsettled whether sex-related differences …

it (code pays fourni par la source)

Asymmetric dimethylarginine (ADMA) is associated with reduced myocardial mechano-energetic efficiency in hypertensive subjects

CHIARA MARIA ASSUNTA CEFALO, Alessia Riccio, Teresa Vanessa Fiorentino, Mattia Massimino et autres

it (code pays fourni par la source)