Valentina Laverde

Self-antigen disrupts cDC1 mediated antitumor responses

Victoria Schuster, Kasidy Brown, Valentina Laverde, Naomi Berkowitz et autres

ABSTRACT Conventional dendritic cells navigate complex tissues and sample peripheral antigens, balancing immune suppression and activation to achieve tissue homeostasis. However, it remains unclear how an individual dendritic cells reconciles co-incident signals from immunological opposing antigens within the tissue or tumor microenvironment, …

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Single-cell RNA-seq data of wild type and fli1b mutant zebrafish embryos

Luiza N. Loges, Ricardo A. DeMoya, Valentina Laverde, Saulius Sumanas

Fli1b is an ETS transcription factor, which has been previously implicated in zebrafish vascular and hematopoietic development. Here we present single cell RNA sequencing data from wild-type and maternal zygotic fli1b mutant zebrafish embryos at 24 hours post fertilization. Single-cell suspensions were …

Contextual control of CD8 + T cell priming by dendritic cell subsets in tumor and inflammatory microenvironments

Victoria Schuster, Naomi Berkowitz, Kasidy Brown, Catherine Rousculp et autres

SUMMARY Conventional dendritic cells orchestrate adaptive immunity by trafficking peripheral antigens to draining lymph nodes and presenting peptide–MHC complexes to prime naïve T cells. Migratory and lymph node resident conventional dendritic cell subsets occupy distinct anatomical niches and have been shown to …

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The zebrafish ETS transcription factor Fli1b functions upstream of Scl/Tal1 during embryonic hematopoiesis

Valentina Laverde, Luiza N. Loges, Saulius Sumanas

During embryonic development, vascular endothelial and hematopoietic cells are thought to originate from a common precursor, the hemangioblast. The evolutionarily conserved ETS transcription factor FLI1 has been previously implicated in hemangioblast formation and hematopoietic and vascular development. However, its role in regulating …

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SH2 domain protein E and ABL signaling regulate blood vessel size

Jennifer A. Schumacher, Zoë A. Wright, Diandra Rufin Florat, Surendra Kumar Anand et autres

Blood vessels in different vascular beds vary in size, which is essential for their function and fluid flow along the vascular network. Molecular mechanisms involved in the formation of a vascular lumen of appropriate size, or tubulogenesis, are still only partially understood. …

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Abstract C043: SHIP-1: Therapeutic target to reduce health disparities in African Americans with pancreatic cancer

Krystal Villalobos-Ayala, Valentina Laverde, Jennifer B. Permuth, William Garrow Kerr et autres

Abstract Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers and African Americans (AA) have higher mortality rates compared to European Americans (EA) due to heighten inflammation which is known to be regulated by Src-homology inositol phosphatase-1 (SHIP-1). SHIP-1 is a …

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Apigenin Targets MicroRNA-155, Enhances SHIP-1 Expression, and Augments Anti-Tumor Responses in Pancreatic Cancer

Kazim M. Husain, Krystal Villalobos-Ayala, Valentina Laverde, Oscar Adrian Vazquez et autres

Pancreatic cancer (PC) is a deadly disease with a grim prognosis. Pancreatic tumor derived factors (TDF) contribute to the induction of an immunosuppressive tumor microenvironment (TME) that impedes the effectiveness of immunotherapy. PC-induced microRNA-155 (miRNA-155) represses expression of Src homology 2 (SH2) …

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