Glen Traver Hart

Abstract 6866: Mapping cancer-relevant genetic interactions with functional module prediction and in4mer enCas12a platform.

Chenchu Lin, Veronica Gheorghe, Juihsuan Rosalind Chou, Sabriyeh Alibai et autres

Abstract Genetic interaction (GI), particularly synthetic lethality, is essential to functional genomics and cancer therapy. In yeast, systematic GI mapping has produced a near-complete network covering ∼90% of genes, establishing core principles of GI network architecture and defining major functional modules. However, …

us (code pays fourni par la source)

Abstract 6894: Predict, perturb, and process: A systems biology pipeline for identifying synthetic lethality.

Juihsuan Chou, Chenchu Lin, Iulia Veronica Gheorghe, Sabriyeh Alibai et autres

Abstract The synthetic lethality principle holds great promise for cancer therapy, but identifying synthetic lethals presents enormous challenges. Synthetic lethality, where loss of two genes causes cell death, but loss of either gene alone does not, is difficult to assay because combinatorial …

us (code pays fourni par la source)

C17orf53 defines a novel pathway involved in inter-strand crosslink repair

Chao Wang, Zhen Chen, Dan Su, Mengfan Tang et autres

Summary ATR kinase is a master regulator of genome maintenance and participates in DNA replication and various DNA repair pathways. In a genome-wide screening for ATR-dependent fitness genes, we identified a previously uncharacterized gene, C17orf53, whose loss led to hypersensitivity to ATR …

us (code pays fourni par la source)

Genome-wide CRISPR screens reveal synthetic lethality of RNASEH2 deficiency and ATR inhibition

Chao Wang, Gang Wang, Xu Feng, Peter D.A. Shepherd et autres

us (code pays fourni par la source)

Computational and experimental methods in functional genomics : the good, the bad, and the ugly of systems biology

Glen Traver Hart

First, I would like to thank the many members of the Marcotte, Ellington, and Iyer labs, past and present, for showing me how to be both a