Maria Patrani

sCD126 as An Independent Prognostic Biomarker in Critical COVID-19

Giorgos Marinakis, Eleni Karakike, Panagiotis Koufargyris, Maria Patrani et autres

INTRODUCTION: Biomarkers to predict response of critical COVID-19 to tocilizumab (TCZ) are under investigation. Serum levels of interleukin (IL)-6 and IL-6 soluble receptors were studied in a cohort of patients all receiving treatment with TCZ. METHODS: In this prospective clinical study, IL-6, …

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Precision Immunotherapy to Improve Sepsis Outcomes

Evangelos J. Giamarellos‐Bourboulis, Antigone Kotsaki, Ioanna Kotsamidi, Vasiliki Koutsoukou et autres

Importance: Sepsis is heterogeneous, and the optimal strategy for tailoring immunotherapy is uncertain. Objective: To investigate whether precision immunotherapy guided by the presence of macrophage activation-like syndrome or sepsis-induced immunoparalysis improves organ dysfunction by day 9. Design, Setting, and Participants: A randomized, …

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Evaluation of the Trauma and Injury Severity Score (TRISS) Performance in Intensive Care Trauma Patients: A Systematic Review and Meta-Analysis

Georgios Velonas, Dimitrios Mantas, Georgios Kassianidis, Vasiliki Poulianidou et autres

The Trauma and Injury Severity Score (TRISS) is a widely implemented tool for predicting outcomes in trauma patients. However, the application of the TRISS in intensive care units (ICUs) is limited, and data from international sources are scarce, as it requires adaptation …

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Effect of intravenous clarithromycin in patients with sepsis, respiratory and multiple organ dysfunction syndrome: a randomized clinical trial

Eleni Karakike, Brendon P. Scicluna, Maria Roumpoutsou, Ioannis Mitrou et autres

BACKGROUND: Clarithromycin may act as immune-regulating treatment in sepsis and acute respiratory dysfunction syndrome. However, clinical evidence remains inconclusive. We aimed to evaluate whether clarithromycin improves 28-day mortality among patients with sepsis, respiratory and multiple organ dysfunction syndrome. METHODS: We conducted a …

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Community-acquired Klebsiella spp Meningitis/Invasive Infection in Filipino-descent Patients Living in Greece: A Case Series

Giorgos Marinakis, Georgios Kassianidis, Eleni Kafkoula, Christina Stamatopoulou et autres

invasive syndrome) occurring usually in diabetic, alcoholic, elderly or cancer patients, in Taiwan and other South-East Asian countries. In Western countries, these infections are very rare in natives and usually occur in patients of Asian origin. We report three cases of Filipino-origin …

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Non-interventional monitoring of expiratory flow limitation during experimental mechanical ventilation

Giorgos Marinakis, Michael D. Paraschos, Maria Patrani, Theodoros Tsoutsouras et autres

Background Expiratory flow limitation (EFL) is common among patients in the intensive care unit under mechanical ventilation (MV) and may have significant clinical consequences. In the present study, we examine the possibility of non-interventional detection of EFL during experimental MV. Methods Eight …

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Late Breaking Abstract - Non-interventional monitoring of expiratory flow limitation during experimental mechanical ventilation

Giorgos Marinakis, Michael D. Paraschos, Maria Patrani, Theodoros Tsoutsouras et autres

Background: Εxpiratory flow limitation (EFL) is common under mechanical ventilation (MV) and may have significant clinical consequences. Aim: Our main objective is to examine the possibility of non-interventional detection of EFL during experimental MV. Methods: In the present study, eight artificially ventilated …

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Past history of stage I/II solid tumor malignancy impacts considerably on sepsis mortality: a propensity score matching analysis from the hellenic sepsis study group

George Dimοpoulos, Nikoletta Rovina, Maria Patrani, Eleni Antoniadou et autres

BACKGROUND: Whether past history of solid stage I/II inactive cancer has an impact on 28-day mortality of sepsis remains unclear. We aimed to determine the impact of history of stage I or II solid tumor malignancy in complete remission the last 3 …

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Soluble urokinase plasminogen activator receptor informs on the progression course after multiple injuries

Maria Patrani, Thomas Tsaganos, Katerina E. Kotzampassi, Michael D. Paraschos et autres

PURPOSE: The purpose of this study is to study the use of soluble urokinase plasminogen activator receptor (suPAR) for the prognosis of multiple organ dysfunction (MOF) after multiple traumas. METHODS: Serum suPAR was measured within the first 24 h after multiple injuries …

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Defective cytokine production early after multiple traumas: Modulation in severe sepsis

Michael D. Paraschos, Maria Patrani, Aikaterini C. Pistiki, Chrisostomos Katsenos et autres

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Early changes of the kinetics of monocyte trem-1 reflect final outcome in human sepsis

Androniki Marioli, Marina Koupetori, Maria Raftogiannis, Maria Patrani et autres

BACKGROUND: TREM-1 (triggering receptor expressed on myeloid cells), a receptor expressed on neutrophils and monocytes, is upregulated in sepsis and seems to tune the inflammatory response. We explored the expression of TREM-1 at the gene level and on cell membranes of monocytes …

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Early Administration of Hydrocortisone Replacement After the Advent of Septic Shock

Chrisostomos Katsenos, Anastasia N. Antonopoulou, Efterpi Apostolidou, Aikaterini Ioakeimidou et autres

OBJECTIVES: To investigate the impact of early initiation of hydrocortisone therapy on the clinical course of septic shock and on cytokine release. DESIGN: Prospective study in patients with septic shock treated with low doses of hydrocortisone. SETTING: ICUs and general wards. PATIENTS: …

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