Yury E Khudyakov

A high prevalence of hepatitis B virus strains sharing a single S gene variant in Pakistan

Hong Thi Cam Thai, Iqra Almas, Guo-liang Xia, Yulin Lin et autres

HBV infection is a significant public health problem in Pakistan. However, little is known about HBV genetic heterogeneity in the country. Here, we study inter- and intra-host heterogeneity of the HBV S gene. HBV S gene was sequenced using Sanger and Next-Generation …

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Assessment of PHRED Score Characteristics in Illumina MiSeq Amplicon Sequencing

Seth Sims, Yury E Khudyakov, Alexander Zelikovsky

PHRED scores are confidence values associated with each basecall generated by sequencers. The score is defined as a monotonic function of the probability that the basecall is incorrect. The calibration of PHRED scores has previously been examined by evaluating errors made in …

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Special Section: 12th International Computational Advances in Bio and Medical Sciences (ICCABS 2023)

Mukul Subodh Bansal, Wei Chen, Yury E Khudyakov, Ion Măndoiu et autres

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Strategies and Opportunities to Improve Community Health through Advanced Molecular Detection and Genomic Surveillance of Infectious Diseases

Jazmyn T. Moore, R. Sanon, Yury E Khudyakov, Nathelia Barnes

Advanced molecular detection (AMD) refers to the integration of next-generation sequencing, epidemiologic, and bioinformatics data to drive public health actions. As new AMD technologies emerge, it is critical to ensure those methods are used in communities that are most affected by disease-induced …

Assessment of PHRED Score Characteristics inIllumina MiSeq Amplicon Sequencing

Seth Sims, Yury E Khudyakov, Alex Zelikovsky

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A high prevalence of hepatitis B virus strains sharing a single S gene variant in Pakistan

Hong Thi Cam Thai, Iqra Almas, Guo-liang Xia, Y.C. Lin et autres

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Widespread hepatitis C virus transmission network among people who inject drugs in Kenya

Matthew Jiro Akiyama, Yury E Khudyakov, Sumathi Ramachandran, Lindsey R. Riback et autres

OBJECTIVES: Hepatitis C virus (HCV) disproportionately affects people who inject drugs (PWID) worldwide. Despite carrying a high HCV burden, little is known about transmission dynamics in low- and middle-income countries. METHODS: We recruited PWID from Nairobi and coastal cities and towns of …

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Country-Wide Hepatitis C Virus Transmission Networks Among People Who Inject Drugs in Kenya

Matthew Jiro Akiyama, Yury E Khudyakov, Sumathi Ramachandran, Lindsey R. Riback et autres

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Polyvalent immunization elicits a synergistic broadly neutralizing immune response to hypervariable region 1 variants of hepatitis C virus

Alexander I. Mosa, David S. Campo, Yury E Khudyakov, Mounir G. AbouHaidar et autres

A hepatitis C virus (HCV) vaccine is urgently needed. Vaccine development has been hindered by HCV’s genetic diversity, particularly within the immunodominant hypervariable region 1 (HVR1). Here, we developed a strategy to elicit broadly neutralizing antibodies to HVR1, which had previously been …

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Characterization of recent HCV infections and re-infections among the high-risk population from Georgia using global hepatitis outbreak and surveillance technology

Adam Kotorashvili, Amiran Gamkrelidze, Tamar Gabunia, Nato Kotaria et autres

A Novel Information-Theory-Based Genetic Distance That Approximates Phenotypic Differences

David S. Campo, Alexander I. Mosa, Yury E Khudyakov

Application of genetic distances to measure phenotypic relatedness is a challenging task, reflecting the complex relationship between genotype and phenotype. Accurate assessment of proximity among sequences with different phenotypic traits depends on how strongly the chosen distance is associated with structural and …

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Contributors

Mark J. Abzug, Priyamvada Acharya, Anna M. Acosta, S. Sohail Ahmed et autres

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